Protein Alignment Myo31DF and Myo16

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: XP_006508841.1
• Gene: Myo16 / 244281
• MGIID: 2685951
• Length: 1941
• Species: Mus musculus
• Alignment Length: 995
• Identity: 257/995 - (25%)
• Similarity: 451/995 - (45%)
• Gaps: 179/995 - (17%)

  Fly    11 DFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKY---KGRELFEN 72
            |...|.:::....:..::|||.|..|:|:||::.:.:||::::.||.....:.|   .|:.....
Mouse   426 DLATLSELNDSSLLYEIQKRFGNDQIHTFIGDIFLLVNPFKELPIYSTMVSQMYLSPTGQRSPSL 490

  Fly    73 APHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVLI 137
            .||||:.|:.|:..|.|.::...|::|||.|:|||:|||.||||:.:..::.......|:::.:.
Mouse   491 PPHLFSCAERAFHRLFQERKPQNIILSGERGSGKTQASKQIMKYLTSRASSSCTMFDSRLRHAIY 555

  Fly   138 QSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPV-GGIITNYLLEKSRVVQQQPGERNFHS 201
                |:|.||:|||..|:.||...:|.:::...:...: |..|:.|:|||||||.|.||:..|..
Mouse   556 ----IVEAFGHAKTTLNNVSSCLIQYWELQCCQRRKHITGARISTYMLEKSRVVAQPPGQGTFLI 616

  Fly   202 FYQLLRGANDNELRQYELQKETGKYHYLNQGSM-DILT-----EKSDYKGTCNAFKTLGFSTDEV 260
            |..|:.|.:..|.....|..... :.|::||.. |:.|     .|.......:|...:||||.||
Mouse   617 FSWLMDGLSSEEKCGLHLNNFCA-HRYVSQGMREDVSTAEHSLNKERLAALKHALNVIGFSTLEV 680

  Fly   261 QTIWRTIAAVLHLGNVEFQ--TIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVM 323
            :.::..::|:||:|:::|.  |..|...:|:.|.|:..|.:|||:..||::|||..:....|:|:
Mouse   681 ENLFVILSAILHIGDIQFTALTEADSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDVI 745

  Fly   324 QKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSV----IGVLDIYGFEI 384
            .:.|....|.:.:|.|||::|.|||.::|:.:|..:     :.|..:.|:    ||:|||:|||.
Mouse   746 IRRHTIQMAAFYRDLLAKSLYSRLFGFLINTVNCCL-----QNQDEYKSLQTLDIGILDIFGFEE 805

  Fly   385 FDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEW-TNIEYFNNKIICDLVEQPHKGII 448
            |..|.|||.|:|..|||:.....|::..|||.|..:||:.. |.....|...:.|...|...|..
Mouse   806 FQKNEFEQLCVNLTNEKMHHYIQEVLFLQEQTECVQEGVAMETACSPGNQAGVLDFFFQKPSGFF 870

  Fly   449 AIMDEACLSVGKVTDDTLLGAMDKNL---------SKHPHYTSRQLKPTDKELKHRED---FRIT 501
            :::||         :..::.:.:.||         |.:.:.....:|..:..:..:..   |.:.
Mouse   871 SLLDE---------ESQVIWSGEPNLPRKLQGLLESSNTNAVYSPVKDGNGNVAFKGQGAAFTVM 926

  Fly   502 HYAGDVIYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWP----------------------- 543
            ||||.|:|.:.|.:|:|||:|.|:...::..|::..:|.::.
Mouse   927 HYAGRVMYEMGGAVERNKDSLSQNLLFVMKTSENVVISHLFQSKLSQTGSLISSYPSFKFGGHKS 991

  Fly   544 ---------------EGAQDIKKTTKR--------------PLTAGTLFQRSMADLVVTLLKKEP 579
                           :...::.|..|:              |.||.:...:|:||:...|.:..|
Mouse   992 TLLSKRTASSMVGVNKNYLELSKLLKKKGTSTFLQRLERGEPATAASQLTKSLADITAKLQRGSP 1056

  Fly   580 FYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPN 644
            .::.|||||..:...|||...|..|::|||:|..:|:.|:|:..|..::.||.||:.::......
Mouse  1057 HFILCIKPNTSQLPGVFDHFYVSAQLQYLGVLGLVRLFRSGYPVRPSFEDFLSRYEPLASVLLGE 1121

  Fly   645 FRAGSDRDGVRVLIEEKKFAQDVKYGHTKIFIR----SPRTLFALEHQRNEMIPHIVTLLQKRVR 705
            .:..:..:..|::::..|. |..:.|..|:|::    ...:...|:.||.     ||| .||.:|
Mouse  1122 TKGQAAEERCRLVLQRCKL-QGWQIGVHKVFLKYWHVDQLSDLWLQLQRK-----IVT-CQKVIR 1179

  Fly   706 GWIVRRN-FKKM---KAAITIVRAY---------KAY----------------KLRSYVQELANR 741
            |::.|:: .::|   :..:|.::::         |.|                :||..|....:|
Mouse  1180 GFLARQHLLQRMSIKQQEVTSIKSFLQSTEDMALKTYDALVIQNASDIAREHDRLRKEVHTAYHR 1244

  Fly   742 LRK---AKQMRDYG-----KSIQWPQPPLAGRKVEA---------KLHRMFDFWRANMILHKYPR 789
            .|:   .|:..|.|     .|...|.|.:.....:|         .||.:|....:..:  ..||
Mouse  1245 NRQEEGTKRAEDQGGCRHVHSNSVPVPMVVDSLAQALTGPSTRPPSLHSVFSMDDSTGL--PSPR 1307

  Fly   790 SEWP---------QLRLQIIAATA-LAGRRPYWGQA----RRWVGDYLA------NSQENSGYEA 834
            .:.|         :|.....|.:| |:..:...|:|    |....||..      ...:.|.:..
Mouse  1308 KQPPPKPKRDPNTRLSASYEAVSACLSAAKDAAGEALTRPRPHSDDYSTMKKIPPRKPKRSPHTK 1372

  Fly   835 YNGSIKNIRNHPADGETFQQ 854
            .:||.:.|...|....|..|
Mouse  1373 LSGSYEEIWGPPRPSGTMGQ 1392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	206/736 (28%)
		Myosin_TH1	801..977	CDD:461801	15/65 (23%)
Myo16	XP_006508841.1	ANKYR	81..336	CDD:440430
		ANK repeat	114..145	CDD:293786
		ANK repeat	147..178	CDD:293786
		ANK repeat	180..210	CDD:293786
		ANK repeat	243..274	CDD:293786
		ANK repeat	276..307	CDD:293786
		MYSc_Myo16	436..1153	CDD:276844	206/736 (28%)
		NYAP_N	1235..1605	CDD:464717	33/160 (21%)