Protein Alignment Myo31DF and hum-6

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: NP_508420.1
• Gene: hum-6 / 180539
• WormBaseID: WBGene00002039
• Length: 2098
• Species: Caenorhabditis elegans
• Alignment Length: 1097
• Identity: 337/1097 - (30%)
• Similarity: 547/1097 - (49%)
• Gaps: 202/1097 - (18%)

  Fly     8 GVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFEN 72
            ||:|...|........:.||..|::...||.|.|.:.:::|||..:.||..:.||.||.:.:.|.
 Worm    63 GVEDMCQLGDFHESAILRNLFIRYREKLIYAYTGSILIAVNPYMDIAIYTADEIRMYKRKRIGEL 127

  Fly    73 APHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVLI 137
            .||:|||||:||..:::.:::..::|||||||||||::|::::::|.::   ||:  ..::..::
 Worm   128 PPHIFAIADNAYTNMRREKKNQSVIISGESGAGKTESTKLVLQFLATIS---GQH--SWIEQQVL 187

  Fly   138 QSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHSF 202
            ::|.:||.||||||.|||||||||||:|:.|:......|..|..|||||||:|.|...|||:|.|
 Worm   188 EANPVLEAFGNAKTIRNDNSSRFGKYIDVHFNESGSIEGAKIEQYLLEKSRIVTQSENERNYHIF 252

  Fly   203 YQLLRGANDNELRQYELQKETGKYHYLNQGSMDILT-----EKSDYKGTCNAFKTLGFSTDEVQT 262
            |.||.|.:..|..:.|| .....|:||.||.  .||     :.:|.....:|.:.|..:..|:.:
 Worm   253 YCLLAGLSREEKSELEL-GTAADYYYLIQGK--TLTAEGRDDAADLAEIRSAMRVLMINEQEIGS 314

  Fly   263 IWRTIAAVLHLGNVEF-QTIEDELV---ISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVM 323
            |::.:|::||:||:.| |...|.:.   :::...|...|||||:.|..|..|:|.:.:......:
 Worm   315 IFKLLASLLHIGNIRFRQNTNDNMESVDVADPSTLVRIAKLLQLHEQNLLDAITTKSLVTREERV 379

  Fly   324 QKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSN 388
            ....|..||...:||||||||.:||..|:.|:|.||.   ..:|:|..| ||:|||:|||.|:||
 Worm   380 ISRLNGQQAVDARDALAKAIYGKLFIHIVRRVNDAIY---KPSQSRRTS-IGILDIFGFENFESN 440

  Fly   389 SFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDE 453
            ||||.|||:.||.|||.|:..|.|.||:||..|.|.|.:|::.:|:...||:.|....|::::||
 Worm   441 SFEQLCINFANETLQQFFVHHVFKMEQKEYDEEHINWRHIKFVDNQATVDLIAQRPLNILSLIDE 505

  Fly   454 ACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFIEKN 518
            ..: ..|.||.|:|..:.....::..|    |:| ..||:..  |.:||:||:|.||..||:|||
 Worm   506 ESI-FPKGTDKTMLLKLHSTHGRNELY----LQP-KSELQRA--FGVTHFAGNVFYNTRGFLEKN 562

  Fly   519 KDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKKEPFYVR 583
            :|:...|...|:.:||...|:.::.:...|  .::::.:|.|..|:||:..|:..|.:..||::|
 Worm   563 RDSFSADLSVLISSSKMPFLARLFDDIEYD--TSSRKKVTVGNQFRRSLEQLMSQLTQTHPFFIR 625

  Fly   584 CIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYK-MISQYTWPNFRA 647
            |||||::|.:.|.|.:.|..|:||.|::|.:::||:|:..|..|..|:.||: ::|....|..|
 Worm   626 CIKPNEMKRALVMDRDLVLRQLRYSGMMETIKIRRSGYPIRHDYYPFVFRYRVLVSSIQGPVNR- 689

  Fly   648 GSDRDGVRVLIEEKKFAQ-------DVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVR 705
                  :.:....||...       |.:.|.||:|::....| .||.:...::.....::||.||
 Worm   690 ------IDLHDAAKKICHMILGTNADYQLGKTKVFLKDKHDL-VLEQEYYRILKDKAIVIQKNVR 747

  Fly   706 GWIVRRNFKKMK-AAITIVRAYKAYKLRSYVQELA---NRLR---KAKQMRDYGKS-----IQWP 758
            .|:||::|:|.: ||:||..|::.:..|...:::.   :||:   :::|:..:.::     ||:.
 Worm   748 RWLVRKDFEKQRQAAVTIQTAWRGFDQRKRYRQIISGFSRLQAVLRSRQLVSHYQTLRKTIIQFQ 812

  Fly   759 ---QPPLAGRKVEAKLHR--------------------------MFDFW---------------- 778
               :..|..|:|..|..|                          :|||.
 Worm   813 AVCRGSLVRRQVGEKRKRGEKAPLTEVSSTASVISDSHEELVGHLFDFLPSDGKDSGNENDSADS 877

  Fly   779 ----------------RANM---------ILHKYPRSEWPQLRLQIIAATALAGRRPY------- 811
                            .||:         .|.||...::.....| ..|||...::|.
 Worm   878 SRRGSYSRLHTSPVMPPANIPRVDSYVDEDLSKYQFGKYAATFFQ-AQATATHVKKPLKTALLTH 941

  Fly   812 ------------WGQARRWVGDYLANSQENS--GYEAYNGSIKNIRNHPADGETFQQVLFSSFVK 862
                        |....|::|| ||:.:..|  |.|.|:.:...|:            |:::..|
 Worm   942 TEPSAQLAALTAWTTILRFMGD-LADVKPGSTNGSEVYDKTPVMIK------------LYATLGK 993

  Fly   863 KFNHFNKQANRAFIVSD----STIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIVFHSSK 923
            ||:..:.:  .|.:.|:    .|:.|..|.|.....:||..||.         |.|.     ||.
 Worm   994 KFSAHDLE--EAMLSSEYGGAKTLKKGMGRKLISMTLKRKGKIN---------GSDT-----SSI 1042

  Fly   924 NKDLVFS-----LESEYTPLKE-DRIGEVVGIVCKKYHDLTGTELRVNVTTNISCRL 974
            :.|.|:|     ||::  |:.. |::..::|:..          ||.::...|.|:|
 Worm  1043 SSDSVYSSFNAMLENK--PMTSLDKLHYIIGLGI----------LREDLRDEIYCQL 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	250/672 (37%)
		Myosin_TH1	801..977	CDD:461801	46/205 (22%)
hum-6	NP_508420.1	MYSc_Myo7	76..720	CDD:276832	250/672 (37%)
		CBD_MYO6-like	738..>808	CDD:409646	18/69 (26%)
		IQ	757..779	CDD:197470	7/21 (33%)
		MyTH4	929..1168	CDD:214535	43/200 (22%)
		FERM1_F1_Myosin-VII	1172..1270	CDD:340612
		B41	1174..1388	CDD:214604
		FERM_C1_MyoVII	1382..1480	CDD:270019
		SH3	1481..1544	CDD:473055
		MyTH4	1624..1772	CDD:214535
		FERM2_F1_Myosin-VII	1777..1875	CDD:340613
		B41	1779..1993	CDD:214604
		FERM_C2_MyoVII	1989..2087	CDD:270020