Protein Alignment Myo31DF and Myo1c

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: NP_001357540.1
• Gene: Myo1c / 17913
• MGIID: 106612
• Length: 1063
• Species: Mus musculus
• Alignment Length: 1067
• Identity: 428/1067 - (40%)
• Similarity: 599/1067 - (56%)
• Gaps: 147/1067 - (13%)

  Fly     8 GVQDFVLLDQVSME-KFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFE 71
            ||||||||:..:.| .|::|||:||:...||||||.|.||:||||.:.||..:.:.:|:|...:|
Mouse    47 GVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYE 111

  Fly    72 NAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIER---VK 133
            ..|||||:||:.||.|:..::|..::||||||||||||:|.::::.|....|.     ||   |:
Mouse   112 VPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAP-----ERGGAVR 171

  Fly   134 NVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERN 198
            :.|:|||.:||.||||||.|||||||||||||::||:|..||||.|.:|||||||||.|..||||
Mouse   172 DRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERN 236

  Fly   199 FHSFYQLLRGANDNELRQYELQKETGKYHYLNQG---SMDILTEKSDYKGTCNAFKTLGFSTDEV 260
            ||.|||||.|..:..||:..|::....|.||.:|   .:..:.:|||:|....|...:.|:.|||
Mouse   237 FHVFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVMRKALSVIDFTEDEV 301

  Fly   261 QTIWRTIAAVLHLGNVEFQTIED-ELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVMQ 324
            :.:...:|:||||||:.|...|| ...::.:..||...:||.|..|.|..|||.|.|.|.|..:.
Mouse   302 EDLLSIVASVLHLGNIHFAADEDSNAQVTTENQLKYLTRLLGVEGTTLREALTHRKIIAKGEELL 366

  Fly   325 KDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQA-RFNSVIGVLDIYGFEIFDSN 388
            ...|..||.|.:||||||:|.|.|||::.:|||::..:.:::.: |..:|:|:|||||||:|..|
Mouse   367 SPLNLEQAAYARDALAKAVYSRTFTWLVRKINRSLASKDAESPSWRSTTVLGLLDIYGFEVFQHN 431

  Fly   389 SFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDE 453
            |||||||||||||||||||||.||.|||||:.|||.|..::||||||||||||:..||||:|:||
Mouse   432 SFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDE 496

  Fly   454 ACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQL--KPTDKELKHREDFRITHYAGDVIYNINGFIE 516
            .||..|:.||.|.|..::..:..|||:.:.:|  :.|.|.| .|.:||:.||||:|.|::.||::
Mouse   497 ECLRPGEATDLTFLEKLEDTVKPHPHFLTHKLADQKTRKSL-DRGEFRLLHYAGEVTYSVTGFLD 560

  Fly   517 KNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKT----TKRPLTAGTLFQRSMADLVVTLLKK 577
            ||.|.|::       |.|:...|.|.|..||...|:    .|||.|..|.|:.|:..||..|..|
Mouse   561 KNNDLLFR-------NLKETMCSSMNPIMAQCFDKSELSDKKRPETVATQFKMSLLQLVEILRSK 618

  Fly   578 EPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTW 642
            ||.|:|||||||.|....|||..:.|||:||||:||||||||||.:|::|:.||.|||.:...||
Mouse   619 EPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRKYEAFLQRYKSLCPETW 683

  Fly   643 PNFRAGSDRDGVRVLIEEKKF-AQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRG 706
            |.: ||..:|||.||:....: .::.|.|.||||||.|:||||.|.........:.|.:|...||
Mouse   684 PMW-AGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDSLEVRRQSLATKIQAAWRG 747

  Fly   707 WIVRRNFKKMK------------------------AAITIVRAYKAYKLR--------------- 732
            :..|:.|.::|                        ||.||.|..:.:.||
Mouse   748 FHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFILRHSPRCPENAFFLDHV 812

  Fly   733 --SYVQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRS---EW 792
              |::..|..:|  .:.:.|    ..||.||.|.|:....|.   :....||: .||.||   ||
Mouse   813 RASFLLNLRRQL--PRNVLD----TSWPTPPPALREASELLR---ELCMKNMV-WKYCRSISPEW 867

  Fly   793 -PQLRLQIIAATALAGRRPYWGQA--RRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQ 854
             .||:.:.:|:....|::..:.|:  |.::...|...      |.....::::.:.|
Mouse   868 KQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTE------EISPRVLQSLGSEP-------- 918

  Fly   855 VLFSSFVKKFNHFN-KQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIV 918
            :.::..|.|::... |...|..:::.|.:..::..|     :|:.|....||.||||...|.|.|
Mouse   919 IQYAVPVVKYDRKGYKPRPRQLLLTPSAVVIVEDAK-----VKQRIDYANLTGISVSSLSDSLFV 978

  Fly   919 FH----SSKNK-DLVFSLESEY-------TPLKEDRIGEV---------------VGIVCKKYHD 956
            .|    .:|.| |:|  |:|::       |.|..||:..:               .||:     |
Mouse   979 LHVQREDNKQKGDVV--LQSDHVIETLTKTALSADRVNNININQGSITFAGGPGRDGII-----D 1036

  Fly   957 LT-GTELRVNVTTN-----ISCRLDGK 977
            .| |:||.:....|     ::.||:.:
Mouse  1037 FTSGSELLITKAKNGHLAVVAPRLNSR 1063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	332/671 (49%)
		Myosin_TH1	801..977	CDD:461801	45/211 (21%)
Myo1c	NP_001357540.1	MYSc_Myo1	62..718	CDD:276829	331/669 (49%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	608..630		12/21 (57%)
		IQCG	751..781	CDD:467744	3/29 (10%)
		Myosin_TH1	874..1055	CDD:461801	43/206 (21%)