DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cog4 and Cog4

DIOPT Version :9

Sequence 1:	NP_609413.1	Gene:	Cog4 / 34442	FlyBaseID:	FBgn0032258	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_598734.1	Gene:	Cog4 / 102339	MGIID:	2142808	Length:	785	Species:	Mus musculus

Alignment Length:	776	Identity:	304/776 - (39%)
Similarity:	474/776 - (61%)	Gaps:	45/776 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EQVDETLQRIADEEAKVNEKLESLLAKQCQIEAKMSGIGRSLSLLHTVDSDSNKLNDQIVNTAQL 80
            ::::...:|:..||..|.::|::||.:|..||:||..:.|....|..::.|:.:|...|..|..|
Mouse    40 QELEAVYERLCGEEKAVEKELDALLEQQNTIESKMVTLHRMGPSLQLIEGDAKQLAGMITFTCSL 104

  Fly    81 AESVSAKVRRLDLARCRASECQQRVHDLIDLHLCSQGVVKAIGEEDYEKSATHIARFLAMDQQLL 145
            ||:||:|||:||||:.|..:..||..|::||..|..||..|:..||||::|.||.|:|.:|:.::
Mouse   105 AENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRNEDYEQAAAHIHRYLCLDKSVI 169

  Fly   146 RRTADDVQGSITSVSDAVKTLEDATEKTRVLIAKRFDEAVKADDLASVERFFKIFPLVGCHRTGI 210
            ..:....:||:...:  :|.|::|.::.:.::|::|..|.|..||..||||||||||:|.|..|:
Mouse   170 ELSRQGKEGSMIDAN--LKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEDGL 232

  Fly   211 EKFSLYICQKLANKAQKELRNAQDIAKAESRLQLAYADRLTAILENFARVVEVNQPIIEAFYGQA 275
            .|||.|:|:::|:||::.|........::.|..:.:||.||.:.|..||:||.:|||:|.:||
Mouse   233 SKFSEYLCKQVASKAEENLLLVLGSDMSDRRAAVIFADTLTLLFEGIARIVETHQPIVETYYG-- 295

  Fly   276 SSSLIDMVSILQHECDTEVKNLLMEFNKNRQI--QYRSKQVNESTQRSAGGGNLGSNSIQALGHY 338
            ...|..::..||.||||:|:.::.:|.|.|..  |:|..|           .||..||
Mouse   296 PGRLFTLIKYLQVECDTQVEKVVNKFIKQRDYHQQFRLVQ-----------SNLMRNS------- 342

  Fly   339 RKPSGGSVDKLNPKEIDAIIAEITVMHARVELYFRFMRRRLQVHVE---TCVPEKEQFDIMERYE 400
                  :.:|:.|:|:|.::.|:|:|:||.|||.||:|:|:....|   :...|:.:.:..:..:
Mouse   343 ------ATEKIEPRELDPVLTEVTLMNARSELYLRFLRKRISADFEVGDSMASEEVKQEHQKCLD 401

  Fly   401 KIMKNSDLRRQMQEILSTYLLLERYFMEESVLKAIGLDTYESGQQCSSMVDDVFFILRKSIRRAL 465
            |::.|..|...|||::..|:.:|.|||.|:|.||:.|||||.||..||||||||:|::|.|.|||
Mouse   402 KLLNNCLLSCTMQELIGFYITMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRAL 466

  Fly   466 TTQSINGTCAVINNVAACLDGDFVNALKAPLKSGYPSGYID-----LAQAYNAIQTSLQQGKLHS 525
            ::.:|:..||:||.....|:.||.:.|...|:.|:|:..:.     :..|.|.:.:||||||..:
Mouse   467 SSSNIDCLCAMINLATRELEADFRDVLCNKLRMGFPATTLQDIQRGVTSAVNIMHSSLQQGKFDT 531

  Fly   526 ---SDADRGRANFLVQLNNADISTEYIETLCQTMEQEIAGTFPQTTQVERQM--LDSCLTELKAV 585
               ...|..:.:|||.|||.::.:|.|.||.:|:|.:....|.|....|:..  .||||::|.||
Mouse   532 KGIESTDEAKLSFLVTLNNVEVCSENISTLKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAV 596

  Fly   586 RDALKATVDFGMQQLRSSVIKPRLNPWINQFLNYSHNLNEEELAAYEAGETFVQFFIVQLDGLLN 650
            .:..:..:..|:.:|.||.:||::.||||.||:.||::.|||...|||.:.:||.||:.|:..:.
Mouse   597 SNKFRDLLQEGLAELNSSAVKPQVQPWINTFLSVSHSIEEEEFNDYEANDPWVQQFILNLEQQMA 661

  Fly   651 SFKNSLSPRNYDALVSILATEVTIQLERAIKKISFNRLGGLVLDQEVRALGSYLTGATSWSVRDK 715
            .||.||||..||:|..::.:.|.::||:.:.|.:|||||||..|:|:|:|.:|||..|:|::|||
Mouse   662 EFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDK 726

  Fly   716 MTRISQIATLLNLDKITELSEYWNPENNKEMSSWHLTPNEVRTFLTLRNDFRIEDIKRLQL 776
            ..|:||:||:|||:::||:.:||..  |....:|.|||.|||..|.||.|||.||||||:|
Mouse   727 FARLSQMATILNLERVTEILDYWGA--NSGPLTWRLTPAEVRQVLALRIDFRNEDIKRLRL 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cog4	NP_609413.1	Cog4	166..497	CDD:214809	127/335 (38%)
Cog4	NP_598734.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Interaction with SCFD1. /evidence=ECO:0000250\|UniProtKB:Q9H9E3	2..84		13/43 (30%)
		Interaction with STX5. /evidence=ECO:0000250\|UniProtKB:Q9H9E3	85..153		29/67 (43%)
		COG4	188..497	CDD:285513	120/313 (38%)
		RINT1_TIP1	<586..772	CDD:282313	80/187 (43%)
		D domain. /evidence=ECO:0000250\|UniProtKB:Q9H9E3	618..740		56/121 (46%)
		E domain, essential for proper cell surface glycosylation. /evidence=ECO:0000250\|UniProtKB:Q9H9E3	741..785		20/43 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838155
Domainoid	1	1.000	232	1.000	Domainoid score	I2416
eggNOG	1	0.900	-	-		E1_KOG0412
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7155
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1123
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54204
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004935
OrthoInspector	1	1.000	-	-		oto94740
orthoMCL	1	0.900	-	-		OOG6_102876
Panther	1	1.100	-	-	LDO	PTHR24016
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R221
SonicParanoid	1	1.000	-	-		X4025
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790