Protein Alignment Cog4 and Cog4

DIOPT Version :9

• Sequence 1: NP_609413.1
• Gene: Cog4 / 34442
• FlyBaseID: FBgn0032258
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001101919.1
• Gene: Cog4 / 361407
• RGDID: 1310549
• Length: 785
• Species: Rattus norvegicus
• Alignment Length: 776
• Identity: 304/776 - (39%)
• Similarity: 474/776 - (61%)
• Gaps: 45/776 - (5%)

  Fly    16 EQVDETLQRIADEEAKVNEKLESLLAKQCQIEAKMSGIGRSLSLLHTVDSDSNKLNDQIVNTAQL 80
            ::::...:|:..||..|.::|::||.:|..||:||..:.|....|..::.|:.:|...|..|..|
  Rat    40 QELEAVYERLCGEEKVVEKELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNL 104

  Fly    81 AESVSAKVRRLDLARCRASECQQRVHDLIDLHLCSQGVVKAIGEEDYEKSATHIARFLAMDQQLL 145
            ||:||:|||:||||:.|..:..||..|::||..|..||..|:..||||::|.||.|:|.:|:.::
  Rat   105 AENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHIHRYLCLDKSVI 169

  Fly   146 RRTADDVQGSITSVSDAVKTLEDATEKTRVLIAKRFDEAVKADDLASVERFFKIFPLVGCHRTGI 210
            ..:....:||:...:  :|.|::|.::.:.::|::|..|.|..||..||||||||||:|.|..|:
  Rat   170 ELSRQGKEGSMIDAN--LKLLQEAEQRLKAIVAEKFAAATKEGDLPQVERFFKIFPLLGLHEDGL 232

  Fly   211 EKFSLYICQKLANKAQKELRNAQDIAKAESRLQLAYADRLTAILENFARVVEVNQPIIEAFYGQA 275
            .|||.|:|:::|:||::.|........::.|..:.:||.||.:.|..||:||.:|||:|.:||
  Rat   233 SKFSEYLCKQVASKAEENLLLVLGSDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYG-- 295

  Fly   276 SSSLIDMVSILQHECDTEVKNLLMEFNKNRQI--QYRSKQVNESTQRSAGGGNLGSNSIQALGHY 338
            ...|..::..||.||||:|:.::.:|.|.|..  |:|..|           .||..||
  Rat   296 PGRLFTLIKYLQVECDTQVEKVVNKFIKQRDYHQQFRLVQ-----------SNLMRNS------- 342

  Fly   339 RKPSGGSVDKLNPKEIDAIIAEITVMHARVELYFRFMRRRLQVHVE---TCVPEKEQFDIMERYE 400
                  :.:|:.|:|:|.::.|:|:|:||.|||.||:|:|:....|   :...|:.:.:..:..:
  Rat   343 ------ATEKIEPRELDPVLTEVTLMNARSELYLRFLRKRISADFEVGDSMASEEVKQEHQKCLD 401

  Fly   401 KIMKNSDLRRQMQEILSTYLLLERYFMEESVLKAIGLDTYESGQQCSSMVDDVFFILRKSIRRAL 465
            |::.|..|...|||::..|:.:|.|||.|:|.||:.|||||.||..||||||||:|::|.|.|||
  Rat   402 KLLNNCLLSCTMQELVGFYITMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRAL 466

  Fly   466 TTQSINGTCAVINNVAACLDGDFVNALKAPLKSGYPSGYID-----LAQAYNAIQTSLQQGKLHS 525
            ::.:|:..||:||.....|:.||.:.|...|:.|:|:..:.     :..|.|.:.:||||||..:
  Rat   467 SSSNIDCLCAMINLATRELEADFRDVLCNKLRMGFPATTLQDIQRGVTSAVNIMHSSLQQGKFDT 531

  Fly   526 ---SDADRGRANFLVQLNNADISTEYIETLCQTMEQEIAGTFPQTTQVERQM--LDSCLTELKAV 585
               ...|..:.:|||.|||.::.:|.|.||.:|:|.:....|.|....|:..  .||||::|.||
  Rat   532 KGIESTDEAKLSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAV 596

  Fly   586 RDALKATVDFGMQQLRSSVIKPRLNPWINQFLNYSHNLNEEELAAYEAGETFVQFFIVQLDGLLN 650
            .:..:..:..|:.:|.||.:||::.||||.||:.||::.|||...|||.:.:||.||:.|:..:.
  Rat   597 SNKFRDLLQEGLAELNSSAVKPQVQPWINTFLSVSHSIEEEEFNDYEANDPWVQQFILSLEQQMA 661

  Fly   651 SFKNSLSPRNYDALVSILATEVTIQLERAIKKISFNRLGGLVLDQEVRALGSYLTGATSWSVRDK 715
            .||.||||..||:|..::.:.|.::||:.:.|.:|||||||..|:|:|:|.:|||..|:|::|||
  Rat   662 EFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDK 726

  Fly   716 MTRISQIATLLNLDKITELSEYWNPENNKEMSSWHLTPNEVRTFLTLRNDFRIEDIKRLQL 776
            ..|:||:||:|||:::||:.:||..  |....:|.|||.|||..|.||.|||.||||||:|
  Rat   727 FARLSQMATILNLERVTEILDYWGA--NSGPLTWRLTPAEVRQVLALRIDFRNEDIKRLRL 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog4	NP_609413.1	Cog4	166..497	CDD:214809	127/335 (38%)
Cog4	NP_001101919.1	COG4	188..497	CDD:400560	120/313 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341935
Domainoid	1	1.000	232	1.000	Domainoid score	I2342
eggNOG	1	0.900	-	-		E1_KOG0412
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7155
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1088
OMA	1	1.010	-	-		QHG54204
OrthoDB	1	1.010	-	-		D139188at33208
OrthoFinder	1	1.000	-	-		FOG0004935
OrthoInspector	1	1.000	-	-		oto98243
orthoMCL	1	0.900	-	-		OOG6_102876
Panther	1	1.100	-	-	LDO	PTHR24016
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4025
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770