Protein Alignment Cog4 and COG4

DIOPT Version :10

• Sequence 1: NP_609413.1
• Gene: Cog4 / 34442
• FlyBaseID: FBgn0032258
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_056201.2
• Gene: COG4 / 25839
• HGNCID: 18620
• Length: 789
• Species: Homo sapiens
• Alignment Length: 774
• Identity: 299/774 - (38%)
• Similarity: 469/774 - (60%)
• Gaps: 41/774 - (5%)

  Fly    16 EQVDETLQRIADEEAKVNEKLESLLAKQCQIEAKMSGIGRSLSLLHTVDSDSNKLNDQIVNTAQL 80
            ::::...:|:..||..|..:|::||.:|..||:||..:.|....|..::.|:.:|...|..|..|
Human    44 QELEAVYERLCGEEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNL 108

  Fly    81 AESVSAKVRRLDLARCRASECQQRVHDLIDLHLCSQGVVKAIGEEDYEKSATHIARFLAMDQQLL 145
            ||:||:|||:||||:.|..:..||..|::||..|..||..|:..||||::|.|..|:|.:|:.::
Human   109 AENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDKSVI 173

  Fly   146 RRTADDVQGSITSVSDAVKTLEDATEKTRVLIAKRFDEAVKADDLASVERFFKIFPLVGCHRTGI 210
            ..:....:||:...:  :|.|::|.::.:.::|::|..|.|..||..||||||||||:|.|..|:
Human   174 ELSRQGKEGSMIDAN--LKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGL 236

  Fly   211 EKFSLYICQKLANKAQKELRNAQDIAKAESRLQLAYADRLTAILENFARVVEVNQPIIEAFYGQA 275
            .|||.|:|:::|:||::.|........::.|..:.:||.||.:.|..||:||.:|||:|.:||
Human   237 RKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYG-- 299

  Fly   276 SSSLIDMVSILQHECDTEVKNLLMEFNKNRQIQYRSKQVNESTQRSAGGGNLGSNSIQALGHYRK 340
            ...|..::..||.|||.:|:.::.:|.|.|....:.:.|..:..|::
Human   300 PGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNS------------------ 346

  Fly   341 PSGGSVDKLNPKEIDAIIAEITVMHARVELYFRFMRRRLQVHVE---TCVPEKEQFDIMERYEKI 402
                :.:|:.|:|:|.|:.|:|:|:||.|||.||:::|:....|   :...|:.:.:..:..:|:
Human   347 ----TTEKIEPRELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKL 407

  Fly   403 MKNSDLRRQMQEILSTYLLLERYFMEESVLKAIGLDTYESGQQCSSMVDDVFFILRKSIRRALTT 467
            :.|..|...|||::..|:.:|.|||.|:|.||:.|||||.||..||||||||:|::|.|.|||::
Human   408 LNNCLLSCTMQELIGLYVTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSS 472

  Fly   468 QSINGTCAVINNVAACLDGDFVNALKAPLKSGYPSGYID-----LAQAYNAIQTSLQQGKLHS-- 525
            .||:..||:||.....|:.||.:.|...|:.|:|:....     :..|.|.:.:||||||..:
Human   473 SSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKG 537

  Fly   526 -SDADRGRANFLVQLNNADISTEYIETLCQTMEQEIAGTFPQTTQVERQM--LDSCLTELKAVRD 587
             ...|..:.:|||.|||.::.:|.|.||.:|:|.:....|.|....|:..  .||||::|.||.:
Human   538 IESTDEAKMSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSN 602

  Fly   588 ALKATVDFGMQQLRSSVIKPRLNPWINQFLNYSHNLNEEELAAYEAGETFVQFFIVQLDGLLNSF 652
            ..:..:..|:.:|.|:.|||::.||||.|.:.|||:.|||...|||.:.:||.||:.|:..:..|
Human   603 KFRDLLQEGLTELNSTAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEF 667

  Fly   653 KNSLSPRNYDALVSILATEVTIQLERAIKKISFNRLGGLVLDQEVRALGSYLTGATSWSVRDKMT 717
            |.||||..||:|..::.:.|.::||:.:.|.:|||||||..|:|:|:|.:|||..|:|::|||..
Human   668 KASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFA 732

  Fly   718 RISQIATLLNLDKITELSEYWNPENNKEMSSWHLTPNEVRTFLTLRNDFRIEDIKRLQL 776
            |:||:||:|||:::||:.:||.|  |....:|.|||.|||..|.||.|||.||||||:|
Human   733 RLSQMATILNLERVTEILDYWGP--NSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog4	NP_609413.1	Cog4	166..497	CDD:214809	122/333 (37%)
COG4	NP_056201.2	COG4	192..501	CDD:462425	122/332 (37%)