DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip75 and tubgcp4

DIOPT Version :9

Sequence 1:	NP_609412.1	Gene:	Grip75 / 34441	FlyBaseID:	FBgn0026431	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_001072677.1	Gene:	tubgcp4 / 780134	XenbaseID:	XB-GENE-491696	Length:	665	Species:	Xenopus tropicalis

Alignment Length:	711	Identity:	200/711 - (28%)
Similarity:	339/711 - (47%)	Gaps:	115/711 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIHDLLLACRSHNPEQLGIKAFNETTVID-----QFIHPCEREIFMDIIKI----IKVYQEVEQF 56
            |||:||||...:..   .|..:|:.|.:.     .|:||.|..:...:.|:    |:..:.:||:
Frog     1 MIHELLLALSGYPG---SIFTWNKRTGLQVVQDVPFLHPGETNVLNRLCKLGTDYIRFTEFIEQY 62

  Fly    57 THSSGRKSDTH----GELPDSLHGYYLLNLAKGIEMALEEYYAEIGRLEKYCLGNERNSLSYVYN 117
            | ...::.|.|    |::  .|||.||....:|::..|:.|...:..||:..|.:...|:|::..
Frog    63 T-GHVQQQDHHPSQQGQV--GLHGIYLRAFCRGLDSILQPYRQALLDLEQEFLADPHLSISHINY 124

  Fly   118 AL---YAKFPLLVFMRNLITEIHVLNLRGCVLLHNLHQQCEHGDIQLEKAIKIIMKPVKNAFFSS 179
            :|   :..||.::.   ::.:|....:.||.:|..:::....|...:..|::.|:.......:..
Frog   125 SLDQFHLLFPSVMV---VVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCHGVMYKQ 186

  Fly   180 LAHWLLFGVIDDVHSEFFIKFTPTD----------------AVDGSSFSKSATCSLLSAEKNPED 228
            |:.|:|.|::.|.:.|||::..|:.                .:.|....:.....|:..|.....
Frog   187 LSAWMLHGLLLDQYEEFFVRQGPSSNLAASSEEDDDDLGIGGLTGKQLRELQDLRLIEEENMLAP 251

  Fly   229 YIWQYEVNMSQLPGFFSIVLAEKVLFVGQTVLVFK-----MGRNVKV-KNKTDPLAAKLAELDSD 287
            .:.|:.:....||.:..:.:|||:||||::|.:|:     |.|...: ||:.|..||:|..|...
Frog   252 SLKQFSLRAEMLPSYIPVRVAEKILFVGESVQMFENQNANMSRTGSILKNQEDTFAAELHRLKQQ 316

  Fly   288 DIYQLWSGRESEFFKMVVDLSNEDTINVFRLEKVIIDIKNYVSARLSEIAVNEVDLERQMGLIKD 352
            .::.|            ||           .|.|:..|::.|:..|.::.|.|.||..|:.:|||
Frog   317 PLFSL------------VD-----------FESVLDRIRSTVAEHLWKLMVEESDLLGQLKIIKD 358

  Fly   353 FFLLGRGEF---YLEFCSQMVGTMETYREERFKNVTRSFELAATVTGITDD--LDKFSLIC---- 408
            |:||||||.   :::....|:.|..|...|...||  :|:|:|....:.||  |...:|..
Frog   359 FYLLGRGELFQAFIDIAQNMLKTPPTAVTEHDINV--AFQLSAHKVLLDDDNLLPLLNLTIDYHG 421

  Fly   409 --QRSTSEP-----DDTS----DFNFLQGLSLKYEYEWPLNLLFSPTTIERYNNIFRFLLIIRTY 462
              .:..|:|     .|||    ..:....|.|.|:.:|||::||:|..:|:||.:|::||.:|..
Frog   422 KEHKDMSQPREGPSRDTSPREPPISGWAALGLSYKVQWPLHILFTPAVLEKYNVVFKYLLSVRRV 486

  Fly   463 QYEIQRVWAKQTWRAKSAKDVPPNNKII---TLRNYLMFFLNNMQYYIQVDVLESQFGILMNVIK 524
            |.|:|..||.|..|    |.:..|....   .|||::.|.::|:|||:|||||||||..|:..|.
Frog   487 QSELQHCWALQMQR----KHLESNKTDAIKWRLRNHMAFLVDNLQYYLQVDVLESQFSQLLQQIN 547

  Fly   525 SRSDFEVIQRAHTVFLANVLSHCFLLNESETQLNVTGSQNRNPIYGTLLKLFGICEKFAHM-TQT 588
            |..|||.|:.||..||:|:|:..|:|              ..|::..|.::..:|..|..: :|.
Frog   548 STRDFESIRLAHDHFLSNLLAQSFIL--------------LKPVFHCLNEILDLCHSFCSLVSQN 598

  Fly   589 KDPSDDL-EDEVDQLNESFGVQIASLIQLLVDVKSASCLGPLSQLLLRLDFNCWFSASHNT 648
            ..|.|:. ..::|.|.:.|..|.:.|.::|..|::......|:|||||||:|.:::.:..|
Frog   599 LGPLDERGAGQLDILVKGFSCQSSLLFRILSSVRNHQINPDLAQLLLRLDYNKYYTQAGGT 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip75	NP_609412.1	Spc97_Spc98	25..548	CDD:282045	165/583 (28%)
tubgcp4	NP_001072677.1	GCP_N_terminal	2..346	CDD:375250	86/375 (23%)
tubgcp4	NP_001072677.1	Spc97_Spc98	349..653	CDD:367830	110/323 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4923
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8690
Inparanoid	1	1.050	207	1.000	Inparanoid score	I3611
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1137416at2759
OrthoFinder	1	1.000	-	-		FOG0007435
OrthoInspector	1	1.000	-	-		oto102716
Panther	1	1.100	-	-	LDO	PTHR19302
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4584
SonicParanoid	1	1.000	-	-		X5566
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190