DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cog4 and COG4

DIOPT Version :9

Sequence 1:NP_609413.1 Gene:Cog4 / 34442 FlyBaseID:FBgn0032258 Length:776 Species:Drosophila melanogaster
Sequence 2:NP_056201.2 Gene:COG4 / 25839 HGNCID:18620 Length:789 Species:Homo sapiens


Alignment Length:774 Identity:299/774 - (38%)
Similarity:469/774 - (60%) Gaps:41/774 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 EQVDETLQRIADEEAKVNEKLESLLAKQCQIEAKMSGIGRSLSLLHTVDSDSNKLNDQIVNTAQL 80
            ::::...:|:..||..|..:|::||.:|..||:||..:.|....|..::.|:.:|...|..|..|
Human    44 QELEAVYERLCGEEKVVERELDALLEQQNTIESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNL 108

  Fly    81 AESVSAKVRRLDLARCRASECQQRVHDLIDLHLCSQGVVKAIGEEDYEKSATHIARFLAMDQQLL 145
            ||:||:|||:||||:.|..:..||..|::||..|..||..|:..||||::|.|..|:|.:|:.::
Human   109 AENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDKSVI 173

  Fly   146 RRTADDVQGSITSVSDAVKTLEDATEKTRVLIAKRFDEAVKADDLASVERFFKIFPLVGCHRTGI 210
            ..:....:||:...:  :|.|::|.::.:.::|::|..|.|..||..||||||||||:|.|..|:
Human   174 ELSRQGKEGSMIDAN--LKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGL 236

  Fly   211 EKFSLYICQKLANKAQKELRNAQDIAKAESRLQLAYADRLTAILENFARVVEVNQPIIEAFYGQA 275
            .|||.|:|:::|:||::.|........::.|..:.:||.||.:.|..||:||.:|||:|.:||  
Human   237 RKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYG-- 299

  Fly   276 SSSLIDMVSILQHECDTEVKNLLMEFNKNRQIQYRSKQVNESTQRSAGGGNLGSNSIQALGHYRK 340
            ...|..::..||.|||.:|:.::.:|.|.|....:.:.|..:..|::                  
Human   300 PGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNS------------------ 346

  Fly   341 PSGGSVDKLNPKEIDAIIAEITVMHARVELYFRFMRRRLQVHVE---TCVPEKEQFDIMERYEKI 402
                :.:|:.|:|:|.|:.|:|:|:||.|||.||:::|:....|   :...|:.:.:..:..:|:
Human   347 ----TTEKIEPRELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKL 407

  Fly   403 MKNSDLRRQMQEILSTYLLLERYFMEESVLKAIGLDTYESGQQCSSMVDDVFFILRKSIRRALTT 467
            :.|..|...|||::..|:.:|.|||.|:|.||:.|||||.||..||||||||:|::|.|.|||::
Human   408 LNNCLLSCTMQELIGLYVTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSS 472

  Fly   468 QSINGTCAVINNVAACLDGDFVNALKAPLKSGYPSGYID-----LAQAYNAIQTSLQQGKLHS-- 525
            .||:..||:||.....|:.||.:.|...|:.|:|:....     :..|.|.:.:||||||..:  
Human   473 SSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKG 537

  Fly   526 -SDADRGRANFLVQLNNADISTEYIETLCQTMEQEIAGTFPQTTQVERQM--LDSCLTELKAVRD 587
             ...|..:.:|||.|||.::.:|.|.||.:|:|.:....|.|....|:..  .||||::|.||.:
Human   538 IESTDEAKMSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSN 602

  Fly   588 ALKATVDFGMQQLRSSVIKPRLNPWINQFLNYSHNLNEEELAAYEAGETFVQFFIVQLDGLLNSF 652
            ..:..:..|:.:|.|:.|||::.||||.|.:.|||:.|||...|||.:.:||.||:.|:..:..|
Human   603 KFRDLLQEGLTELNSTAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQFILNLEQQMAEF 667

  Fly   653 KNSLSPRNYDALVSILATEVTIQLERAIKKISFNRLGGLVLDQEVRALGSYLTGATSWSVRDKMT 717
            |.||||..||:|..::.:.|.::||:.:.|.:|||||||..|:|:|:|.:|||..|:|::|||..
Human   668 KASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFA 732

  Fly   718 RISQIATLLNLDKITELSEYWNPENNKEMSSWHLTPNEVRTFLTLRNDFRIEDIKRLQL 776
            |:||:||:|||:::||:.:||.|  |....:|.|||.|||..|.||.|||.||||||:|
Human   733 RLSQMATILNLERVTEILDYWGP--NSGPLTWRLTPAEVRQVLALRIDFRSEDIKRLRL 789

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cog4NP_609413.1 Cog4 166..497 CDD:214809 122/333 (37%)
COG4NP_056201.2 COG4 192..501 CDD:285513 122/332 (37%)
Sec6 <551..788 CDD:303062 108/238 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148062
Domainoid 1 1.000 236 1.000 Domainoid score I2354
eggNOG 1 0.900 - - E1_KOG0412
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7155
Inparanoid 1 1.050 550 1.000 Inparanoid score I1143
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54204
OrthoDB 1 1.010 - - D139188at33208
OrthoFinder 1 1.000 - - FOG0004935
OrthoInspector 1 1.000 - - oto91155
orthoMCL 1 0.900 - - OOG6_102876
Panther 1 1.100 - - LDO PTHR24016
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R221
SonicParanoid 1 1.000 - - X4025
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.800

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