DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo31DF and Myo1f

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_444444.2	Gene:	Myo1f / 17916	MGIID:	107711	Length:	1098	Species:	Mus musculus

Alignment Length:	1012	Identity:	357/1012 - (35%)
Similarity:	523/1012 - (51%)	Gaps:	167/1012 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 REAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGREL 69
            :::||.|.|||.|::.:..:.||||||.:..|:||||.|.:|:||::||..:....|..|:|...
Mouse    15 KQSGVDDMVLLPQITEDAIVSNLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLYQGAAQ 79

  Fly    70 FENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKN 134
            :||.||::|:.|:.||.:....::.|::||||||||||.|:|.||.||:.|:.  |.::::.||:
Mouse    80 YENPPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISKVSG--GGDKVQHVKD 142

  Fly   135 VLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNF 199
            :::|||.:||.||||||.||:||||||||.:|:|....:|.||.|:|:||||||||.|...||||
Mouse   143 IILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNENERNF 207

  Fly   200 HSFYQLLRGANDNELRQYELQKETG-----KYHYLNQG---SMDILTEKSDYKGTCNAFKTLGFS 256
            |.:||||.||:.      |.|:..|     .|:||||.   .::...::||:..|.:|.:.:|..
Mouse   208 HIYYQLLEGASQ------EQQQNLGLMTPDYYYYLNQSDTYKVEGTDDRSDFSETLSAMQVIGIP 266

  Fly   257 TDEVQTIWRTIAAVLHLGNVEFQTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAA--G 319
            |...|.:.:.:|.:|||||:.|....:...:.:...|...|.||.:....|...||.|.:.:  |
Mouse   267 TSVQQLVLQLVAGILHLGNISFCEEGNYARVESVDLLAFPAYLLGIDSGRLQEKLTSRKMDSKWG 331

  Fly   320 GNVMQKD--HNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGF 382
            |.....|  .|..||.|.:|||||.:|.|||.:::..||||:    .|.|..::  |||||||||
Mouse   332 GRSESIDVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAM----QKPQEEYS--IGVLDIYGF 390

  Fly   383 EIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQ--PHK 445
            |||..|.|||||||:.||||||:||||.||.|||||.:|||.||.||||||||:|||:|.  ...
Mouse   391 EIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKLSPP 455

  Fly   446 GIIAIMDEACLSV---GKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDV 507
            ||::::|:.|.::   |...|.|||..:...:..|.|:.|           ....|.|.||||.|
Mouse   456 GIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNS-----------WSAGFVIHHYAGKV 509

  Fly   508 IYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVV 572
            .|:::||.|:|:|.|:.|...|:.:|....|..::||.....||  .||.|||:..::...|||.
Mouse   510 SYDVSGFCERNRDVLFSDLIELMQSSDQDFLRMLFPEKLNIDKK--GRPSTAGSKIKKQANDLVS 572

  Fly   573 TLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMI 637
            ||.|..|.|:||||||:.|....::|.||:|||.||||.||:|||||||.:|:::.|||.||.::
Mouse   573 TLKKCTPHYIRCIKPNETKRPRDWEESRVKHQVEYLGLRENIRVRRAGFAYRRQFSKFLQRYAIL 637

  Fly   638 SQYTWPNFRAGSDRDGVRVLIEEKKFAQD-VKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQ 701
            :..|||.:| |.:|.||:.|:.......| .:.|.||:|:::|.:||.||..|..........:|
Mouse   638 TPETWPRWR-GDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESLFLLEEMRERKFDGFARTIQ 701

  Fly   702 KRVRGWIVRRNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQMRDYGKSIQWPQPPLAGRK 766
            |..|..:..|.:::|:                  :|.:|.|...|:.
Mouse   702 KAWRRHVAVRKYEEMR------------------EEASNILLNKKER------------------ 730

  Fly   767 VEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQENSG 831
                        |.|.|                               .|.:|||||...:.
Mouse   731 ------------RRNSI-------------------------------NRNFVGDYLGLEER--- 749

  Fly   832 YEAYNGSIKNIRNHPADGETFQQVLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKD-- 894
                    ..:|...|..|   :|.|:..|.|::...|...|..|::...::.:.  :.|.|.
Mouse   750 --------PELRQFLAKRE---RVDFADSVTKYDRRFKPIKRDLILTPKCVYVIG--REKVKRGP 801

  Fly   895 --------MKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFSLESEYTPLKEDRIGEVVGIVC 951
                    :|:.:.|:.|..:|:|..:|...:.........   |||.:..       |.|.::|
Mouse   802 EKGLVREVLKKKLDIQALRGVSLSTRQDDFFILQEEAADSF---LESIFKT-------EFVSLLC 856

  Fly   952 KKYHDLTGTELRVNVTTNISCRL------DGKARIIT 982
            |::.:.....|.:..:..:..|:      .|..|.:|
Mouse   857 KRFEEAARRPLPLTFSDLLQFRVKKEGWGGGSTRNVT 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	308/701 (44%)
		MYSc_Myo1	21..677	CDD:276829	296/673 (44%)
		Myosin_TH1	801..983	CDD:283635	36/198 (18%)
Myo1f	NP_444444.2	MYSc	12..690	CDD:214580	308/702 (44%)
		MYSc_Myo1	31..677	CDD:276829	296/673 (44%)
		Myosin_TH1	717..897	CDD:283635	43/282 (15%)
		SH3_MyoIe_If_like	1045..1097	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2201
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850