Protein Alignment Myo31DF and hum-1

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: NP_492393.1
• Gene: hum-1 / 172698
• WormBaseID: WBGene00002035
• Length: 1100
• Species: Caenorhabditis elegans
• Alignment Length: 1002
• Identity: 349/1002 - (34%)
• Similarity: 518/1002 - (51%)
• Gaps: 182/1002 - (18%)

  Fly     5 REAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGREL 69
            :..||.|.|||.:::.:..::||:||.|..||:||||.|.:|:||::||..:..:.:..|:|...
 Worm    12 QHVGVDDMVLLPKLTEQSIVENLKKRLQANSIFTYIGPVLISVNPFKQMPYFTEKEMLLYQGAAQ 76

  Fly    70 FENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKN 134
            :|||||::|:||:.||.:....:..|::||||||||||..:|.||.||:.::.  |..:::.:|:
 Worm    77 YENAPHIYALADNMYRNMLIDNESQCVIISGESGAGKTVNAKFIMNYISRISG--GGQKVQHIKD 139

  Fly   135 VLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNF 199
            |::|||.:||.|||:.|.||.||||||||::|.|....:|:||.::|:||||||||.|..|:|||
 Worm   140 VILQSNPLLEAFGNSATVRNWNSSRFGKYVEIVFSRGGEPIGGKLSNFLLEKSRVVHQNEGDRNF 204

  Fly   200 HSFYQLLRGANDNELRQY----ELQKETGKYHYLNQGSM---DILTEKSDYKGTCNAFKTLGFST 257
            |.||||..|| |..||..    |||    .|:|||...:   |...:..:::.|.:|.|.:|.:.
 Worm   205 HVFYQLCAGA-DKNLRSTFGIGELQ----YYNYLNMSGVFKADDTDDGKEFESTLHAMKVVGVND 264

  Fly   258 DEVQTIWRTIAAVLHLGNVEFQTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNV 322
            .:...:.|.:|.|||:||:.|....:...:|.|.:|:..|.||.:|..::...||.|.:.:....
 Worm   265 QDQLEVLRIVATVLHIGNITFTEENNFAAVSGKDYLEYPAFLLGLTSADIEAKLTGRKMESKWGT 329

  Fly   323 MQKDH-----NATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGF 382
             ||:.     |..||.|.:||..||||.|||.:::.::|.|:......|...|:  :|:||||||
 Worm   330 -QKEEIDMKLNVEQASYTRDAWVKAIYARLFDYLVKKVNDAMNITSQSTSDNFS--VGILDIYGF 391

  Fly   383 EIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPH-KG 446
            |||::|.|||||||:.||||||:||||.||.|||||.||||:||.|:||:|||:|||:|... .|
 Worm   392 EIFNNNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVREGIKWTEIDYFDNKIVCDLIETKRPPG 456

  Fly   447 IIAIMDEACL---SVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVI 508
            |::::|:.|.   ...:..|..||..:.|:.:.|||:....           :.|.|.||||||.
 Worm   457 IMSLLDDTCAQNHGQREGVDRQLLTTLSKSFAGHPHFGPGS-----------DSFVIKHYAGDVT 510

  Fly   509 YNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVT 573
            ||::||.::|:|.||.|...|:..|....:..::||..  .....|||.|..|..:.....||.:
 Worm   511 YNVDGFCDRNRDVLYPDLILLMQKSSRPFIQALFPENV--AASAGKRPTTFSTKIRTQANTLVES 573

  Fly   574 LLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMIS 638
            |:|..|.||||||||:.|....::|.||:|||.||||.||:|||||||.:|:.:|||..||.::|
 Worm   574 LMKCSPHYVRCIKPNETKRPNDWEESRVKHQVEYLGLRENIRVRRAGFAYRRAFDKFAQRYAIVS 638

  Fly   639 QYTWPNFRAGSDR------DGVRVLIEEKKFAQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIV 697
            ..|||.|:....|      |.|.  :|:.::    :.|.||||:::|.:||.||..|........
 Worm   639 PQTWPCFQGDQQRACEIICDSVH--MEKNQY----QMGKTKIFVKNPESLFLLEETRERKFDGYA 697

  Fly   698 TLLQKRVRGWIVRRNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQMRDYGKSIQWPQPPL 762
            .::||..|.:..|:...|.|                  ::.|:.:...|:.|.|..:
 Worm   698 RVIQKAWRQFSARKQHIKQK------------------EQAADLMYGKKERRRYSLN-------- 736

  Fly   763 AGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQ 827
                                                                 |.:||||:
 Worm   737 -----------------------------------------------------RNFVGDYI---- 744

  Fly   828 ENSGYEAYNGSIKNIRNHPA----DGETFQQVLFSSFVKKFNHFNKQANRAFIVSD----STIHK 884
                         .:.:||.    .|:. |:|||:....|:       :|.|.|:.    .|::.
 Worm   745 -------------GLEHHPTLQSLVGKR-QRVLFACTANKY-------DRKFRVTKLDLLLTVNH 788

  Fly   885 LDGI-KNKFKD----------MKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFSLESEYTPL 938
            |..| |.|.|:          :||...:.::.||.:||.:|..::.:.. |.|....||   ||.
 Worm   789 LTLIGKEKVKNGPEKGKIVEVIKRQFDLPQIKSIGLSPYQDDFVILYLG-NDDYSSLLE---TPF 849

  Fly   939 KEDRIGEVVGIVCKKYHDLTGTELRVN 965
            |.    |....:.|.|.:.|...|.::
 Worm   850 KT----EFCTALSKAYKERTNGTLHLD 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	286/677 (42%)
		Myosin_TH1	801..977	CDD:461801	41/184 (22%)
hum-1	NP_492393.1	MYSc	9..690	CDD:214580	297/706 (42%)
		Myosin_TH1	717..920	CDD:461801	46/268 (17%)
		SH3	1051..1100	CDD:473055