DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip75 and GCP4

DIOPT Version :9

Sequence 1:	NP_609412.1	Gene:	Grip75 / 34441	FlyBaseID:	FBgn0026431	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_190944.2	Gene:	GCP4 / 824543	AraportID:	AT3G53760	Length:	745	Species:	Arabidopsis thaliana

Alignment Length:	758	Identity:	178/758 - (23%)
Similarity:	327/758 - (43%)	Gaps:	142/758 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIHDLLLAC----------RSHNPEQLGIKAFNETTVID-----------QFIHPCEREIFMDII 44
            |:|:||||.          .....:.||: |||..:.:.           .||.|.||::...:|
plant     1 MLHELLLALLGFTGDLIVDEREQRKTLGL-AFNSDSPLSDECTFKLAPDISFIEPSERDLIERLI 64

  Fly    45 KIIKVYQEVEQF---------------THSSGRKSDTHGELPDSLHGYYLLNLAKGIEMALEEYY 94
            |:...|:|:::|               .|...|..:...:..:.....|...:|.||...|..|.
plant    65 KLGFYYRELDRFAKKSRNLSWIRSVTSVHPLERADELSKQSREKKPSVYRRAIANGIGEILSVYR 129

  Fly    95 AEIGRLEKYCLGNERNSLSYVYNALYAKFPLLVFMRNLITEIHVLNLRGCVLLHNLHQQCEHGDI 159
            :.:..:|:..|......|:.|...|...|.|...:..:|.||...::||..||:.|:::|..|..
plant   130 SAVLHIEQKLLAETTPILATVTEGLNKFFVLFPPLYEVILEIERDDIRGGQLLNVLNKRCHCGVP 194

  Fly   160 QLEKAIKIIMKPVKNAFFSSLAHWLLFGVIDDVHSEFFIKFTPTDAVDGSSFSKSATCSLLSA-- 222
            :|...::.::.......::.||.|:::|::.|.|.|||||......:|..|..:..:..|...
plant   195 ELRTCLQRLLWNGHQVMYNQLAAWMVYGILQDPHGEFFIKRQDDGDLDHRSSQEEVSEKLARTSV 259

  Fly   223 -EKNPEDYIWQYEVNMSQLPGFFSIVLAEKVLFVGQTVLVFK-----------------MGRNVK 269
             |.:..|:...:.:::..||.:..:.|.|.:||.|:.:.|.:                 |..:.:
plant   260 HETSLTDWHSGFHISLDMLPDYIPMRLGESILFAGKAIRVLRNPSPAFQFQKDKSFQQTMRGSQR 324

  Fly   270 VKN-------KTDPLAAKLAELDSDDIYQLWSGR---ESEFFK---MVVDLSNEDTINVFRLEKV 321
            ::.       :|:      .|||:|    |..|.   :||..|   |:.||......:....|..
plant   325 IRGFMHSDFPETE------TELDAD----LTGGELLPQSEADKIEAMLKDLKESSEFHKRSFECT 379

  Fly   322 IIDIKNYVSARLSEIAVNEVDLERQMGLIKDFFLLGRGEFYLEFC--SQMVGTMETYREERFKNV 384
            :..::...::.|.::.|...||...:..:||:|||.:|:|:..|.  |:.:..:...:.....::
plant   380 VDSVRAIAASHLWQLVVVRADLNGHLKALKDYFLLEKGDFFQCFLEESRQLMRLPPRQSTGESDL 444

  Fly   385 TRSFELAATVTGITDD---------LDKFSLICQRS-----------TSEPDDTSDFNF--LQGL 427
            ...|:||||.|...:|         :..|.:..:.|           |.:.:.|||.:.  ...:
plant   445 MVPFQLAATKTIAEEDKYFSRVSLRMPSFGVTVRSSQADMVRSKVSLTGKANLTSDTSVDGWDAI 509

  Fly   428 SLKYEYEWPLNLLFSPTTIERYNNIFRFLLIIRTYQYEIQRVWAKQTWR-----AKSAKD----- 482
            :|:|..:||:.|.|:...:.:|..:|::|:.::..|.|:::.||....:     |:..||
plant   510 ALEYSVDWPMQLFFTQEVLSKYLKVFQYLIRLKRTQMELEKSWASVMHQDHIESAQHRKDGLNGS 574

  Fly   483 --------VPPNNKIITLRNYLMFFLNNMQYYIQVDVLESQFGILMNVIKSRSDFEVIQRAHTVF 539
                    :.|..::   |.::.|.:.|:|:||||||:|||:.:|...|....||..:...|..:
plant   575 TSQQRRQGIRPMWRV---REHMAFLIRNLQFYIQVDVIESQWKVLQTHIHDSQDFTELVGFHQEY 636

  Fly   540 LANVLSHCFLLNESETQLNVTGSQNRNPIYGTLLKLFGICEKFAHMTQTKDPSDDLEDEVDQLNE 604
            |:.::|..||         ..||.:|  |..:::||   |.:|....:.:: |:....|::.:.|
plant   637 LSALISQSFL---------DIGSVSR--ILDSIMKL---CLQFCWNIENQE-SNPNTSELENIAE 686

  Fly   605 SFGVQIASLIQLLVDVKSA-SCLGP-LSQLLLRLDFNCWFSAS 645
            .|..:..||..:|...|.| |...| |.:.||||:||.::.|:
plant   687 EFNKKSNSLYTILRSSKLAGSQRAPFLRRFLLRLNFNSFYEAT 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip75	NP_609412.1	Spc97_Spc98	25..548	CDD:282045	138/623 (22%)
GCP4	NP_190944.2	GCP_N_terminal	50..302	CDD:407574	60/251 (24%)
GCP4	NP_190944.2	Spc97_Spc98	403..726	CDD:398000	87/340 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	92	1.000	Domainoid score	I2602
eggNOG	1	0.900	-	-		E1_KOG2065
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8690
Inparanoid	1	1.050	166	1.000	Inparanoid score	I1578
OMA	1	1.010	-	-		QHG58740
OrthoDB	1	1.010	-	-		D1137416at2759
OrthoFinder	1	1.000	-	-		FOG0007435
OrthoInspector	1	1.000	-	-		oto3579
orthoMCL	1	0.900	-	-		OOG6_103557
Panther	1	1.100	-	-	LDO	PTHR19302
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5566
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840