Protein Alignment Grip75 and alp4

DIOPT Version :10

• Sequence 1: NP_609412.1
• Gene: Grip75 / 34441
• FlyBaseID: FBgn0026431
• Length: 650
• Species: Drosophila melanogaster
• Sequence 2: NP_596044.1
• Gene: alp4 / 2540392
• PomBaseID: SPBC365.15
• Length: 784
• Species: Schizosaccharomyces pombe
• Alignment Length: 729
• Identity: 144/729 - (19%)
• Similarity: 261/729 - (35%)
• Gaps: 211/729 - (28%)

  Fly     6 LLACRSHNPEQLGIKAFNETT------VIDQFIHPCEREIFMDIIKIIKVYQEVEQFTHSSGRKS 64
            :|...||   .|.|.||.|:.      .::..:....|:..||.:.:|...:...:...:...::
pombe   124 MLEMGSH---YLSITAFIESRSHFEYGFVNHALCAALRKFVMDYVVLIMQCENQSRIDPNFSLQT 185

  Fly    65 DTHGELPD--SLHGYYLL----------NLAKGIEMALEEYYAEIGRLEKYCLGNERNSLSYVYN 117
            .....||.  ||...||:          |.:...::.|......:.:|      ||.|.:|:|.|
pombe   186 LRLYTLPTSRSLRQVYLILRDLLLSMEKNASSSDDLGLSNIDDLLEQL------NEGNDISHVVN 244

  Fly   118 ALYAK------FPLLVFMRNLITEIHVLNLRGCVLLHNLHQQCEHGDIQLEKAIKIIMKPVKNAF 176
            |..:|      ..::.|:...:|:.                   .||....|.:..:::.....:
pombe   245 ATRSKKKVCKGGQVISFLTESLTKY-------------------AGDPVARKILTYLLREASRPY 290

  Fly   177 FSSLAHWLLFGVIDDVHSEFFIKFTPTDAVDGSSFSKSATCSLLSAEKNPEDYIWQYEVNMSQLP 241
            ...|..|:..|:::|.:.||.||           ..|..|...|..:...|.:..:|.:...|:|
pombe   291 TKMLNEWIHLGLVNDPYDEFMIK-----------IHKGITSMQLDEDYTDEYWEKRYVIREDQVP 344

  Fly   242 GFFSIVLAEKVLFVGQ---TVLVFKMGRNVKVKNKTDPLAAKLAELDSDDIYQ---LWSGRESEF 300
            ... :.|..||||.|:   .||..:.|.|            .||.|::.|..|   ||   .|.|
pombe   345 PQL-LDLQNKVLFAGKYLNVVLECRKGVN------------NLASLNAKDDTQNQLLW---PSTF 393

  Fly   301 FKMVVDLSNED--TINVFRLEKVIIDIKNYVSARLSEIAVNEVDLERQMGLIKDFFLLGRGEFYL 363
                    ::|  |:|       |::...|.:..|.::..:...|...:..:|.:|.|.:.:|:.
pombe   394 --------DDDNFTLN-------IMNAYVYANESLLQLLQSSQSLYAHLYSLKHYFFLDQSDFFT 443

  Fly   364 EFCSQMVGTMETYREERFKNVTR---SFELA----ATVTG-------ITDDLDKFSLI------- 407
            .|...  ...|..:..::.::|:   ..:||    .|:|.       :|.::::.|||
pombe   444 TFLDN--AQHELRKPAKYISITKLQSQLDLALRQPGTITATDPHKEYVTVEVNQTSLIDWLMHIV 506

  Fly   408 ----------------------------------------CQRSTSEPDDTSDFNFLQGLSLKYE 432
                                                    ..:.||:.....|.|..:.:.|.|:
pombe   507 SISGLEEGTSSQGNEVWNESITKQADVGNETRNFESEHNRSTQGTSKVGSDKDINGFETMQLCYK 571

  Fly   433 YEWPLNLLFSPTTIERYNNIFRFLLIIRTYQYEIQRVWAKQT----WRAKSAKDVPPNNKI---- 489
            ..:||:|:.|...|.||..:||:.|::|..:.:::..|.:.:    ||..|:     |.||
pombe   572 VPFPLSLILSRKAIIRYQLLFRYFLLLRHVEMQLENSWVQHSKNSAWRLNSS-----NAKIEQWK 631

  Fly   490 ---ITLRNYLMFFLNNMQYYIQVDVLESQFGILMNVIKSRSDFEVIQRAHTVFLANVLSHCFLLN 551
               ..||..::.|:..:.||...:|:|:.:|..|..:::....:.:.:.|..||...|..|.|.|
pombe   632 RNSWLLRTRMLSFVQKIIYYTTSEVIETHWGKFMGELENARTVDNLMQEHIDFLDTCLKECMLTN 696

  Fly   552 ESETQLNVTGSQNRNPIYGTLLKLFGICEKFAHMTQTKDPS----------------DDLEDEVD 600
            ....::.              .||...|..||..|.|...|                |.:|:.:.
pombe   697 SRLLKVQ--------------SKLLNTCAMFASYTSTFTRSLYLLENSEESFDEGRMDKMEEILR 747

  Fly   601 QLNESFGVQIASLI 614
            :..:||...:.||:
pombe   748 RYEDSFSRHLKSLV 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grip75	NP_609412.1	GCP_N_terminal	2..340	CDD:465456	74/365 (20%)
		GCP_C_terminal	349..642	CDD:461187	69/354 (19%)
alp4	NP_596044.1	GCP_N_terminal	72..367	CDD:465456	57/282 (20%)
		GCP_C_terminal	425..782	CDD:461187	69/358 (19%)