DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and Myo1g

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	XP_006514763.1	Gene:	Myo1g / 246177	MGIID:	1927091	Length:	1039	Species:	Mus musculus

Alignment Length:	987	Identity:	489/987 - (49%)
Similarity:	663/987 - (67%)	Gaps:	34/987 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENAPHLFAIADSAYRVLKQRQQDT 94
            :|:.|.||||||||.||:|||:::.:||||.|.||:||||:|..|||:|:|::||:.:|:|.:||
Mouse    53 KFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIAKYQGRELYERPPHLYAVANAAYKAMKRRSRDT 117

  Fly    95 CILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVLIQSNAILETFGNAKTNRNDNSSR 159
            ||:||||||||||||||.||:|||||||...:.|:|||||||::|..:||.||||:||||.||||
Mouse   118 CIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKNVLLKSTCVLEAFGNARTNRNHNSSR 182

  Fly   160 FGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHSFYQLLRGANDNELRQYELQKETG 224
            |||||||.||:|.|||||.|.:||||||||::|..||||||:|||||||:.|.||:...|::...
Mouse   183 FGKYMDINFDFKGDPVGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSEDQELQGLHLERNPA 247

  Fly   225 KYHYLNQG---------SMDILTEKSDYKGTCNAFKTLGFSTDEVQTIWRTIAAVLHLGNVEFQT 280
            .|::..||         ::|  :::..::|...|.:.:|||.|||::|.|.:||:|||||:||..
Mouse   248 VYNFTRQGAGLNMGVHNALD--SDEKSHQGVMEAMRIIGFSPDEVESIHRILAAILHLGNIEFVE 310

  Fly   281 IEDE------LVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGG-NVMQKDHNATQAEYGKDA 338
            .|:.      |.::::..:...|||.......:...|..|.:|:|| .|::|.|...:|.|.:||
Mouse   311 TEENGPQKGGLEVADEALVGYVAKLTATPRDLVLRTLLARTVASGGREVIEKSHTVAEASYARDA 375

  Fly   339 LAKAIYDRLFTWIISRINRAILFRGSKTQA-RFNSVIGVLDIYGFEIFDSNSFEQFCINYCNEKL 402
            .|||:|.|||.|::::||..:..|....:. ..::|||||||||||:|..|||||||||||||||
Mouse   376 CAKAMYQRLFEWVVNKINSIMEPRNRDPRCDGKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKL 440

  Fly   403 QQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDEACLSVGKVTDDTLL 467
            |||||:|:||||||||:||||.|..||||||..|.:||||||:||:|::||||.:.|.:||...|
Mouse   441 QQLFIQLILKQEQEEYEREGIAWQTIEYFNNATIVELVEQPHRGILAVLDEACSTAGPITDRIFL 505

  Fly   468 GAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFIEKNKDTLYQDFKRLLHN 532
            ..:|.:...||||:||||.||||.::...||:|.||||||.|::.|||:||:|:|:|||||||:|
Mouse   506 QTLDTHHRHHPHYSSRQLCPTDKTMEFGRDFQIKHYAGDVTYSVEGFIDKNRDSLFQDFKRLLYN 570

  Fly   533 SKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFD 597
            |.|..|..|||:|.|||.:.|||||||||||:.||..||..|..||||||||||||:.|.:...|
Mouse   571 SVDPTLRAMWPDGQQDITEVTKRPLTAGTLFKNSMVALVENLASKEPFYVRCIKPNEDKVAGRLD 635

  Fly   598 EERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAGSDRDGVRVLIEEKK 662
            |....|||.|||||||:|||||||..||.|.:|||||||..:|||||...|||||.|..|:|:..
Mouse   636 EAHCRHQVEYLGLLENVRVRRAGFASRQPYPRFLLRYKMTCEYTWPNHLLGSDRDAVSALLEQHG 700

  Fly   663 FAQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMKAAITIVRAYK 727
            ...||.:||:|:||||||||..||..|..:||.||.||||..||.:.|.:.::::|..||:|.::
Mouse   701 LQGDVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQKAWRGTLARWHCRRLRAIYTIMRWFR 765

  Fly   728 AYKLRSYVQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEW 792
            .:|:|:::.||..|.:.|:|...||:.:.||.||...:..:.....:|..|||..::...|.|:.
Mouse   766 RHKVRAHLIELQRRFQAARQPPLYGRDLVWPTPPAVLQPFQDTCRVLFSRWRARQLVKNIPPSDM 830

  Fly   793 PQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQEN-SGYEAYNGSIKNIRNHPADGETFQQVL 856
            .|::.::.|..||.|.|..||..|.|..|||::..:| :....:...:|.:|.  .||  |..||
Mouse   831 IQIKAKVAAMGALQGLRQDWGCQRAWARDYLSSDTDNPTASHLFAEQLKALRE--KDG--FGSVL 891

  Fly   857 FSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIVFHS 921
            |||.|:|.|.|.|..:||.:::|..::||:. ..:::.| |.:.:..:|.:||:.|||||:|.|:
Mouse   892 FSSHVRKVNRFRKSRDRALLLTDRYLYKLEP-GRQYRVM-RAVPLEAVTGLSVTSGRDQLVVLHA 954

  Fly   922 SKNKDLVFSLESEYTPLKEDRIGEVVGIV---CKKYHDLTGTELRVNVTTNISCRLDGKARIITV 983
            ....|||..|.....|| ::||||:||::   |:.    .|..|.|.|:..|.....|..|:|:|
Mouse   955 QGYDDLVVCLHRSQPPL-DNRIGELVGMLAAHCQG----EGRTLEVRVSDCIPLSQRGARRLISV 1014

  Fly   984 EAASNVEVPNFR 995
            |.......|:|:
Mouse  1015 EPRPEQPEPDFQ 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	383/676 (57%)
		MYSc_Myo1	21..677	CDD:276829	374/663 (56%)
		Myosin_TH1	801..983	CDD:283635	66/185 (36%)
Myo1g	XP_006514763.1	MYSc_Myo1	52..715	CDD:276829	374/663 (56%)
Myo1g	XP_006514763.1	Myosin_TH1	836..1007	CDD:368706	63/181 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833701
Domainoid	1	1.000	823	1.000	Domainoid score	I60
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1063	1.000	Inparanoid score	I253
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53790
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	1	1.000	-	-		otm44016
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2270
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770