DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cog4 and cogc-4

DIOPT Version :9

Sequence 1:	NP_609413.1	Gene:	Cog4 / 34442	FlyBaseID:	FBgn0032258	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_493966.1	Gene:	cogc-4 / 173518	WormBaseID:	WBGene00021784	Length:	801	Species:	Caenorhabditis elegans

Alignment Length:	786	Identity:	237/786 - (30%)
Similarity:	405/786 - (51%)	Gaps:	71/786 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EAKVNEKLESLLAKQCQIEAKMSGI-----GRSLSLLHT--------VDSDSNKLNDQIVNTAQL 80
            |.::.::.|..:.|...|..:.:.|     .||..|..|        |::.:.:|...:.|.:.|
Worm    48 ELEIKKREEERIEKDIAIILEENTIDGGEQNRSFGLAVTRLNNHMLVVENSAKQLTSALKNISVL 112

  Fly    81 AESVSAKVRRLDLARCRASECQQRVHDLIDLHLCSQGVVKAIGEEDYEKSATHIARFLAMDQQLL 145
            |:::|.:|..||:|:.|...|.|...|:.||.:|::|:..||..||:|.::.||.|||.:||.:.
Worm   113 ADTISGRVSALDVAKTRVVGCLQLAGDMRDLGVCAEGIDDAIRSEDFETASQHIHRFLTLDQAVF 177

  Fly   146 RRTADDVQGSITSVSDAVKTLEDATEKTRVLIAKRFDEAVKADDLASVERFFKIFPLVGCHRTGI 210
            :......:.:..|:..:.:.|..|.|:...::..|..|:|:..|:|.::||.|:|||:.....|:
Worm   178 QIREFKQKDATDSIRHSYEVLSSAKERLSKILKSRLTESVQKGDVAEMQRFIKMFPLIHEPDEGL 242

  Fly   211 EKFSLYICQKLANKAQKELRNAQDIAKA----ESRLQLAYADRLTAILENFARVVEVNQPIIEAF 271
            :::|:::.||:...|:..|.    |.||    ::|..:.|||.|....|..|.::|.|.|::|..
Worm   243 QRYSVFLNQKIDKLAEDNLA----IMKAGGTDDNRRNVLYADTLFMFFEGVAEIIESNLPVLEHS 303

  Fly   272 YGQASSSLIDMVSILQHECDTEVKNLLMEFNKNRQIQYRSKQVNESTQRSAGGGNLGSNSIQALG 336
            ||  ...|:|.:.|||...|...:.|..||:..|::.:.::.|::                  :.
Worm   304 YG--LEKLLDFMFILQARIDEFFRRLHEEFDTRRRLSHFNRLVDD------------------VI 348

  Fly   337 HYRKPSGGSVDKLNPKEIDAIIAEITVMHARVELYFRFMRRRLQVHVETCVP------EKEQFDI 395
            |.:|.:....|..:|.|||||.:||.:|:...|:|:||:.||:..:.....|      |:.:...
Worm   349 HQKKAAEAVEDAPDPMEIDAIASEICMMNTSAEMYWRFVSRRIGKNEVIRSPSGDGDDEENEEAR 413

  Fly   396 MERY-----------EKIMKNSDLRRQMQEILSTYLLLERYFMEESVLKAIGLDTYE-SGQQCSS 448
            .||:           ::::..|.:..:|||::..|.|||.::|.:||.|||..|..| :|...||
Worm   414 QERHRLRKEAKEQKMDQLLNRSRVGTKMQELIGNYCLLEHFYMLKSVQKAIKSDVKEDAGGLTSS 478

  Fly   449 MVDDVFFILRKSIRRALTTQSINGTCAVINNVAACLDGDFVNALKAPLKSGYPSGYIDLAQAYNA 513
            :||||.||:|||||||..:.:::..||.|||..|.:|......|:..::.||.:.....::|:
Worm   479 IVDDVVFIIRKSIRRAAGSGNVDSVCATINNATALIDTVVHGHLRQSIQQGYVTSSNFASEAF-- 541

  Fly   514 IQTSLQQGKLHSSDADRGRANFLVQLNNADISTEYIETLCQTMEQEIAGTFPQTTQVERQMLDSC 578
              |:.||||.....||..:..||:.|||:...:|.:..|.:.:..|.||.  :...||:..|:..
Worm   542 --TAYQQGKPVKEAADAQKEQFLLALNNSAKLSELLIELQKGLITEWAGV--KRPDVEKNKLEHS 602

  Fly   579 LTELKAVRDALKATVDFGMQQLRSSVIKPRLNPWINQFLNYSHNLNEEELAAYEAGETFVQFFIV 643
            .|:::.....|.:....|:::|..|..|.::....:.:......:..:::..|||.:.|::.|:.
Worm   603 TTQIEESAKKLASLAKHGVEELFKSAFKNKIKQGADPYQEIDRQMTMQDVEYYEAHDPFMEQFLA 667

  Fly   644 QLDGLLNSFKNSLSPRNYDALVSILATEVTIQLERAIKKISFNRLGGLVLDQEVRALGSYLTGAT 708
            |:|.||...:..|...||..|:.:.::|:..|:|:::.|..|||.|.|.||:|.|.:.:|||...
Worm   668 QIDRLLVENEPLLFADNYQTLLLLTSSEIARQIEQSLAKCQFNRYGALQLDREYRQICAYLTNVA 732

  Fly   709 SWSVRDKMTRISQIATLLNLDKITELSEYWNPENNKEMSS----WHLTPNEVRTFLTLRNDFRIE 769
            .||.|:|:.|:.||.:|||::.|.|..|.|:  |:|.|:|    ..||..|||..|.||.||...
Worm   733 GWSAREKVGRLGQIVSLLNVETIDEAMEVWH--NSKAMTSSATIRTLTLPEVRKVLALRADFPTV 795

  Fly   770 DIKRLQ 775
            .||.::
Worm   796 AIKSIE 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cog4	NP_609413.1	Cog4	166..497	CDD:214809	109/352 (31%)
cogc-4	NP_493966.1	Cog4	198..527	CDD:214809	109/352 (31%)
cogc-4	NP_493966.1	RINT1_TIP1	<562..789	CDD:282313	71/230 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160006
Domainoid	1	1.000	161	1.000	Domainoid score	I2447
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7155
Inparanoid	1	1.050	347	1.000	Inparanoid score	I1363
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54204
OrthoDB	1	1.010	-	-		D139188at33208
OrthoFinder	1	1.000	-	-		FOG0004935
OrthoInspector	1	1.000	-	-		oto20599
orthoMCL	1	0.900	-	-		OOG6_102876
Panther	1	1.100	-	-	LDO	PTHR24016
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R221
SonicParanoid	1	1.000	-	-		X4025
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940