DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RluA-2 and Rpusd2

DIOPT Version :9

Sequence 1:	NP_001188782.2	Gene:	RluA-2 / 34440	FlyBaseID:	FBgn0032256	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001129317.1	Gene:	Rpusd2 / 311326	RGDID:	1306147	Length:	553	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	229/552 - (41%)
Similarity:	323/552 - (58%)	Gaps:	65/552 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ESSKLLRNAQTQHGDASSVDVENIFLHRHMLYTNPTSDGNLHDREDSPECVWCPDDKDGSPAESK 66
            |::..|:....|:||..| |...   ..|:....|.:.|     :..||        .|..|:..
  Rat    44 EAADGLKALIEQNGDTGS-DTRG---EPHLELLEPATVG-----KQVPE--------SGEQAQGG 91

  Fly    67 DPPISISEEKSETQSKEVLSEKRKASSTDDEGHVKKVKLEANSLKTKRPG--FSDERYDETSYYF 129
            :..:..:.|::.|...:....|::..:|.:.        .....|.:|.|  ||||.:.||:|||
  Rat    92 EEQLPGNGEQAPTPVADSGKRKKRRGATGER--------VVPPPKKRRTGVSFSDEHFAETTYYF 148

  Fly   130 ENGLRKVYPYFFTFTTFAKGRWVDEKILDVFVREFRAAPPEEYERSLEAGKLTVNSEKVPKDYKI 194
            |.|||||.||:|.|.|:.|||||...:|.||..|||:.|...||.::.||:|.:|.|.| :|..|
  Rat   149 EGGLRKVRPYYFDFQTYCKGRWVGRSLLHVFSTEFRSQPLAYYEAAVRAGRLHLNEEPV-QDLNI 212

  Fly   195 --KHNDLLANVVHRHEVPVTSQPIKIVYMDKDIVVVNKPASIPVHPCGRYRHNTVVFILAKEHNL 257
              |.||.|.|.|||||.|||::||:::..:.|:||::||:|||||||||:|||||:|||.|||.|
  Rat   213 VLKDNDFLRNTVHRHEPPVTAEPIRLLAENDDVVVIDKPSSIPVHPCGRFRHNTVIFILGKEHQL 277

  Fly   258 KNLRTIHRLDRLTSGLLLFGRTAEKARELELQIRTRQVQKEYVCRVEGRFPDGIVECNEKIDVVS 322
            |.|..:|||||||||:|:|.:||..:.::..|:|.||::|||||||.|.|||..|.|.|.|.|||
  Rat   278 KELHPLHRLDRLTSGVLMFAKTAAVSEKIHEQVRDRQLEKEYVCRVAGEFPDKEVICKEPILVVS 342

  Fly   323 YKIGVCKVSPKGKDCKTTFKRIGEVGSDSIVLCKPLTGRMHQIRVHLQFLGYPISNDPLYNHEVF 387
            ||:|||:|.|:||.|:|.|:|:...|..|:|.|:|||||.|||||||||||:||.|||:||...:
  Rat   343 YKVGVCRVDPQGKPCETVFQRLSYNGRSSVVQCRPLTGRTHQIRVHLQFLGHPILNDPIYNSTAW 407

  Fly   388 GPLKGRGGDIGGITEEQLISNLISIHNAENWLGL----EGDQIVSGEIKDVAAST--------SV 440
            ||.:|:||.|.. |:|:|:.:|::.|.|:..|.:    ||| :..|.|...|.|:        .:
  Rat   408 GPSRGQGGHIPK-TDEELLRDLVAEHQAKESLSMLDLCEGD-LAPGLIDSTAPSSELGKDSLEGL 470

  Fly   441 VEAPSVVQAPINSETEKPVISKNLEPSNDATAQIATQTCYEEPDRSFDSKKTTSDPQCSECKINY 505
            ..|...:...::..::.|.     .|...|.|.::.||                ||.|:||::..
  Rat   471 ATAAQKIDGMVDEASQHPD-----TPGKAAKADVSQQT----------------DPLCAECRVLR 514

  Fly   506 RDPGTKDLIMYLHAWKYKGVGWEYETELPEWA 537
            :||..:||:|:|||.:|||..:||.:.:|.||
  Rat   515 QDPLPQDLVMFLHALRYKGPDFEYVSPIPAWA 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RluA-2	NP_001188782.2	S4	157..229	CDD:238095	35/73 (48%)
RluA-2	NP_001188782.2	PseudoU_synth_ScRIB2	202..386	CDD:211331	114/183 (62%)
Rpusd2	NP_001129317.1	PseudoU_synth_ScRIB2	221..404	CDD:211331	113/182 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350484
Domainoid	1	1.000	210	1.000	Domainoid score	I2724
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1773
OMA	1	1.010	-	-		QHG51879
OrthoDB	1	1.010	-	-		D504187at33208
OrthoFinder	1	1.000	-	-		FOG0002443
OrthoInspector	1	1.000	-	-		otm45856
orthoMCL	1	0.900	-	-		OOG6_100211
Panther	1	1.100	-	-	O	PTHR21600
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1265
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910