DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo31DF and hum-1

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_492393.1	Gene:	hum-1 / 172698	WormBaseID:	WBGene00002035	Length:	1100	Species:	Caenorhabditis elegans

Alignment Length:	1002	Identity:	349/1002 - (34%)
Similarity:	518/1002 - (51%)	Gaps:	182/1002 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 REAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGREL 69
            :..||.|.|||.:::.:..::||:||.|..||:||||.|.:|:||::||..:..:.:..|:|...
Worm    12 QHVGVDDMVLLPKLTEQSIVENLKKRLQANSIFTYIGPVLISVNPFKQMPYFTEKEMLLYQGAAQ 76

  Fly    70 FENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKN 134
            :|||||::|:||:.||.:....:..|::||||||||||..:|.||.||:.::.  |..:::.:|:
Worm    77 YENAPHIYALADNMYRNMLIDNESQCVIISGESGAGKTVNAKFIMNYISRISG--GGQKVQHIKD 139

  Fly   135 VLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNF 199
            |::|||.:||.|||:.|.||.||||||||::|.|....:|:||.::|:||||||||.|..|:|||
Worm   140 VILQSNPLLEAFGNSATVRNWNSSRFGKYVEIVFSRGGEPIGGKLSNFLLEKSRVVHQNEGDRNF 204

  Fly   200 HSFYQLLRGANDNELRQY----ELQKETGKYHYLNQGSM---DILTEKSDYKGTCNAFKTLGFST 257
            |.||||..|| |..||..    |||    .|:|||...:   |...:..:::.|.:|.|.:|.:.
Worm   205 HVFYQLCAGA-DKNLRSTFGIGELQ----YYNYLNMSGVFKADDTDDGKEFESTLHAMKVVGVND 264

  Fly   258 DEVQTIWRTIAAVLHLGNVEFQTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNV 322
            .:...:.|.:|.|||:||:.|....:...:|.|.:|:..|.||.:|..::...||.|.:.:....
Worm   265 QDQLEVLRIVATVLHIGNITFTEENNFAAVSGKDYLEYPAFLLGLTSADIEAKLTGRKMESKWGT 329

  Fly   323 MQKDH-----NATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGF 382
             ||:.     |..||.|.:||..||||.|||.:::.::|.|:......|...|:  :|:||||||
Worm   330 -QKEEIDMKLNVEQASYTRDAWVKAIYARLFDYLVKKVNDAMNITSQSTSDNFS--VGILDIYGF 391

  Fly   383 EIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPH-KG 446
            |||::|.|||||||:.||||||:||||.||.|||||.||||:||.|:||:|||:|||:|... .|
Worm   392 EIFNNNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVREGIKWTEIDYFDNKIVCDLIETKRPPG 456

  Fly   447 IIAIMDEACL---SVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVI 508
            |::::|:.|.   ...:..|..||..:.|:.:.|||:....           :.|.|.||||||.
Worm   457 IMSLLDDTCAQNHGQREGVDRQLLTTLSKSFAGHPHFGPGS-----------DSFVIKHYAGDVT 510

  Fly   509 YNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVT 573
            ||::||.::|:|.||.|...|:..|....:..::||..  .....|||.|..|..:.....||.:
Worm   511 YNVDGFCDRNRDVLYPDLILLMQKSSRPFIQALFPENV--AASAGKRPTTFSTKIRTQANTLVES 573

  Fly   574 LLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMIS 638
            |:|..|.||||||||:.|....::|.||:|||.||||.||:|||||||.:|:.:|||..||.::|
Worm   574 LMKCSPHYVRCIKPNETKRPNDWEESRVKHQVEYLGLRENIRVRRAGFAYRRAFDKFAQRYAIVS 638

  Fly   639 QYTWPNFRAGSDR------DGVRVLIEEKKFAQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIV 697
            ..|||.|:....|      |.|.  :|:.::    :.|.||||:::|.:||.||..|........
Worm   639 PQTWPCFQGDQQRACEIICDSVH--MEKNQY----QMGKTKIFVKNPESLFLLEETRERKFDGYA 697

  Fly   698 TLLQKRVRGWIVRRNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQMRDYGKSIQWPQPPL 762
            .::||..|.:..|:...|.|                  ::.|:.:...|:.|.|..:
Worm   698 RVIQKAWRQFSARKQHIKQK------------------EQAADLMYGKKERRRYSLN-------- 736

  Fly   763 AGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQ 827
                                                                 |.:||||:
Worm   737 -----------------------------------------------------RNFVGDYI---- 744

  Fly   828 ENSGYEAYNGSIKNIRNHPA----DGETFQQVLFSSFVKKFNHFNKQANRAFIVSD----STIHK 884
                         .:.:||.    .|:. |:|||:....|:       :|.|.|:.    .|::.
Worm   745 -------------GLEHHPTLQSLVGKR-QRVLFACTANKY-------DRKFRVTKLDLLLTVNH 788

  Fly   885 LDGI-KNKFKD----------MKRTIKIRELTSISVSPGRDQLIVFHSSKNKDLVFSLESEYTPL 938
            |..| |.|.|:          :||...:.::.||.:||.:|..::.:.. |.|....||   ||.
Worm   789 LTLIGKEKVKNGPEKGKIVEVIKRQFDLPQIKSIGLSPYQDDFVILYLG-NDDYSSLLE---TPF 849

  Fly   939 KEDRIGEVVGIVCKKYHDLTGTELRVN 965
            |.    |....:.|.|.:.|...|.::
Worm   850 KT----EFCTALSKAYKERTNGTLHLD 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	297/705 (42%)
		MYSc_Myo1	21..677	CDD:276829	286/677 (42%)
		Myosin_TH1	801..983	CDD:283635	41/184 (22%)
hum-1	NP_492393.1	MYSc	9..690	CDD:214580	297/706 (42%)
		MYSc_Myo1	28..677	CDD:276829	286/677 (42%)
		Myosin_TH1	717..902	CDD:283635	46/268 (17%)
		Rubella_Capsid	906..>1003	CDD:283420
		SH3	1051..1100	CDD:302595
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2201
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850