DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo31DF and Myh11

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	XP_006521906.1	Gene:	Myh11 / 17880	MGIID:	102643	Length:	1979	Species:	Mus musculus

Alignment Length:	801	Identity:	289/801 - (36%)
Similarity:	445/801 - (55%)	Gaps:	71/801 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73
            |:|...|..::....:.|||:|:.:|.||||.|..||.:|||:.:.||..:.:..|||::..|..
Mouse    87 VEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKYLPIYSEKIVDMYKGKKRHEMP 151

  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNA----------QGQN- 127
            ||::||||:|||.:.|.::|..||.:|||||||||.:|.:::|:|.|.::          ||.:
Mouse   152 PHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDSSITQGPSF 216

  Fly   128 ---EIERVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRV 189
               |:|:   .|:|:|.|||.||||||.:|||||||||::.|.||.....||..|..|||||||.
Mouse   217 AYGELEK---QLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRA 278

  Fly   190 VQQQPGERNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQGSMDILTEKSD--YKGTCNAFKT 252
            ::|...||.||.||.||.||.: :::...|.:....|.:|:.|.:.|...:.|  ::.|..|...
Mouse   279 IRQARDERTFHIFYYLLAGAKE-KMKSDLLLESFNSYTFLSNGFVPIPAAQDDEMFQETLEAMSI 342

  Fly   253 LGFSTDEVQTIWRTIAAVLHLGNVEF--QTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRV 315
            :||:.:|...|.:.:::||.|||:.|  :...|:..:.:....:....|:.:..|:.:.|:....
Mouse   343 MGFNEEEQLAILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLVGINVTDFTRAILTPR 407

  Fly   316 IAAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIY 380
            |..|.:|:||.....||::..:|||||.|:|||.||:||:|:|:    .||..:..|.:|:|||.
Mouse   408 IKVGRDVVQKAQTKEQADFAIEALAKATYERLFRWILSRVNKAL----DKTHRQGASFLGILDIA 468

  Fly   381 GFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIIC-DLVEQPH 444
            |||||:.|||||.||||.||||||||...:...||||||||||||..|::..:...| :|:|:|:
Mouse   469 GFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPN 533

  Fly   445 K--GIIAIMDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDV 507
            .  |::|::||.|. ..|.||.:.:..:......||.:.    ||  |:||.:.:|.|.||||.|
Mouse   534 NPPGVLALLDEECW-FPKATDKSFVEKLCSEQGNHPKFQ----KP--KQLKDKTEFSIIHYAGKV 591

  Fly   508 IYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPE-----GAQDIKKTTKRPL---------- 557
            .||.:.::.||.|.|..:...||:.|.|..::::|.:     |...:.|.|:..|
Mouse   592 DYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGM 656

  Fly   558 --TAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAG 620
              |.|.|::..:..|:.||....|.:||||.||..|.|...|...|..|:|..|:||.:|:.|.|
Mouse   657 FRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQG 721

  Fly   621 FVHRQRYDKFLLRYKMISQYTWP-NFRAGSDRDGVRVLIEEKKFAQDV-KYGHTKIFIRSPRTLF 683
            |.:|..:.:|..||::::....| .|..|  :....::|:..:...:: :.|.:|||.|: ..|.
Mouse   722 FPNRIVFQEFRQRYEILAANAIPKGFMDG--KQACILMIKALELDPNLYRIGQSKIFFRT-GVLA 783

  Fly   684 ALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMKAAIT----IVRAYKAY-KLRSY--------V 735
            .||.:|:..|..::...|...||::.|:.|.|.:..:|    |.|...|| |||::        |
Mouse   784 HLEEERDLKITDVIMAFQAMCRGYLARKAFTKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKV 848

  Fly   736 QELANRLRKAKQMRDYGKSIQ 756
            :.|....|:.::|:...:.:|
Mouse   849 KPLLQVTRQEEEMQAKEEEMQ 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	268/720 (37%)
		MYSc_Myo1	21..677	CDD:276829	261/695 (38%)
		Myosin_TH1	801..983	CDD:283635
Myh11	XP_006521906.1	Myosin_N	33..71	CDD:367160
		MYSc_class_II	99..778	CDD:276951	261/695 (38%)
		Myosin_tail_1	855..1935	CDD:366712	3/15 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000