DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grip75 and Tubgcp5

DIOPT Version :9

Sequence 1:	NP_609412.1	Gene:	Grip75 / 34441	FlyBaseID:	FBgn0026431	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_666302.2	Gene:	Tubgcp5 / 233276	MGIID:	2178836	Length:	1024	Species:	Mus musculus

Alignment Length:	761	Identity:	145/761 - (19%)
Similarity:	276/761 - (36%)	Gaps:	206/761 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VIDQFIHPCEREIFMDIIKIIKVYQEVEQFT-----HSSGRKSDTHGEL----PDSLHGYYLLNL 82
            ::....|.|.|.:...|....:|...:::|.     |||......:|.:    ||:....|
Mouse   301 IVTHLTHSCLRSVLEQIAAYGQVVFRLQEFIDEVMGHSSESLPPGNGPIPKKQPDAPFRTY---- 361

  Fly    83 AKGIEMALEEYY----AEIGRLEKYCLGNERN-SLSYVYNALYAKFPLL-----VF--------- 128
             :....||.:|:    .|:..:||..:.::.. :|:.|.|.|..:...|     ||
Mouse   362 -QAFMWALYKYFINFKEELTDIEKCVISSDTTITLAIVVNKLAPRLAQLKVLDKVFSTGVAEVPP 425

  Fly   129 -MRNLITEIHVLN-LRGCVLLHNLHQQCEHGDIQLEKAIKI-IMKPVKNAFFSSLAHWLLFGVID 190
             .||::...|:|| |...:|.::...:.....:.|..::.: .::|    :..::..|::.|.:.
Mouse   426 DTRNVVRASHLLNTLYKAILEYDNVGEASEQTVSLLFSLWVETVRP----YLQTVDEWIVHGHLW 486

  Fly   191 DVHSEFFIKFTPTDAVDGSSF--------------------SKSATCSLLSAEKNPEDYIWQYEV 235
            |...||.|:......|:...|                    |.||:.| ..:::.|...  |:.:
Mouse   487 DGAREFIIQRNKNVPVNHRDFWYATYTLYSVSEKTENEDKVSDSASAS-SGSDQGPSSR--QHTM 548

  Fly   236 NMSQLPGFFSIVLAEK-----------------------------VLFVGQTVLVFKMG------ 265
            .....|....|::|.|                             .||:....|..:.|
Mouse   549 VSFLKPVLKQIIMAGKSMQLLKNLNCAEGPACQAAARDAERKSLYTLFLESIQLRLQHGEDSAPH 613

  Fly   266 --------------------RNVKVKNKTDP-LAAKLAE--LDSDDIYQLWSGRESEFFKMVVDL 307
                                |::::.:..|| ||...|.  |:..|.::.::|.:     :.||.
Mouse   614 IVNEDQTTKENLIKMQSIAERHLELDDIHDPLLAINFARLYLEQSDFHEKFAGGD-----ICVDR 673

  Fly   308 SNED-TINVFRLE-----KVIIDIKNYV--SARLSEIAVNEVDLERQMGLIKDFFLLGRGEFYLE 364
            |:|. |...|.|.     ...|| |.|:  ...|.:....:..|...:..:::|||:..|:...:
Mouse   674 SSESVTCQTFELTLRSCLYPHID-KQYLHCCGNLMQTLKRDFRLVEYLQAMRNFFLMEGGDTMYD 737

  Fly   365 FCSQM---VGTMETYREERFKNVTRSFELAATV-TGITDDLDKFSLICQRSTSEPDDTS---DFN 422
            |.:.:   :...||::...|.||    :|...| ....:|..:.|:    |....|.|.   ..:
Mouse   738 FYTSIFDKIREKETWQNVSFLNV----QLQEAVGQRYPEDSLRLSI----SFENVDTTKKKLPVH 794

  Fly   423 FLQGLSLKYEYEWPLNLLFSPTTIERYNNIFRFLLIIRTYQYEIQRVWAKQTW------------ 475
            .|.||:|.|:..||::::.|....:.||.:|..||.|:         |||.:.
Mouse   795 ILDGLTLSYKVPWPVDIVISVECQKIYNQVFLLLLQIK---------WAKYSLDVLLFGELGNAA 850

  Fly   476 -RAKSAKDVPPN------------------NKIITLRNYLMFFLNNMQYYIQVDVLESQFGILMN 521
             |:::.:|:|.:                  :::..||..||.|:|::..||...:|.|......:
Mouse   851 ERSQAKEDIPRDQDTPSQFGPPKESLRQQIHRMFLLRVKLMHFVNSLHNYIMTRILHSTGLEFQH 915

  Fly   522 VIKSRSDFEVIQRAHTVFLANVLSHCFLLNESETQLNVTGSQNRNPIYGTLLKLFGICEKFAHMT 586
            .::...|.:.:.:.|..:|:.:...| ||.|..:.           :...::|:..:...||...
Mouse   916 QVEEAKDLDQLIKIHYRYLSTIHDRC-LLREKVSF-----------VKEAIMKVLNLALMFAEGW 968

  Fly   587 QTKDPSDDLEDEVDQLNESFGVQIASLIQLLVDVKSASCLGPLSQL 632
            |....:..:| .::::...|......|:.:|   ..|.|.|....|
Mouse   969 QAGLGAWQME-SIEKMESDFKNCHMFLVTIL---NKAVCRGSFPHL 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip75	NP_609412.1	Spc97_Spc98	25..548	CDD:282045	129/675 (19%)
Tubgcp5	NP_666302.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..203
		Spc97_Spc98	273..942	CDD:282045	130/676 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..545		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	853..873		2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910