DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grip75 and tubgcp3

DIOPT Version :9

Sequence 1:	NP_609412.1	Gene:	Grip75 / 34441	FlyBaseID:	FBgn0026431	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	XP_005171052.1	Gene:	tubgcp3 / 563517	ZFINID:	ZDB-GENE-030616-538	Length:	906	Species:	Danio rerio

Alignment Length:	687	Identity:	144/687 - (20%)
Similarity:	262/687 - (38%)	Gaps:	134/687 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 QFIHPCEREIFMDI---IKIIKVYQEVEQ------FTHSSGRK-SDTHGELPDSLHGYYLLNLAK 84
            :||..|..|....|   :.:.|..::...      :.|:..|| :|:|.  .|...|....:...
Zfish   262 KFIKMCSPENCYKIDSKVPLCKSLRDTSSRLAELGWLHNKIRKYTDSHS--LDRAFGLVGQSFCA 324

  Fly    85 GIEMALEEYYAEIGRLEKYCLGNERNSLSYVYNALYAKFPLLVFMRNLITEIHVL--------NL 141
            .:...|:|||..:..|.......:...::...::......|||:..:....:..|        ..
Zfish   325 ALHQELKEYYRLLSVLHAQLQVEDDQGVNMSVDSSLTLRRLLVWTYDPKVRLKTLAALVDYCQGR 389

  Fly   142 RGCVLLHNLHQQCEHGDIQLEKAIKIIMKPVKNAFFSSLAHWLLFGVIDDVHSEFFIKFTPTDAV 206
            :|..|...:|...:.||..:...|:.|:..|.:...:.|..|:..|.::|.:.|||:...||...
Zfish   390 KGGELATAVHAYGKTGDPNMRALIQHILGLVSHPILNFLYRWIYDGELEDTYHEFFVASDPTVKT 454

  Fly   207 DGSSFSKSATCSLLSAEKNPEDYIW--QYEVNMSQLPGFFSIVLAEKVLFVGQTVLVFKMGRNVK 269
                                 |.:|  :|.:..|.:|.|.::..|.|||.:|:::...    :..
Zfish   455 ---------------------DRLWHDKYSLRKSMIPSFITMDQARKVLLIGKSINFL----HQV 494

  Fly   270 VKNKTDP---LAAKLAELDSDDIYQLWSGRESEFFKMVVDLSNEDTINVFRLEKVIIDI--KNYV 329
            ..::|.|   :.|..::....|..:|::..|.. |:..:|.:      .|...|.::|:  |||
Zfish   495 CHDRTPPGKIMPASKSKDSPKDAAELFTDLEGT-FQSKIDAA------YFETSKYLLDVLNKNY- 551

  Fly   330 SARLSEIAVNEVDLERQMGLIKDFFLLGRGEFYLEFCSQMVGTMETYREERFK--------NVTR 386
                        .|...:..::.:.|||:|:|....       |:..:.|..:        |:|.
Zfish   552 ------------QLLEHLQAMRRYLLLGQGDFIRHL-------MDLLKPELARPATTLYQHNLTG 597

  Fly   387 SFELAATVTGITDDLDKF--SLICQRSTSEPDDTSDFNFLQGLSLKYEYEWPLNLLFSPTTIERY 449
            ..|.|...|....|..:.  .|..:.....|.||....|    ||.|..|.|:..:|:...:..|
Zfish   598 ILETAVRATNAQFDSPEILKRLDVRLLEVSPGDTGWDVF----SLDYHVEGPIATVFTRECMSHY 658

  Fly   450 NNIFRFLLIIRTYQYEIQRVWAKQTWRAKSAKDVPPNNKII----TLRNYLMFFLNNMQYYIQVD 510
            ..:|.||...:..:|.:..:|..|...||..|.:|..:.::    .|.:.::.|::.|||||..:
Zfish   659 LRVFNFLWRAKRMEYILTDIWKGQMCNAKLLKSMPELSGVLHQCHVLASEMVHFIHQMQYYITFE 723

  Fly   511 VLESQFGILMNVIKSRSDFEVIQRAHTVFLANVLSHCFLLNESETQLN--------VTGSQN-RN 566
            |||..:..|.|.::...|.:.|..||.|||..::|.|.|...:.:.||        :...|| ::
Zfish   724 VLECSWDELWNKVQQAQDLDHIIAAHDVFLDTIISRCLLDVNNRSLLNQLRAVFDQIIEFQNAQD 788

  Fly   567 PIYGTLLK-------------------LFGI-----CEKFAHMTQTKDPSDDLEDEVDQLNESFG 607
            .:|.:.|:                   .:|:     .|:...:.:.||....:..::..|...:.
Zfish   789 TLYRSALEELQLRIQFEDKKRQREEMAEWGVTAEQEAEENRRVQEFKDTIPKMCSQLRLLTHFYQ 853

  Fly   608 VQIASLIQLLVDVKSASCLGPLSQLLLRLDFNCWFSA 644
            ..:...::||:.....|    |..|..|||||..:.|
Zfish   854 GIVQEFLRLLMTCSDES----LQFLSFRLDFNEHYKA 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip75	NP_609412.1	Spc97_Spc98	25..548	CDD:282045	120/556 (22%)
tubgcp3	XP_005171052.1	Spc97_Spc98	251..761	CDD:282045	120/556 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910