DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and Myo7a

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	XP_011239990.1	Gene:	Myo7a / 17921	MGIID:	104510	Length:	2250	Species:	Mus musculus

Alignment Length:	833	Identity:	295/833 - (35%)
Similarity:	465/833 - (55%)	Gaps:	70/833 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GVQDFVLLDQVSMEKFMDNLRKRFQNGSIY------TYIGEVCVSMNPYRQMNIYGPETIRKYKG 66
            ||:|.:.|..::....:.||..|:::..||      ||.|.:.|::|||:.::||.||.||:|..
Mouse    95 GVEDMIRLGDLNEAGILRNLLIRYRDHLIYTSCGGRTYTGSILVAVNPYQLLSIYSPEHIRQYTN 159

  Fly    67 RELFENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIER 131
            :::.|..||:|||||:.|..:|:..:|.|.:|||||||||||::|:|::::||::   ||:  ..
Mouse   160 KKIGEMPPHIFAIADNCYFNMKRNNRDQCCIISGESGAGKTESTKLILQFLAAIS---GQH--SW 219

  Fly   132 VKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGE 196
            ::..::::..|||.||||||.|||||||||||:||.|:.:....|..|..||||||||.:|.|.|
Mouse   220 IEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQAPDE 284

  Fly   197 RNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQG---SMDILTEKSDYKGTCNAFKTLGFSTD 258
            ||:|.||.:|.|.|:.|.::..| .:...|:||..|   :.:...:..:|....:|.|.|.|:..
Mouse   285 RNYHVFYCMLEGMNEEEKKKLGL-GQAADYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDT 348

  Fly   259 EVQTIWRTIAAVLHLGNVEFQ--TIED----ELVISNKQHLKSTAKLLQVTETELSTALTKRVIA 317
            |...|.:.:||:||:||::::  |.|:    |::.|  ..|.:.|.||:|...:|.:.||.|.:.
Mouse   349 ENWEISKLLAAILHMGNLQYEARTFENLDACEVLFS--PSLATAASLLEVNPPDLMSCLTSRTLI 411

  Fly   318 AGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNS--VIGVLDIY 380
            ..|..:....:..||...:||..|.||.|||.||:.:||.|| ::....:.: ||  .||:|||:
Mouse   412 TRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVEKINAAI-YKPPPLEVK-NSRRSIGLLDIF 474

  Fly   381 GFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHK 445
            |||.|..|||||.|||:.||.|||.|:..|.|.|||||..|.|:|.:||:.:|:...|::.....
Mouse   475 GFENFTVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQEALDMIANRPM 539

  Fly   446 GIIAIMDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYN 510
            .:|:::||.. ...|.||.|:|..::.....:.:|    :.|.:   .|...|.|.|:||.|.|.
Mouse   540 NVISLIDEES-KFPKGTDATMLHKLNSQHKLNANY----VPPKN---SHETQFGINHFAGVVYYE 596

  Fly   511 INGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLL 575
            ..||:|||:|||:.|..:|:|:|::..:.:::........:|.||..|..:.|:||:..|:.||.
Mouse   597 SQGFLEKNRDTLHGDIIQLVHSSRNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLG 661

  Fly   576 KKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQY 640
            ..:||:|||||||:.|...:||......|:||.|::|.:|:|.||:..|..:.:|:.||:::...
Mouse   662 ACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRHAGYPIRYSFVEFVERYRVLLPG 726

  Fly   641 TWPNFRAGSDRDGVRVLIEEKKFA-QDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRV 704
            ..|.::.|..|...:.:.|..... .|.:.|.||||::....:. ||.:|::.|...|.||||.:
Mouse   727 VKPAYKQGDLRGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDML-LEVERDKAITDRVILLQKVI 790

  Fly   705 RGWIVRRNFKKMKAAITIV----------RAYKAYKLRSYVQELANRLRKA-KQMRDYGKSIQWP 758
            ||:..|.||.::|:|.|::          :.|:..:|.....:..:|.||. ||.|
Mouse   791 RGFKDRSNFLRLKSAATLIQRHWRGHHCRKNYELIRLGFLRLQALHRSRKLHKQYR--------- 846

  Fly   759 QPPLAGRKVEAKLHRMFDF---WRANMILHKYPRSEWPQLRLQIIAATALAGR 808
               ||.:       |:.:|   .||.::...:....|..:.:|..|...:|.|
Mouse   847 ---LARQ-------RIIEFQARCRAYLVRKAFRHRLWAVITVQAYARGMIARR 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	261/699 (37%)
		MYSc_Myo1	21..677	CDD:276829	255/673 (38%)
		Myosin_TH1	801..983	CDD:283635	3/8 (38%)
Myo7a	XP_011239990.1	MYSc_Myo7	108..764	CDD:276832	255/673 (38%)
		IQ	801..822	CDD:197470	3/20 (15%)
		PTZ00121	<838..>1010	CDD:173412	16/71 (23%)
		MAP7	<892..970	CDD:368554
		MyTH4	1052..1288	CDD:214535
		FERM1_F1_Myosin-VII	1292..1390	CDD:340612
		B41	1294..1509	CDD:214604
		FERM_C1_MyoVII	1503..1639	CDD:270019
		SH3_MYO7A	1640..1704	CDD:212814
		MyTH4	1782..1931	CDD:214535
		FERM2_F1_Myosin-VII	1936..2033	CDD:340613
		B41	1938..2150	CDD:214604
		FERM_C2_MyoVII	2146..2241	CDD:270020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910