DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo31DF and Myh7

DIOPT Version :9

Sequence 1:	NP_001188784.1	Gene:	Myo31DF / 34445	FlyBaseID:	FBgn0086347	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001348536.1	Gene:	Myh7 / 140781	MGIID:	2155600	Length:	1935	Species:	Mus musculus

Alignment Length:	1063	Identity:	312/1063 - (29%)
Similarity:	505/1063 - (47%)	Gaps:	160/1063 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENA 73
            ::|..:|..:.....:.||::|:.:..||||.|..||::|||:.:.:|..|.:..|:|::..|..
Mouse    87 IEDMAMLTFLHEPAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAP 151

  Fly    74 PHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVT---------NAQGQNEI 129
            ||:|:|:|:||:.:...:::..|||:||||||||..:|.:::|.|.:.         ...|:..:
Mouse   152 PHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTL 216

  Fly   130 ERVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQP 194
            |   :.:||:|..||.||||||.||||||||||::.|.|..........|..||||||||:.|..
Mouse   217 E---DQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLK 278

  Fly   195 GERNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQGSMDI--LTEKSDYKGTCNAFKTLGFST 257
            .||::|.|||:|.......|....:......|.:::||...:  :.:..:...|.:||..|||:.
Mouse   279 AERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDSEELMATDSAFDVLGFTP 343

  Fly   258 DEVQTIWRTIAAVLHLGNVEF--QTIEDELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGG 320
            :|..:|::...|::|.||::|  :..|::......:....:|.|:.:...:|...|....:..|.
Mouse   344 EEKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGN 408

  Fly   321 NVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIF 385
            ..:.|..|..|..|...||||::|:::|.|:::|||..:     :|:......||||||.|||||
Mouse   409 EYVTKGQNVQQVSYAIGALAKSVYEKMFNWMVTRINATL-----ETKQPRQYFIGVLDIAGFEIF 468

  Fly   386 DSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIIC-DLVEQPHKGIIA 449
            |.|||||.|||:.||||||.|...:...|||||::||||||.|::..:...| ||:|:| .||::
Mouse   469 DFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKP-MGIMS 532

  Fly   450 IMDEACLSVGKVTDDTLLGAM-DKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNING 513
            |::|.|: ..|.||.|....: |.:|.|..::.    ||.:.:.|....|.:.||||.|.|||.|
Mouse   533 ILEEECM-FPKATDMTFKAKLYDNHLGKSNNFQ----KPRNVKGKQEAHFSLVHYAGTVDYNILG 592

  Fly   514 FIEKNKDTLYQDFKRLLHNSKDANLSEMW----------PEGAQDIKKTTKRPLTAGTLFQRSMA 568
            :::||||.|.:....|...|....||.::          .:|....||.:... |...|.:.::.
Mouse   593 WLQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPADKGKGKAKKGSSFQ-TVSALHRENLN 656

  Fly   569 DLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLR 633
            .|:..|....|.:||||.||:.||..|.|...|.||:|..|:||.:|:.|.||.:|..|..|..|
Mouse   657 KLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQR 721

  Fly   634 YKMISQYTWPNFRAGSDRDGVRVL-----IEEKKFAQDVKYGHTKIFIRSPRTLFALEHQRNEMI 693
            |::::....|..:....|.|...|     |:..::    |:||||:|.:: ..|..||..|:|.:
Mouse   722 YRILNPAAIPEGQFIDSRKGAEKLLGSLDIDHNQY----KFGHTKVFFKA-GLLGLLEEMRDERL 781

  Fly   694 PHIVTLLQKRVRGWIVRRNFKKM---KAAITI----VRAYKA----------YKLRSYVQELANR 741
            ..|:|.:|.:.||.:.|..|||:   :.::.|    :||:..          :|::..::.....
Mouse   782 SRIITRIQAQSRGVLSRMEFKKLLERRDSLLIIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETE 846

  Fly   742 LRKAKQMRDYGKSIQWPQPPLAGRK-VEAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATAL 805
            ...|....::|:.....:...|.|| :|.|:..:.              .|...|:||:
Mouse   847 KEMATMKEEFGRVKDALEKSEARRKELEEKMVSLL--------------QEKNDLQLQV------ 891

  Fly   806 AGRRPYWGQARRWVGDYLANSQENSGYEAYN-----GSIKNIRNHPADGETFQQVLFSSFVKKFN 865
                    ||.:   |.||:::|.......|     ..:|.:.....|.|.....|.:
Mouse   892 --------QAEQ---DNLADAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTA------- 938

  Fly   866 HFNKQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIVFHSSKNK----- 925
                              |...::::..::||.|...|||...|...:      |:::||
Mouse   939 ------------------KKRKLEDECSELKRDIDDLELTLAKVEKEK------HATENKVKNLT 979

  Fly   926 -------DLVFSLESEYTPLKEDRIGEVVGIVCKKYHDLTGTELRVNVTTNISCRLDGKARII-- 981
                   :::..|..|...|:|..        .:...||...|.:||..|....:|:.:...:
Mouse   980 EEMAGLDEIIVKLTKEKKALQEAH--------QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEG 1036

  Fly   982 TVEAASNVEVPNFRPK---EGNI 1001
            ::|....|.:...|.|   ||::
Mouse  1037 SLEQEKKVRMDLERAKRKLEGDL 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_001188784.1	MYSc	6..690	CDD:214580	247/710 (35%)
		MYSc_Myo1	21..677	CDD:276829	242/685 (35%)
		Myosin_TH1	801..983	CDD:283635	33/200 (17%)
Myh7	NP_001348536.1	COG5022	37..1432	CDD:227355	312/1063 (29%)
		MYSc_class_II	99..766	CDD:276951	242/685 (35%)
		Actin-binding	655..677		8/21 (38%)
		Actin-binding	757..771		6/14 (43%)
		SMC_prok_B	1173..1930	CDD:274008
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1915..1935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000