DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and Myo1h

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001158045.1	Gene:	Myo1h / 231646	MGIID:	1914674	Length:	1022	Species:	Mus musculus

Alignment Length:	1055	Identity:	392/1055 - (37%)
Similarity:	578/1055 - (54%)	Gaps:	122/1055 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EAGVQDFVLLDQVSMEK-FMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGREL 69
            :.|||||||||..:.|. |::||||||:...||||||.:.||:|||:::.||....:..|:|...
Mouse    10 KVGVQDFVLLDAYTSESAFLENLRKRFRENLIYTYIGTLLVSVNPYQELGIYTASQMELYQGVNF 74

  Fly    70 FENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKN 134
            ||..||::||||:|||::.....:..||||||||||||||||.|::|.|.........:|.|.:
Mouse    75 FELPPHVYAIADNAYRMMCSELNNHFILISGESGAGKTEASKKILQYFAVTCPMTESLQIARDR- 138

  Fly   135 VLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNF 199
             |:.|..:||.||||||.||||||||||||||:||::..||||.|.:||:||||||.|..|||||
Mouse   139 -LLLSIPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFQGVPVGGHIISYLIEKSRVVYQNHGERNF 202

  Fly   200 HSFYQLLRGANDNELRQYELQKETGKYHYLNQGSM---DILTEKSDYKGTCNAFKTLGFSTDEVQ 261
            |.|||||.|.....|....|:::...|.||:||..   ..:::|:|::..|.||..:||:..:::
Mouse   203 HIFYQLLAGGGSERLASLGLERDPQLYKYLSQGHCARESPISDKNDWETVCGAFSVIGFTEADLE 267

  Fly   262 TIWRTIAAVLHLGNVEFQTIEDELV-ISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVMQK 325
            .::..||:|||||||.|:..:.... :.:...:|..||||.|....|..|||.|.|.|....:..
Mouse   268 NLFGIIASVLHLGNVCFKGDKQGCASVPDTHEIKWIAKLLGVCPAVLLEALTHRKIEAKTEEVIC 332

  Fly   326 DHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNSF 390
            ......:.|.:||:|||:|.|.|||:::|||.:::.: ..||   .:|||:|||||||:||.|.|
Mouse   333 PLTVELSVYARDAMAKAVYGRTFTWLVNRINSSLVNK-DFTQ---KTVIGLLDIYGFEVFDKNGF 393

  Fly   391 EQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDEAC 455
            |||||||||||||||.||..||.||.||:.|||||..::||||||||||||:.|:|||:|:||.|
Mouse   394 EQFCINYCNEKLQQLLIERTLKAEQAEYESEGIEWETVQYFNNKIICDLVEERHRGIISILDEEC 458

  Fly   456 LSVGKVTDDTLLGAMDKNLSKHPHYTSRQLK-PTDKELKHREDFRITHYAGDVIYNINGFIEKNK 519
            :..|..||.:.|..:::.:.||.|:.:|:|. |..::.....:|.:.||||:|.|...||:|||.
Mouse   459 IRPGPATDLSFLEKLEEKVGKHAHFQTRKLAGPKGRKRIGWLEFCLLHYAGEVTYCTKGFLEKNN 523

  Fly   520 DTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKKEPFYVRC 584
            |.||:..|.:|.:||::.|.|.:.....:   ..:||.|.||.|:.|::.|:..|:.|||.|:||
Mouse   524 DLLYRHLKEVLCSSKNSILRECFLVAELE---NRRRPPTVGTQFKNSLSSLLEILISKEPSYIRC 585

  Fly   585 IKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAGS 649
            ||||:.|..:.||:..:.||::||||:|:||||||||.:|::|:.||.|||.:...|||::. |.
Mouse   586 IKPNERKEPSKFDDFLISHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWPHWH-GP 649

  Fly   650 DRDGVRVLIEEKKF-AQDVKYGHTKIFIRSPRTLFALE-------HQRNEMIPHIVTLLQKRVRG 706
            ..:||..||:...: .||.|.|.||||||.||||||.|       ||       :|:.:|...:|
Mouse   650 PGEGVERLIKYIGYQPQDYKLGKTKIFIRFPRTLFATEDAFEFSKHQ-------LVSRIQATYKG 707

  Fly   707 WIVRRNFKKMKAAITIVRAY-------KAYKLRSYVQELANRLRKAKQMRD-------------- 750
            .:.||.:.|.:.|.|.:.|:       |..|.|.:..::..|..|....||
Mouse   708 CLGRREYMKKRQAATKLEAHWRGVLARKEIKRRRWAVQIIRRFVKGFINRDKPLCPDNEEFVVLV 772

  Fly   751 -----------YGKSI---QWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPR----SEWPQLRL 797
                       ..|::   .|.:||.........|.||.    ...::.||.|    .....::.
Mouse   773 RKNYILNLRYHVPKNVLDKSWLRPPGILENASNLLRRMC----TRNLVRKYCRGISAERKAMMQQ 833

  Fly   798 QIIAATALAGRRPYWGQA--RRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSF 860
            :::.:....|::..:.::  :.:.|..|..|..|.......||              :::.:...
Mouse   834 KVVTSEIFRGKKEGYAESLNQLFAGSRLDESNINPKVLQLLGS--------------EKIQYGVP 884

  Fly   861 VKKFNHFN-KQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIVFHSSKN 924
            |.|::... |...|..:::..:.:.::     ...:|:.|:...:..:|.|...|.::|.|.|
Mouse   885 VIKYDRKGFKARQRQLLLTQRSAYLVE-----LSKVKQKIEYAAVRGVSTSSLSDGILVIHIS-- 942

  Fly   925 KDLVFSLESEYTPLKEDRIGEVVGIVCKKYHDLTGTELRVNVTTNISCRLDGKARIITVEAASNV 989
                        |..:.:.|:|: :.|:...:         |.|.::..:..:..:..|:.:...
Mouse   943 ------------PADKQQKGDVI-LQCEHIFE---------VATKLAMLIRKEHTVRVVQGSLQF 985

  Fly   990 EVPNFRPKEGNIIFE 1004
            .|...|  ||.|:||
Mouse   986 YVSPGR--EGTIVFE 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	333/697 (48%)
		MYSc_Myo1	21..677	CDD:276829	313/662 (47%)
		Myosin_TH1	801..983	CDD:283635	25/184 (14%)
Myo1h	NP_001158045.1	MYSc	8..689	CDD:214580	331/688 (48%)
		MYSc_Myo1	26..678	CDD:276829	312/661 (47%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	568..590		11/21 (52%)
		Myosin_TH1	834..1001	CDD:283635	33/210 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820