DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and spe-15

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_490856.1	Gene:	spe-15 / 171712	WormBaseID:	WBGene00004969	Length:	1219	Species:	Caenorhabditis elegans

Alignment Length:	959	Identity:	286/959 - (29%)
Similarity:	461/959 - (48%)	Gaps:	147/959 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EAGVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMN-IYGPETIRKYKGREL 69
            :..|:|...|..::....::|.|.|:.||.||||:..:.:|:|||:.:: :|.||||::|:|:.|
Worm    63 QKSVEDNCALVHLNEATLLNNCRLRYANGKIYTYVANILISINPYQLIDGLYSPETIKEYRGKSL 127

  Fly    70 FENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQN---EIER 131
            .:..||:|||||.|||.:::.:....|::||||||||||:.|.::||:.       :|   :...
Worm   128 GQMEPHIFAIADKAYREMRRIKTSQSIIVSGESGAGKTESQKAVLKYLC-------ENWGTDAGP 185

  Fly   132 VKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGE 196
            ::..|:::|.|||.||||||.||:|||||||::.|.|.......||.:::||||.|||.:|..||
Worm   186 IQQRLLETNPILEAFGNAKTLRNNNSSRFGKFVQIHFSDNGTVAGGFVSHYLLETSRVCRQAAGE 250

  Fly   197 RNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQG--------------------------SMD 235
            ||:|.||||:.|::.:..::..| .....::||..|                          |..
Worm   251 RNYHIFYQLIAGSSPDLYKKLRL-APASSFNYLKHGATLFFVNSKSSLKTDASRFSETNSSVSDS 314

  Fly   236 ILTEKSDYKGTCNAFKTLGFSTDEVQTIWRTIAAVLHLGNVEFQTIEDE-----LVISNKQH-LK 294
            |:::..|:.....|....|.|.||...||.|:|.:|||||:||:....:     ::.|..:: |.
Worm   315 IISDIDDFAKLERALALSGVSDDEKMFIWSTVAGILHLGNIEFEENASDSRGGCMITSGTENSLM 379

  Fly   295 STAKLLQVTETELSTALTKRVI-----AAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISR 354
            :.|:||.:...|:...|..|::     ...|.:::....|.:|..|:||||||||.:||.|::::
Worm   380 AAAELLGLEPEEMKLGLCARIMQTTKGGVKGTLIRVPLKAHEASAGRDALAKAIYSKLFDWLVAQ 444

  Fly   355 INRAILFRGSKTQARFNSVIGVLDIYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQ 419
            ||::|.|..|      ...|||||:.|||.|..|||||||||:||||||..|.|.:||||||.|:
Worm   445 INKSIPFEKS------TGYIGVLDVAGFEYFAVNSFEQFCINFCNEKLQHFFNERILKQEQEMYE 503

  Fly   420 REGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQ 484
            .||:....||:.:|....:|.|:...|:..::||         :..|..|..::.::..|.:::.
Worm   504 AEGLNIQKIEFTDNLDCIELFEKKASGLFDLLDE---------EAKLPRATFQHFTQRAHESNKN 559

  Fly   485 LKPTD----------KELKHREDFRITHYAGDVIYNINGFIEKNKDTLYQDFKRLLHNSKDANLS 539
            ....|          :|::..|...|.||||.|.|....|:|||.|.|:...:.|:..|....:.
Worm   560 HFRLDAPRKSKVKSHREMRDDEGLLIRHYAGTVCYETRYFVEKNNDQLHNSLEMLIEQSSFPLVV 624

  Fly   540 EMWPEGAQDIKKTTKR--PLTAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVE 602
            .::...|....||..|  .::.|..|:..::.|:..|......:|||:|||....:..||...:.
Worm   625 SLFTSEATGAVKTGGRLKAVSVGAKFKSQLSSLLDKLNNTGTHFVRCVKPNSQMKAWHFDGSAIL 689

  Fly   603 HQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAGSDRDGVRVLIEEKKFAQ-D 666
            .|::..|:...||:.:.||..|   ..|...|.|..:...|:......|...:.|.......| |
Worm   690 GQLQCAGMASVLRLMQEGFPSR---TSFADLYAMYEKNLPPSLARLDPRLFSKCLFHALGLDQND 751

  Fly   667 VKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMKAAITIVRAYKAYKL 731
            .::|:||:|..:.:  ||...|..:..|..|..|..:|..|:|:..::|::..     |:...||
Worm   752 FQFGNTKVFFTAGK--FAEFDQMMKQDPETVMELISKVTDWLVKARWRKVQYG-----AWSVIKL 809

  Fly   732 RSYVQELANRLRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRSEWPQLR 796
            ::.:...|.:::|.:         .|    :.|..|..:.|:....:|
Worm   810 KNKILYRAEKIKKIQ---------AW----IRGYLVRKRFHKRLAIFR----------------- 844

  Fly   797 LQIIAATALAGRRPYWGQARRWVGDYLANSQENSGYEA-YNGSIKNIRNHPADGETFQQVLFSSF 860
                .|.||                 |.||:|.:...| .|.|.::.....||..|.:   ....
Worm   845 ----KACAL-----------------LENSREMTDILARMNESSQDKWREAADSTTGE---LDEL 885

  Fly   861 VK--KFNHFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSI 907
            ||  |.:..|.:.:||....:..:.::|.|   ..|:|..::..||..:
Worm   886 VKTIKNDDLNTEIDRAVKCYEDCVKRVDSI---IADLKLQLENDELAEV 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	244/737 (33%)
		MYSc_Myo1	21..677	CDD:276829	238/709 (34%)
		Myosin_TH1	801..983	CDD:283635	25/110 (23%)
spe-15	NP_490856.1	Myosin_N	12..49	CDD:367160
		MYSc_Myo6	78..761	CDD:276833	237/708 (33%)
		IQ	<820..837	CDD:197470	4/29 (14%)
		MAP7	<929..>1000	CDD:368554	0/3 (0%)
		Myosin-VI_CBD	1123..1211	CDD:374599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920