DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and Myh4

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_034985.2	Gene:	Myh4 / 17884	MGIID:	1339713	Length:	1939	Species:	Mus musculus

Alignment Length:	1038	Identity:	304/1038 - (29%)
Similarity:	486/1038 - (46%)	Gaps:	164/1038 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73
            ::|..::..:.....:.||::|:....||||.|..||::|||:.:.:|.||.:..|:|::..|..
Mouse    88 IEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAP 152

  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIA--AVTNAQGQNEIE------ 130
            ||:|:|:|:||:.:...:::..|||:||||||||..:|.:::|.|  |||..:.:.|..
Mouse   153 PHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEEATSGKMQG 217

  Fly   131 RVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPG 195
            .:::.:|.:|.:||.||||||.||||||||||::.|.|..........|..||||||||..|...
Mouse   218 TLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLKA 282

  Fly   196 ERNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQGSMDI--LTEKSDYKGTCNAFKTLGFSTD 258
            ||::|.|||::.......:....:......:.|::||.:.:  :.::.:...|..|...||||.|
Mouse   283 ERSYHIFYQIMSNKKPELIEMLLITTNPYDFAYVSQGEITVPSIDDQEELMATDTAVDILGFSAD 347

  Fly   259 EVQTIWRTIAAVLHLGNVEF-------QTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVI 316
            |...|::...||:|.||::|       |...|...:::|     .|.|..:...:|..||....:
Mouse   348 EKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADK-----AAYLTSLNSADLLKALCYPRV 407

  Fly   317 AAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYG 381
            ..|...:.|.....|......||||::|:::|.|:::|||:.:     .|:......||||||.|
Mouse   408 KVGNEYVTKGQTVQQVYNSVGALAKSMYEKMFLWMVTRINQQL-----DTKQPRQYFIGVLDIAG 467

  Fly   382 FEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIIC-DLVEQPHK 445
            |||||.|:.||.|||:.||||||.|...:...|||||::|||:|..|::..:...| :|:|:| .
Mouse   468 FEIFDFNTLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLAACIELIEKP-M 531

  Fly   446 GIIAIMDEACLSVGKVTDDTLLGAM-DKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIY 509
            ||.:|::|.|: ..|.||.:....: :::|.|..::.    ||...:.|....|.:.||||.|.|
Mouse   532 GIFSILEEECM-FPKATDTSFKNKLYEQHLGKSNNFQ----KPKPAKGKAEAHFSLVHYAGTVDY 591

  Fly   510 NINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWP----------EGAQDIKKTTKRPLTAGTLFQ 564
            ||.|:::||||.|.:....|...|....|:.::.          .|.:..||......|...||:
Mouse   592 NIIGWLDKNKDPLNETVVGLYQKSGLKTLAFLFSGGQAAEAEGGGGKKGGKKKGSSFQTVSALFR 656

  Fly   565 RSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDK 629
            .::..|:..|....|.:|||:.||:.|:....:.|.|.||:|..|:||.:|:.|.||..|..|..
Mouse   657 ENLNKLMTNLKSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYAD 721

  Fly   630 FLLRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQDV-----------KYGHTKIFIRSPRTLF 683
            |..|||:::....|..:          .|:.||.::.:           |:||||:|.:: ..|.
Mouse   722 FKQRYKVLNASAIPEGQ----------FIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKA-GLLG 775

  Fly   684 ALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMK-------------AAITIVRAYKAYKLRSYV 735
            .||..|:|.:..::|..|...||:::|..||||.             .|...|:.:...||...:
Mouse   776 TLEEMRDEKLAQLITRTQAVCRGYLMRVEFKKMMERRESIFCIQYNVRAFMNVKHWPWMKLYFKI 840

  Fly   736 QELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQII 800
            :.|.......|:|.:..:..:..:..||  |.|||...:.:...|.|       .|...|:||:.
Mouse   841 KPLLKSAETEKEMANMKEDFEKAKEDLA--KSEAKRKELEEKMVALM-------QEKNDLQLQVQ 896

  Fly   801 AATALAGRRPYWGQARRWVGDYLANSQENSG--------YEAYNGSIKNIRNHPADGETFQQVLF 857
            |.                 .|.||:::|...        .||   .||.:.....|.|.....|.
Mouse   897 AE-----------------ADGLADAEERCDQLIKTKIQLEA---KIKELTERAEDEEEINAELT 941

  Fly   858 SSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIVFHSS 922
            :                         |...::::..::|:.|...|||...|...:      |::
Mouse   942 A-------------------------KKRKLEDECSELKKDIDDLELTLAKVEKEK------HAT 975

  Fly   923 KNKDLVFSLESEYTPLKEDRIGEVVGIVCKK----------YHDLTGTELRVNVTTNISCRLD 975
            :||  |.:|..|...|.|:    :..:..:|          ..||...|.:||..|....:|:
Mouse   976 ENK--VKNLTEEMAGLDEN----IAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKLE 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	239/720 (33%)
		MYSc_Myo1	21..677	CDD:276829	235/695 (34%)
		Myosin_TH1	801..983	CDD:283635	35/193 (18%)
Myh4	NP_034985.2	Myosin_N	35..73	CDD:308391
		MYSc_Myh4	100..770	CDD:276879	235/695 (34%)
		Actin-binding. /evidence=ECO:0000250	659..681		7/21 (33%)
		Actin-binding. /evidence=ECO:0000250	761..775		6/14 (43%)
		SMC_N	850..1927	CDD:330553	49/249 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1128..1147
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1153..1172
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1276..1299
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000