DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cog4 and cog4

DIOPT Version :9

Sequence 1:	NP_609413.1	Gene:	Cog4 / 34442	FlyBaseID:	FBgn0032258	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_588155.1	Gene:	cog4 / 2539017	PomBaseID:	SPCC338.13	Length:	738	Species:	Schizosaccharomyces pombe

Alignment Length:	778	Identity:	164/778 - (21%)
Similarity:	322/778 - (41%)	Gaps:	141/778 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LDIGTNE--QVDETLQRIAD---EEAKVNEKLESLLAKQCQIEAKMSGIGRSLSLLHTVDSDSNK 69
            :||..|:  .:.:..||..|   |..:.:||||.||:.....|...|.|......|........:
pombe     1 MDISINDCTDISQIKQRFHDLQVESQRTDEKLERLLSDAQPTEKFNSLIKNMAERLVLFVGQIEE 65

  Fly    70 LNDQIVNTAQLAESVSAKVRRLDLARCRASECQQRVHDLIDLHLCSQGVVKAIGEEDYEKSATHI 134
            |.|...||..::|.|..:::.:|..:.|..||...|..:.|...|.|.:.:|:..:.:||:|..:
pombe    66 LKDAFCNTTIVSEEVIERIKSVDREQNRIKECLLFVRQVRDFKECLQDLNRAMHHQQWEKAADLV 130

  Fly   135 ARFLAMDQQLLR-RTADDVQGSITSVSDAVKTLEDATEKTRVLIAKRFDEAVKADDLASVERFFK 198
            .|..:....::. :.|..|..:.......:.||::.||....|..:.|.:|.:..|...:.|:||
pombe   131 HRASSTSPAIIEGKFAHAVVPTAEQPLAPMDTLKEITESLHTLFWREFHKAARNQDQKEITRYFK 195

  Fly   199 IFPLVGCHRTGIEKFSLYICQKLANKAQKELRNAQDIAKAESRLQLAYADRLTAILENFARVVEV 263
            :|||:|..:.|:|.:..:....:|:||:..|......|       |.:|...|.::|:.|.::..
pombe   196 LFPLIGKEKEGLEAYWHFFGGIIASKARATLDEPPTHA-------LFFAQAFTGLVEHVASIIRA 253

  Fly   264 NQPIIEAFYGQASSSLIDMVSILQHECDTE-------------VKNLLMEFNKNRQIQYRSKQVN 315
            :.|:::.:|  .:.:.|.::..||.:||.:             :.||:......:.|...:|..|
pombe   254 HTPLVQKYY--KAKNTITVIEKLQGDCDRQGSIIVNTMFDVRRIDNLVSSIASYKYILLHAKLKN 316

  Fly   316 ESTQRSAGGGNLGSNSIQALGHYRKPSGGSVDKLNP--KEIDAIIAEITVMHARVELYFRFMRRR 378
            .:                .:...::....|:..|:|  .|:.||:::..:.    :::...:..|
pombe   317 RA----------------FVSDQKELERVSLQTLHPILNEMSAIVSKWNIS----KIFISRLVLR 361

  Fly   379 LQVHVETCVPEKEQFDIM-------ERYEKIMKNSDLRRQMQEILSTYLLLERYFMEESVLKAIG 436
            |.....|......|.:::       .:.|.::|        :::|.:.|.||.|:...|:..::.
pombe   362 LSQSDGTSNDPSVQDNLICASIFNSSKMELLLK--------KQLLPSLLQLETYYFRRSIETSLE 418

  Fly   437 LDTY--ESGQQCSSMVDDVFFILRKSIRRALTTQSINGTCAVINNVAACLDGDFVNALKAP-LKS 498
            |:.|  :.....||:||||.::.::..:||..|            |::.....|||....| |::
pombe   419 LEEYYTKVSPWMSSIVDDVMYVTKQVFQRAFFT------------VSSLFFTRFVNESLIPILRN 471

  Fly   499 GYPSGYI----DLAQAYNAIQTSLQQGKLHSSDADRGRANFLVQLNNADISTEYIETLCQTMEQE 559
            .|   |:    :|....|.|:...|:.|..:|...:...|::..:|:|.:|.:|::::
pombe   472 DY---YVYLSHNLLTVCNIIKAQFQRLKNANSIPAKQVENYITLVNSASLSKQYLKSI------- 526

  Fly   560 IAGTFPQTTQVERQMLDSCLTELKAVRDALKATVDFGMQQLRSSVIKPRLNPW------------ 612
            :.|...:..:|.....|..|.: |::.:.|:.||:|      .::.|...|.:
pombe   527 VDGVSSRLEEVFAFAKDQKLVK-KSIDNFLQLTVNF------ENLCKTSFNMYFPIFLLPRIEQC 584

  Fly   613 -------INQFLNYSHNLNEEELAAYEAGETFVQFFIVQLDG------LLNSFKNSLSPRNYDAL 664
                   ||..|:|.....|.|   :|      :..:.:|..      ||..|    :|.|..:|
pombe   585 IDDSFDGINYVLSYEDYTKETE---HE------RLVVTRLRSVWDRVLLLEQF----TPENQLSL 636

  Fly   665 VSILATEVTIQLERAI-KKISFNRLGGLVLDQEVRALGSYLTGATSWSVRDKMTRISQIATLL 726
            .|:...:....:|..| .||.:|..|.:.|:.::.:|.:..:...: ::|....|:.:|..||
pombe   637 RSMACEKAASYIENLILYKIQWNDYGAMALENDISSLITIFSNDQA-NLRHSFERLQEILILL 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cog4	NP_609413.1	Cog4	166..497	CDD:214809	72/355 (20%)
cog4	NP_588155.1	Cog4	163..481	CDD:214809	75/369 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	71	1.000	Domainoid score	I2626
eggNOG	1	0.900	-	-		E1_KOG0412
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	124	1.000	Inparanoid score	I1465
OMA	1	1.010	-	-		QHG54204
OrthoFinder	1	1.000	-	-		FOG0004935
OrthoInspector	1	1.000	-	-		oto101853
orthoMCL	1	0.900	-	-		OOG6_102876
Panther	1	1.100	-	-	LDO	PTHR24016
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R221
SonicParanoid	1	1.000	-	-		X4025
TreeFam	1	0.960	-	-
	13	12.860