DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RluA-2 and K07E8.7

DIOPT Version :9

Sequence 1:	NP_001188782.2	Gene:	RluA-2 / 34440	FlyBaseID:	FBgn0032256	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_493778.1	Gene:	K07E8.7 / 173456	WormBaseID:	WBGene00019498	Length:	432	Species:	Caenorhabditis elegans

Alignment Length:	478	Identity:	146/478 - (30%)
Similarity:	238/478 - (49%)	Gaps:	53/478 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 AESKDPPISISEEKSETQSKEVLSEKRKASSTDDEGHVKKVKLEANSLKTKRPGFSDERYDETSY 127
            :::.|.|   ..:||...|.:  ::|||.....:...:|:.|.|.   ..|:....:|...:..:
Worm     2 SDTTDVP---ENQKSPKPSGK--ADKRKIEEKPENSSLKRKKFED---PNKKVDPLEELPMKVPF 58

  Fly   128 YFENGLRKVYPYFFTFTTFAKGRWVDEKILDVFVREFRAAPPEEYERSLEAGKLTVNSEKVPK-D 191
            ...:|:|.:.||:..:.|..||||:..|:::||..||.:......:.:.:.|::.||.|::.. |
Worm    59 KIVDGVRHLAPYWACYRTRTKGRWIGRKMVEVFSGEFLSTNRNYAKIACKMGRIYVNGEQMTDVD 123

  Fly   192 YKIKHNDLLANVVHRHEVPVTSQPIKIVYMDKDIVVVNKPASIPVHPCGRYRHNTVVFILAKEHN 256
            |.:::.|.:.:..||||.|:...||:::....|:.||.||.|:|||.||:|..:||:..|.....
Worm   124 YVMRNGDRVEHWAHRHEHPIRDLPIRVISETDDLFVVEKPPSLPVHTCGQYAIHTVLGQLRVNEG 188

  Fly   257 LKNLRTIHRLDRLTSGLLLFGRTAEKARELELQIRTRQVQKEYVCRVEGRFPDGIVECNEKIDVV 321
            ...||.:|||||.|||:|||.:..|...|.:..::..:..|||:|:|:|.|||....|.:.|..:
Worm   189 RTGLRVLHRLDRATSGVLLFAKNYETDLEFKTTLKQGEWSKEYICKVDGVFPDEEQVCEQPIGPL 253

  Fly   322 SYKIGVCKVSPKGKDCKTTFKRIGEVGSDSIVLCKPLTGRMHQIRVHLQFLGYPISNDPLYNHEV 386
            ...:|:..|.|.|||.|:.|:::...|:.|:|.....|||.||||||.||||:||:.|.:||..|
Worm   254 VISMGIQCVRPDGKDAKSRFRKLWSDGTQSVVQVHIETGRTHQIRVHSQFLGHPIAGDQIYNSAV 318

  Fly   387 FGPLKGRGGDIGGITEEQLISNLISIHNAENWLGLEGDQIVSGEIKDVAASTSVV--EAPSVVQA 449
            :||.||:..|.....:| |..::.:.|..|||......:. ...::.:||.|:.:  ||||:
Worm   319 WGPTKGKNADYQKSFDE-LCEDVRNTHKCENWHEKPNPEF-EQRMEHLAADTTPITPEAPSL--- 378

  Fly   450 PINSETEKPVISKNLEPSNDATAQIATQTCYEEPDRSFDSKKTTSDPQCSECKINYRDPGTKDLI 514
                                        |..:.|:         .|..|.:|.:..:........
Worm   379 ----------------------------TLEQRPE---------FDEICQKCNVESKKVPENHFQ 406

  Fly   515 MYLHAWKYKGVGWEYETELPEWA 537
            :|||..||:...|.::||:|:||
Worm   407 LYLHCLKYETKKWSFKTEMPDWA 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RluA-2	NP_001188782.2	S4	157..229	CDD:238095	20/72 (28%)
RluA-2	NP_001188782.2	PseudoU_synth_ScRIB2	202..386	CDD:211331	77/183 (42%)
K07E8.7	NP_493778.1	PseudoU_synth_ScRIB2	134..430	CDD:211331	112/338 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164598
Domainoid	1	1.000	124	1.000	Domainoid score	I3410
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	249	1.000	Inparanoid score	I2013
Isobase	1	0.950	-	0	Normalized mean entropy	S1507
OMA	1	1.010	-	-		QHG51879
OrthoDB	1	1.010	-	-		D504187at33208
OrthoFinder	1	1.000	-	-		FOG0002443
OrthoInspector	1	1.000	-	-		otm14117
orthoMCL	1	0.900	-	-		OOG6_100211
Panther	1	1.100	-	-	O	PTHR21600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1681
SonicParanoid	1	1.000	-	-		X1265
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890