DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cog4 and cog4

DIOPT Version :9

Sequence 1:	NP_609413.1	Gene:	Cog4 / 34442	FlyBaseID:	FBgn0032258	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001034912.1	Gene:	cog4 / 569049	ZFINID:	ZDB-GENE-060312-33	Length:	781	Species:	Danio rerio

Alignment Length:	778	Identity:	300/778 - (38%)
Similarity:	474/778 - (60%)	Gaps:	45/778 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EQVDETLQRIADEEAKVNEKLESLLAKQCQIEAKMSGIGRSLSLLHTVDSDSNKLNDQIVNTAQL 80
            |.::....::..|||:|..:|::|:.:|..||.||..:.|....|..::.|:.:|:..|..|..|
Zfish    32 EDLERVYAQLCAEEAEVQVELDALVGQQNNIETKMLSLQRMGPNLQLIEGDAVQLSGMINFTCSL 96

  Fly    81 AESVSAKVRRLDLARCRASECQQRVHDLIDLHLCSQGVVKAIGEEDYEKSATHIARFLAMDQQLL 145
            ||:||:|||:|||.:.|..:..||..|::||..|:.||..|:..:|||::|.||.|:|::||.::
Zfish    97 AENVSSKVRQLDLTKKRLYQAIQRADDILDLKFCTDGVQTALRNQDYEQAAAHIHRYLSLDQSVI 161

  Fly   146 RRTADDVQGSITSVSDAVKTLEDATEKTRVLIAKRFDEAVKADDLASVERFFKIFPLVGCHRTGI 210
            ..:....:||....|.|:  |::|....:.|:..|.:|||...||..|||||||.||:|.|..|:
Zfish   162 ELSKQGGEGSAVEASLAL--LQEAERNLKTLVTTRLEEAVATGDLPQVERFFKILPLLGLHEQGL 224

  Fly   211 EKFSLYICQKLANKAQKELRNAQDIAKAESRLQLAYADRLTAILENFARVVEVNQPIIEAFYGQA 275
            .:|:.|:|.:||:||::.|..|......|.|..:.:||.||.:||..||:||.:|||:|.:||
Zfish   225 ARFAQYLCSQLASKAEENLILAVGSDLGERRAPVIFADTLTLLLEGIARIVETHQPIVETYYG-- 287

  Fly   276 SSSLIDMVSILQHECDTEVKNLLMEFNKNRQIQYRSKQVNESTQRSAGGGNLGSNSIQALGHYRK 340
            ...|..:::.||.|||.:.:.::.:|.:.|....:.:.|..:..|
Zfish   288 PGRLHTLLAHLQKECDKQAQKIVDKFIQQRDYNNKFQVVQSNMMR-------------------- 332

  Fly   341 PSGGSVDKLNPKEIDAIIAEITVMHARVELYFRFMRRRLQVHVETCVPEKEQFDIMER---YEKI 402
              |.:.||:.|:::|.::.|:|:|::|.||||||:|||:....|......::..|.|.   .|::
Zfish   333 --GMTTDKIEPRDLDPVLCEVTLMNSRAELYFRFLRRRIVADFEVADAMADEAVIQEHQQSLEQL 395

  Fly   403 MKNSDLRRQMQEILSTYLLLERYFMEESVLKAIGLDTYESGQQCSSMVDDVFFILRKSIRRALTT 467
            :||..|.|.|||::..|:.:|.|:|.|||.||:.:||.|.||..||:|||||:|::|.|.||||:
Zfish   396 LKNCQLSRTMQELIGYYIPMEEYYMRESVNKAVAMDTAEVGQLSSSVVDDVFYIVKKCISRALTS 460

  Fly   468 QSINGTCAVINNVAACLDGDFVNALKAPLKSGYP-SGYIDL----AQAYNAIQTSLQQGKLHS-- 525
            .|.:..||:||:..:.|:.||...|...|::||| |...||    :.|.:.:|:||||||:.:
Zfish   461 SSSDCVCAMINHATSVLETDFREVLVCKLRAGYPVSALQDLQRGVSSAVSLMQSSLQQGKITNLT 525

  Fly   526 -----SDADRGRANFLVQLNNADISTEYIETLCQTMEQEIAGTFPQ--TTQVERQMLDSCLTELK 583
                 ...::.::.:||.|||.::.:|.|.||.:.:|.:.|..|.|  ::...::.:||||::|.
Zfish   526 QTLGIESQEQAKSAYLVTLNNVEVCSENISTLKKNLESDCAKLFSQGASSDHAKEKIDSCLSDLV 590

  Fly   584 AVRDALKATVDFGMQQLRSSVIKPRLNPWINQFLNYSHNLNEEELAAYEAGETFVQFFIVQLDGL 648
            ......|..:..|:|:|.::.|:|::.|||:.||:.|||:.|||.:.|||.:.|||..||||:.|
Zfish   591 NTSSKFKDLLQEGLQELNNTAIRPQVKPWISSFLSVSHNIEEEEFSEYEANDPFVQQLIVQLEQL 655

  Fly   649 LNSFKNSLSPRNYDALVSILATEVTIQLERAIKKISFNRLGGLVLDQEVRALGSYLTGATSWSVR 713
            :..||..|||..||.|.|::.:.:.:::|:.:.|.:|:|||||..|:|:|||.:||:..|||::|
Zfish   656 MAEFKVGLSPVIYDTLTSLMTSLIAMEMEKTVFKCTFSRLGGLQFDKELRALVAYLSSVTSWTIR 720

  Fly   714 DKMTRISQIATLLNLDKITELSEYWNPENNKEMSSWHLTPNEVRTFLTLRNDFRIEDIKRLQL 776
            ||..|::|:||:|||::::|:.:||.|  |....:|.|||.|||..|.||.|||.||||||:|
Zfish   721 DKFARLTQMATILNLERVSEILDYWGP--NSGPLTWRLTPAEVRQVLALRVDFRSEDIKRLRL 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cog4	NP_609413.1	Cog4	166..497	CDD:214809	124/333 (37%)
cog4	NP_001034912.1	COG4	180..489	CDD:369812	124/332 (37%)
		D domain. /evidence=ECO:0000250\|UniProtKB:Q9H9E3	614..736		59/121 (49%)
		E domain, essential for proper cell surface glycosylation. /evidence=ECO:0000250\|UniProtKB:Q9H9E3	737..781		24/45 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581981
Domainoid	1	1.000	235	1.000	Domainoid score	I2307
eggNOG	1	0.900	-	-		E1_KOG0412
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7155
Inparanoid	1	1.050	549	1.000	Inparanoid score	I1112
OMA	1	1.010	-	-		QHG54204
OrthoDB	1	1.010	-	-		D139188at33208
OrthoFinder	1	1.000	-	-		FOG0004935
OrthoInspector	1	1.000	-	-		oto39550
orthoMCL	1	0.900	-	-		OOG6_102876
Panther	1	1.100	-	-	LDO	PTHR24016
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R221
SonicParanoid	1	1.000	-	-		X4025
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800