DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip75 and TUBGCP4

DIOPT Version :9

Sequence 1:	NP_609412.1	Gene:	Grip75 / 34441	FlyBaseID:	FBgn0026431	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_001273343.1	Gene:	TUBGCP4 / 27229	HGNCID:	16691	Length:	667	Species:	Homo sapiens

Alignment Length:	711	Identity:	202/711 - (28%)
Similarity:	336/711 - (47%)	Gaps:	113/711 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIHDLLLACRSHNPEQLGIKAFNETTVID-----QFIHPCEREIFMDIIKI----IKVYQEVEQF 56
            |||:||||...:..   .|..:|:.:.:.     .|:||.|..:...:.::    |:..:.:||:
Human     1 MIHELLLALSGYPG---SIFTWNKRSGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIEQY 62

  Fly    57 THSSGRKSDTH----GELPDSLHGYYLLNLAKGIEMALEEYYAEIGRLEKYCLGNERNSLSYVYN 117
            | ...::.|.|    |:  ..|||.||.....|::..|:.|...:..||:..||:...|:|:| |
Human    63 T-GHVQQQDHHPSQQGQ--GGLHGIYLRAFCTGLDSVLQPYRQALLDLEQEFLGDPHLSISHV-N 123

  Fly   118 ALYAKFPLLV-FMRNLITEIHVLNLRGCVLLHNLHQQCEHGDIQLEKAIKIIMKPVKNAFFSSLA 181
            ....:|.||. .:..::.:|....:.||.:|..:::....|...:..|::.|:.......:..|:
Human   124 YFLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCHGVMYKQLS 188

  Fly   182 HWLLFGVIDDVHSEFFIKFTPTD-----------------AVDGSSFSKSATCSLLSAEKNPEDY 229
            .|:|.|::.|.|.|||||..|:.                 .:.|....:.....|:..|......
Human   189 AWMLHGLLLDQHEEFFIKQGPSSGNVSAQPEEDEEDLGIGGLTGKQLRELQDLRLIEEENMLAPS 253

  Fly   230 IWQYEVNMSQLPGFFSIVLAEKVLFVGQTVLVFKMGRNVK-------VKNKTDPLAAKLAELDSD 287
            :.|:.:.:..||.:..:.:|||:||||::|.:|: .:||.       :||:.|..||:|..|...
Human   254 LKQFSLRVEILPSYIPVRVAEKILFVGESVQMFE-NQNVNLTRKGSILKNQEDTFAAELHRLKQQ 317

  Fly   288 DIYQLWSGRESEFFKMVVDLSNEDTINVFRLEKVIIDIKNYVSARLSEIAVNEVDLERQMGLIKD 352
            .::.|            ||           .|:|:..|::.|:..|.::.|.|.||..|:.:|||
Human   318 PLFSL------------VD-----------FEQVVDRIRSTVAEHLWKLMVEESDLLGQLKIIKD 359

  Fly   353 FFLLGRGEFYLEF---CSQMVGTMETYREERFKNVTRSFELAATVTGITDD--LDKFSLICQ--- 409
            |:||||||.:..|   ...|:.|..|...|...||  :|:.:|....:.||  |....|..:
Human   360 FYLLGRGELFQAFIDTAQHMLKTPPTAVTEHDVNV--AFQQSAHKVLLDDDNLLPLLHLTIEYHG 422

  Fly   410 ---------------RSTSEPDDTSDFNFLQGLSLKYEYEWPLNLLFSPTTIERYNNIFRFLLII 459
                           |.|| |.:.....: ..|.|.|:.:|||::||:|..:|:||.:|::||.:
Human   423 KEHKADATQAREGPSRETS-PREAPASGW-AALGLSYKVQWPLHILFTPAVLEKYNVVFKYLLSV 485

  Fly   460 RTYQYEIQRVWAKQTWRAKSAKDVPPNNKIITLRNYLMFFLNNMQYYIQVDVLESQFGILMNVIK 524
            |..|.|:|..||.|..| |..|....:.....|||::.|.::|:|||:|||||||||..|::.|.
Human   486 RRVQAELQHCWALQMQR-KHLKSNQTDAIKWRLRNHMAFLVDNLQYYLQVDVLESQFSQLLHQIN 549

  Fly   525 SRSDFEVIQRAHTVFLANVLSHCFLLNESETQLNVTGSQNRNPIYGTLLKLFGICEKFAHM-TQT 588
            |..|||.|:.||..||:|:|:..|:|              ..|::..|.::..:|..|..: :|.
Human   550 STRDFESIRLAHDHFLSNLLAQSFIL--------------LKPVFHCLNEILDLCHSFCSLVSQN 600

  Fly   589 KDPSDDL-EDEVDQLNESFGVQIASLIQLLVDVKSASCLGPLSQLLLRLDFNCWFSASHNT 648
            ..|.|:. ..::..|.:.|..|.:.|.::|..|::......|:|||||||:|.:::.:..|
Human   601 LGPLDERGAAQLSILVKGFSRQSSLLFKILSSVRNHQINSDLAQLLLRLDYNKYYTQAGGT 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip75	NP_609412.1	Spc97_Spc98	25..548	CDD:282045	168/583 (29%)
TUBGCP4	NP_001273343.1	GCP_N_terminal	2..347	CDD:407574	90/375 (24%)
		Spc97_Spc98	350..655	CDD:398000	108/323 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..445		4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159759
Domainoid	1	1.000	146	1.000	Domainoid score	I4560
eggNOG	1	0.900	-	-		E1_KOG2065
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8690
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3389
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58740
OrthoDB	1	1.010	-	-		D1137416at2759
OrthoFinder	1	1.000	-	-		FOG0007435
OrthoInspector	1	1.000	-	-		oto88846
orthoMCL	1	0.900	-	-		OOG6_103557
Panther	1	1.100	-	-	LDO	PTHR19302
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4584
SonicParanoid	1	1.000	-	-		X5566
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800