DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and Myh3

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001093105.1	Gene:	Myh3 / 17883	MGIID:	1339709	Length:	1940	Species:	Mus musculus

Alignment Length:	1072	Identity:	306/1072 - (28%)
Similarity:	511/1072 - (47%)	Gaps:	178/1072 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73
            ::|..:|..::....:.||:.|:.:..||||.|..||::|||:.:.:|.||.:..|:|::..|..
Mouse    88 IEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVDGYRGKKRQEAP 152

  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIA--AVTNAQGQNEIERVKNVL 136
            ||:|:|:|:||:.:...:::..|||:||||||||..:|.:::|.|  |.|....:.:..::|..|
Mouse   153 PHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTL 217

  Fly   137 ----IQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGER 197
                |.:|.:||.||||||.||||||||||::.|.|..........|..||||||||..|...||
Mouse   218 EDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAER 282

  Fly   198 NFHSFYQLLRGANDNELRQYELQKETGKYHYLNQGSMDI--LTEKSDYKGTCNAFKTLGFSTDEV 260
            ::|.|||:|.......:....:......|.:::||.:.:  :.:..:...|.:|...|||:.:|.
Mouse   283 SYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDILGFTPEEK 347

  Fly   261 QTIWRTIAAVLHLGNVEF-------QTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAA 318
            ..:::...||:|.||::|       |...|...:::|     ||.|:.:..::|..||....:..
Mouse   348 SGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADK-----TAYLMGLNSSDLLKALCFPRVKV 407

  Fly   319 GGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFE 383
            |...:.|.....|..:..:||:|::|::||.|:::|||:.:     .|:......||||||.|||
Mouse   408 GNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQL-----DTKLPRQHFIGVLDIAGFE 467

  Fly   384 IFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIIC-DLVEQPHKGI 447
            ||:.||.||.|||:.||||||.|...:...|||||::||||||.|::..:...| :|:|:| .||
Mouse   468 IFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKP-MGI 531

  Fly   448 IAIMDEACLSVGKVTDDTLLGAM-DKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNI 511
            .:|::|.|: ..|.||.:....: |::|.|..::.    ||...:.|....|.:.||||.|.|::
Mouse   532 FSILEEECM-FPKATDTSFKNKLYDQHLGKSNNFQ----KPKVVKGKAEAHFSLVHYAGTVDYSV 591

  Fly   512 NGFIEKNKDTLYQDFKRLLHNSKDANLSEMW-------PEGAQDIKKTTKRP----LTAGTLFQR 565
            :|::|||||.|.:....|...|.:..|:.::       .:|.:  ||..|:.    .|...||:.
Mouse   592 SGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATTDADGGK--KKVAKKKGSSFQTVSALFRE 654

  Fly   566 SMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKF 630
            ::..|:..|....|.:||||.||:.|:....:...|.||:|..|:||.:|:.|.||.:|..|..|
Mouse   655 NLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDF 719

  Fly   631 LLRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQDV-----------KYGHTKIFIRSPRTLFA 684
            ..||::::....|..:          .|:.||..:.:           |:||||:|.:: ..|..
Mouse   720 KQRYRVLNASAIPEGQ----------FIDSKKACEKLLASIDIDHTQYKFGHTKVFFKA-GLLGT 773

  Fly   685 LEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKM---KAAITIVRAYKAYKLRSY------------ 734
            ||..|:|.:..::|..|...||:::|..|:||   :.:|..::    |.:|::
Mouse   774 LEEMRDERLAKLITRTQAVCRGFLMRVEFQKMMQRRESIFCIQ----YNIRAFMNVKHWPWMKLF 834

  Fly   735 --VQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRL 797
              ::.|.......|:|....:..|..:..||  |.||| .:..:.....::..|      ..|:|
Mouse   835 FKIKPLLKSAETEKEMATMKEEFQKTKDELA--KSEAK-RKELEEKLVTLVQEK------NDLQL 890

  Fly   798 QIIAATALAGRRPYWGQARRWVGDYLANSQENSG--------YEAYNGSIKNIRNHPADGETFQQ 854
            |:.|.:                 :.|.:::|...        .||   .||.:.....|.|....
Mouse   891 QVQAES-----------------ENLLDAEERCDQLIKAKFQLEA---KIKEVTERAEDEEEINA 935

  Fly   855 VLFSSFVKKFNHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIVF 919
            .|.:                         |...::::..::|:.|...|||...|...:
Mouse   936 ELTA-------------------------KKRKLEDECSELKKDIDDLELTLAKVEKEK------ 969

  Fly   920 HSSKNKDLVFSLESEYTPLKEDRIGEVVGIVCKK----------YHDLTGTELRVNVTTNISCRL 974
            |:::||  |.:|..|...|.|    .:..:..:|          ..||...|.:||..:.:..:|
Mouse   970 HATENK--VKNLTEELAGLDE----TIAKLTREKKALQEAHQQTLDDLQAEEDKVNSLSKLKSKL 1028

  Fly   975 DGKARII--TVEAASNVEVP---NFRPKEGNI 1001
            :.:...:  ::|....:.|.   |.|..||::
Mouse  1029 EQQVDDLESSLEQEKKLRVDLERNKRKLEGDL 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	241/719 (34%)
		MYSc_Myo1	21..677	CDD:276829	236/694 (34%)
		Myosin_TH1	801..983	CDD:283635	32/201 (16%)
Myh3	NP_001093105.1	Myosin_N	35..73	CDD:367160
		MYSc_Myh3	100..767	CDD:276878	236/694 (34%)
		Actin-binding. /evidence=ECO:0000250	656..678		8/21 (38%)
		Actin-binding. /evidence=ECO:0000250	758..772		6/14 (43%)
		Myosin_tail_1	847..1924	CDD:366712	51/280 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1260..1289
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000