DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RluA-2 and Rpusd2

DIOPT Version :9

Sequence 1:	NP_001188782.2	Gene:	RluA-2 / 34440	FlyBaseID:	FBgn0032256	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_775626.1	Gene:	Rpusd2 / 271842	MGIID:	1918066	Length:	553	Species:	Mus musculus

Alignment Length:	503	Identity:	221/503 - (43%)
Similarity:	308/503 - (61%)	Gaps:	46/503 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 GSPAESKDPPISISEEKSETQSKEVLSEKRKASSTD-------DEGHVKKVKLEANSL-----KT 112
            |.|...:..|.::.::..|:..:....|.:..|:.:       |.|..||.:......     |.
Mouse    65 GEPLLERLEPAAVGKQVPESGDQAQGGEGQLPSNGEQTPAPVADSGKRKKRRGATGERVVPPPKK 129

  Fly   113 KRPG--FSDERYDETSYYFENGLRKVYPYFFTFTTFAKGRWVDEKILDVFVREFRAAPPEEYERS 175
            :|.|  ||||.:.||:||||.|||||.||:|.|.|:.|||||...:|.||..|||:.|...||.:
Mouse   130 RRTGVSFSDEHFAETTYYFEGGLRKVRPYYFDFQTYCKGRWVGRSLLHVFSTEFRSQPLSYYEAA 194

  Fly   176 LEAGKLTVNSEKVPKDYKI--KHNDLLANVVHRHEVPVTSQPIKIVYMDKDIVVVNKPASIPVHP 238
            :.||:|.:|.|.| :|..|  |.||.|.|.|||||.|||::||.::..:.|:||::||:||||||
Mouse   195 VRAGRLHLNEEPV-QDLSIVLKDNDFLRNTVHRHEPPVTAEPIHLLAENNDVVVIDKPSSIPVHP 258

  Fly   239 CGRYRHNTVVFILAKEHNLKNLRTIHRLDRLTSGLLLFGRTAEKARELELQIRTRQVQKEYVCRV 303
            |||:|||||:|||.|||.||.|..:|||||||||:|:|.:||..:.::..|:|.||::|||||||
Mouse   259 CGRFRHNTVIFILGKEHQLKELHPLHRLDRLTSGVLMFAKTAAVSEKIHEQVRDRQLEKEYVCRV 323

  Fly   304 EGRFPDGIVECNEKIDVVSYKIGVCKVSPKGKDCKTTFKRIGEVGSDSIVLCKPLTGRMHQIRVH 368
            .|.|||..|.|.|.|.|||||:|||:|.|:||.|:|.|:|:...|..|:|.|:|||||.||||||
Mouse   324 AGEFPDKEVICKEPILVVSYKVGVCRVDPRGKPCETVFQRLSYNGRSSVVQCRPLTGRTHQIRVH 388

  Fly   369 LQFLGYPISNDPLYNHEVFGPLKGRGGDIGGITEEQLISNLISIHNAENWLGL----EGDQIVSG 429
            |||||:||.|||:||...:||.:|:||.|.. |:|:|:.:|::.|.|:..|.:    |.| :..|
Mouse   389 LQFLGHPILNDPIYNSTAWGPSRGQGGHIPK-TDEELLRDLVAEHQAKESLSMLDLCESD-LTPG 451

  Fly   430 EIKDVAASTSV----VEAPSVVQAPINSETEKPVISKNLE-PSNDATAQIATQTCYEEPDRSFDS 489
            .|...|.|:.:    :|..:.....|:...|  ...::|: |...|.|.:..:|
Mouse   452 LIDSTAPSSELAKDSLEGLATAAQKIDGIAE--AAPQHLDTPEKAAKADVTQET----------- 503

  Fly   490 KKTTSDPQCSECKINYRDPGTKDLIMYLHAWKYKGVGWEYETELPEWA 537
                 ||.|:||::..:||..:||:|:|||.:|||..:||.:.:|.||
Mouse   504 -----DPLCAECRVLRQDPLPQDLVMFLHALRYKGPDFEYVSPIPAWA 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RluA-2	NP_001188782.2	S4	157..229	CDD:238095	35/73 (48%)
RluA-2	NP_001188782.2	PseudoU_synth_ScRIB2	202..386	CDD:211331	114/183 (62%)
Rpusd2	NP_775626.1	Rox3	<4..150	CDD:285797	22/84 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..135		10/58 (17%)
		PseudoU_synth_ScRIB2	221..404	CDD:211331	113/182 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846983
Domainoid	1	1.000	210	1.000	Domainoid score	I2814
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5588
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1775
Isobase	1	0.950	-	0	Normalized mean entropy	S1507
OMA	1	1.010	-	-		QHG51879
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002443
OrthoInspector	1	1.000	-	-		otm43773
orthoMCL	1	0.900	-	-		OOG6_100211
Panther	1	1.100	-	-	O	PTHR21600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1681
SonicParanoid	1	1.000	-	-		X1265
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.880