DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RluA-2 and rpusd2

DIOPT Version :9

Sequence 1:	NP_001188782.2	Gene:	RluA-2 / 34440	FlyBaseID:	FBgn0032256	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001314846.1	Gene:	rpusd2 / 565088	ZFINID:	ZDB-GENE-120411-43	Length:	579	Species:	Danio rerio

Alignment Length:	580	Identity:	232/580 - (40%)
Similarity:	336/580 - (57%)	Gaps:	60/580 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESSKLLRNAQTQHGDASSVDVENIFLHRHM-LYTNPTSDGNLHDREDSPECVWCPDDKDGSPAE 64
            :::..|||..:.|:.:.    ::.::.:|:: :.|..|....|:.|.:|.:            .|
Zfish    10 IQALTLLRFGRRQNSEF----IKRVYQNRNVSVETQRTHCSVLNVRRNSTQ------------VE 58

  Fly    65 SKDPPISI-----------SEEKSETQSKEVLS-EKRKASSTDD-EGHVKKVKLEANSLKTKRPG 116
            |...|::.           .|...:|.|....| .|||...||: .|.....|.:....|..|||
Zfish    59 SSKHPVNTHLSLYDMDNKGEEGGGDTDSTVKTSCGKRKNEETDEAAGQCSGRKRKRGGGKQLRPG 123

  Fly   117 ---------------FSDERYDETSYYFENGLRKVYPYFFTFTTFAKGRWVDEKILDVFVREFRA 166
                           |:.|.:.|||||||.|||||:||:|.|.::.||||:.:.:||||.:||||
Zfish   124 ERYVPPPQKRNTGVSFNQEHFAETSYYFEGGLRKVHPYYFDFKSYCKGRWIGKTLLDVFKKEFRA 188

  Fly   167 APPEEYERSLEAGKLTVNSEKVPK-DYKIKHNDLLANVVHRHEVPVTSQPIKIVYMDKDIVVVNK 230
            ...:.|..:::.|::.:|...|.. :..:|:||||.|.|||||.||..||:|::..|.::|||:|
Zfish   189 ESLDYYNAAVKEGRIKLNETPVDDLNVVLKNNDLLRNTVHRHEPPVCGQPLKLLVDDGEVVVVDK 253

  Fly   231 PASIPVHPCGRYRHNTVVFILAKEHNLKNLRTIHRLDRLTSGLLLFGRTAEKARELELQIRTRQV 295
            |:|:|||||||||||||:|||.||..|..|.|:|||||||||:|||.||.|.:::|::.:|.||:
Zfish   254 PSSLPVHPCGRYRHNTVIFILGKEKGLVGLHTVHRLDRLTSGVLLFARTLEVSKKLDVMVRERQL 318

  Fly   296 QKEYVCRVEGRFPDGIVECNEKIDVVSYKIGVCKVSPKGKDCKTTFKRIGEVGSDSIVLCKPLTG 360
            :|||||||||.||:..|.|.|.|.|||:::|:|:|.||||:.:|.|:|:...|..|:|.|:||||
Zfish   319 EKEYVCRVEGEFPEAEVVCEEPILVVSFRVGLCRVDPKGKESRTIFQRLSFNGRSSVVRCRPLTG 383

  Fly   361 RMHQIRVHLQFLGYPISNDPLYNHEVFGPLKGRGGDIGGITEEQLISNLISIHNAENWLGLEG-- 423
            |.|||||||||||:||.|||:|....:||.:.:|| :.|:::|:|:..||..|.::..|.|..
Zfish   384 RTHQIRVHLQFLGFPILNDPIYGSSAWGPNRAKGG-LVGMSDEELLEALIEEHRSKESLHLLDLP 447

  Fly   424 DQIVSGEIK----------DVAASTSVVEAPSVVQAPINSETEKPVISKNLEPSNDAT-AQIATQ 477
            |:.|||:.|          .:.|..|...:..|....:.:|:.:.|.....|...:.. |:....
Zfish   448 DEEVSGKTKCKDGAQGRNEQITAIESSSGSSEVSLDEVKAESRQVVQQSTSESVGEINGARKDKD 512

  Fly   478 TCYEEPDRSFDSKKTTSDPQCSECKINYRDPGTKDLIMYLHAWKYKGVGWEYETELPEWA 537
            ...::..|:..||....|..|.||||...||..|:|||||||.:|||..:||.|:||:||
Zfish   513 LASDDASRTGRSKDFVRDHLCGECKIVRPDPTEKELIMYLHALRYKGPDFEYSTQLPDWA 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RluA-2	NP_001188782.2	S4	157..229	CDD:238095	31/72 (43%)
RluA-2	NP_001188782.2	PseudoU_synth_ScRIB2	202..386	CDD:211331	112/183 (61%)
rpusd2	NP_001314846.1	PseudoU_synth_ScRIB2	224..408	CDD:211331	112/183 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592193
Domainoid	1	1.000	202	1.000	Domainoid score	I2945
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5588
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1832
OMA	1	1.010	-	-		QHG51879
OrthoDB	1	1.010	-	-		D504187at33208
OrthoFinder	1	1.000	-	-		FOG0002443
OrthoInspector	1	1.000	-	-		otm26429
orthoMCL	1	0.900	-	-		OOG6_100211
Panther	1	1.100	-	-	O	PTHR21600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1681
SonicParanoid	1	1.000	-	-		X1265
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940