DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and Myo1e

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_775124.1	Gene:	Myo1e / 25484	RGDID:	3144	Length:	1107	Species:	Rattus norvegicus

Alignment Length:	994	Identity:	348/994 - (35%)
Similarity:	542/994 - (54%)	Gaps:	153/994 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 REAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGREL 69
            :.:||.|.|||.:::....::||:||:.:..|:||||.|.:|:||::||..:|.:.|..|:|...
  Rat    17 KHSGVDDMVLLSKITESSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQ 81

  Fly    70 FENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKN 134
            :||.||::|:|||.||.:...:::.|::||||||||||.|:|.||.|::.|:.  |..:::.||:
  Rat    82 YENPPHIYALADSMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYVSRVSG--GGPKVQHVKD 144

  Fly   135 VLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNF 199
            :::|||.:||.||||||.||:||||||||.:|:|....:|.||.|:|:||||||||.:.||||:|
  Rat   145 IILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSF 209

  Fly   200 HSFYQLLRGANDNELRQYELQKETGKYHYLN-QGS--MDILTEKSDYKGTCNAFKTLGFSTDEVQ 261
            |.||||:.||:..:.:...: .....|:||: .||  :|.:.:|.|::.|.:|...:|..::|..
  Rat   210 HIFYQLIEGASPEQKQSLGI-TSMDYYYYLSLSGSYKVDDIDDKRDFQETLHAMNVIGIFSEEQT 273

  Fly   262 TIWRTIAAVLHLGNVEFQTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVI-AAGGNVMQK 325
            .:.:.:|.:|||||:.|:.:.:...:.:::.|...|.||.:.:..|...||.|.: :..|...:.
  Rat   274 LVLQIVAGILHLGNINFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSES 338

  Fly   326 DH---NATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDS 387
            .|   |..||.|.:||||||::.|:|.:::..||:|:    .|....:|  ||||||||||||..
  Rat   339 IHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAM----EKDHEEYN--IGVLDIYGFEIFQK 397

  Fly   388 NSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQP--HKGIIAI 450
            |.|||||||:.||||||:||||.||.|||||.:|||.||.||||||||:|||:|..  ..||::|
  Rat   398 NGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIESKVNPPGIMSI 462

  Fly   451 MDEACL---SVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNIN 512
            :|:.|.   :||:..|.|||..:...:..|.|:.|           ..:.|.|.||||.|.|:::
  Rat   463 LDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNS-----------WNQGFIIHHYAGKVSYDMD 516

  Fly   513 GFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKK 577
            ||.|:|:|.|:.|...|:.:|:...:..::||..|..||  .||.|||:..::...|||.||:|.
  Rat   517 GFCERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKK--GRPTTAGSKIKKQANDLVSTLMKC 579

  Fly   578 EPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTW 642
            .|.|:||||||:.|....::|.||:|||.||||.||:||||||:.:|:.:.|||.||.::::.||
  Rat   580 TPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKATW 644

  Fly   643 PNFRAGSDRDGVRVLIEEKKFAQD-VKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRG 706
            |.:| |.::.||..|::......| .:.|.:|:||::|.:||.||..|.........::||..|.
  Rat   645 PVWR-GDEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKTWRK 708

  Fly   707 WIVRRNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKL 771
            ::.|:.:.:|:                   |.|:.|...|:.|
  Rat   709 FVARKKYVQMR-------------------EDASDLLLNKKER---------------------- 732

  Fly   772 HRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQENSGYEAYN 836
                   |.|.|                               .|.::|||: ..:|:...:.:.
  Rat   733 -------RRNSI-------------------------------NRNFIGDYI-GMEEHPELQQFV 758

  Fly   837 GSIKNIRNHPADGETFQQVLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKD------- 894
            |..:.|.             |:..|.|::...|...|..:::...::.:.  :.|.|.
  Rat   759 GKREKID-------------FADIVTKYDRRFKGVKRDLLLTPKCLYLIG--REKVKQGPDKGLV 808

  Fly   895 ---MKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFSLESEYTPLKEDRI-GEVVGIVCKKYH 955
               :||.|::..:.|:|:|..:|.:.:.|           |.||..|.|... .|.:.::.|:|.
  Rat   809 KEVLKRKIEVERILSVSLSTMQDDIFILH-----------EQEYDSLLESVFKTEFLSLLTKRYE 862

  Fly   956 DLTGTELRVNVTTNISCRL 974
            :.|..:|.:..:..:..:|
  Rat   863 EKTQKQLPLKFSNTLELKL 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	301/696 (43%)
		MYSc_Myo1	21..677	CDD:276829	289/668 (43%)
		Myosin_TH1	801..983	CDD:283635	33/185 (18%)
Myo1e	NP_775124.1	MYSc	14..692	CDD:214580	301/697 (43%)
		MYSc_Myo1	33..679	CDD:276829	289/668 (43%)
		Actin-binding. /evidence=ECO:0000255	581..591		7/9 (78%)
		Myosin_TH1	719..899	CDD:283635	41/269 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	920..1052
		SH3_MyoIe_If_like	1055..1106	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820