DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RluA-2 and rpusd2

DIOPT Version :9

Sequence 1:	NP_001188782.2	Gene:	RluA-2 / 34440	FlyBaseID:	FBgn0032256	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	XP_002940545.1	Gene:	rpusd2 / 100497757	XenbaseID:	XB-GENE-994596	Length:	497	Species:	Xenopus tropicalis

Alignment Length:	529	Identity:	227/529 - (42%)
Similarity:	320/529 - (60%)	Gaps:	79/529 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SDGNLHDREDSPECVWCPDDKDGSPAESKDPPISISEEKSETQSKEVLSEKRKASSTDDEGHV-- 100
            |:|:|..:|           .:|.|.|.               :.:...:||||:. |.:.||
Frog    23 SEGSLKRKE-----------PNGEPGEG---------------AGKRRHKKRKAAG-DGDRHVPP 60

  Fly   101 ---KKVKLEANSLKTKRPGFSDERYDETSYYFENGLRKVYPYFFTFTTFAKGRWVDEKILDVFVR 162
               :||.:          .|.||.:.||..|.|||||||.||:|.|.|:.|||||.:.:|:||.:
Frog    61 PVKRKVGV----------SFGDEHFRETETYLENGLRKVRPYYFDFETYCKGRWVGKSLLEVFGK 115

  Fly   163 EFRAAPPEEYERSLEAGKLTVNSEKVPKDYKI--KHNDLLANVVHRHEVPVTSQPIKIVYMDKDI 225
            ||||.|.|.||::.:||:|.:|.|.| :|..:  |:||.|.|.|||||.|||::|::|:..:.::
Frog   116 EFRAEPLEYYEQAAQAGRLRLNEETV-RDLNVVLKNNDFLRNTVHRHEPPVTAEPLRILAENDEM 179

  Fly   226 VVVNKPASIPVHPCGRYRHNTVVFILAKEHNLKNLRTIHRLDRLTSGLLLFGRTAEKARELELQI 290
            ||::||:|:|||||||:|||||:|||.||:|||.|.|||||||:|||:|:|.:|.|.:::::.|:
Frog   180 VVIDKPSSLPVHPCGRFRHNTVIFILGKEYNLKGLHTIHRLDRMTSGVLMFAKTLEVSKKIDEQV 244

  Fly   291 RTRQVQKEYVCRVEGRFPDGIVECNEKIDVVSYKIGVCKVSPKGKDCKTTFKRIGEVGSDSIVLC 355
            |.||::|||||||.|.||...|.|.|.|.|||||||||:|.||||.|||.|:|:...|..|:|.|
Frog   245 RQRQLEKEYVCRVCGEFPKEEVTCEEPIFVVSYKIGVCRVDPKGKPCKTVFQRLSYNGKSSVVKC 309

  Fly   356 KPLTGRMHQIRVHLQFLGYPISNDPLYNHEVFGPLKGRGGDIGGITEEQLISNLISIHNAENWLG 420
            .|.|||.||||||||:||:||.|||:||.|.:||.:|:||:|.. |:|.|:..|:.:|.::..|
Frog   310 FPYTGRTHQIRVHLQYLGHPIVNDPIYNTEAWGPNRGKGGEINR-TDEDLLRALVDVHKSKQSL- 372

  Fly   421 LEGDQIVSGEIKDVAASTSVVEAPSVVQAPINSETEKPVISKNLEPSNDATAQIATQTC------ 479
                     :|.|::....   .|.:..|.:.|.|| ||..:..||: |...:...|.|
Frog   373 ---------DILDISEEDL---QPIMENAGLKSSTE-PVQKEASEPA-DPQPKDEAQECKLTENV 423

  Fly   480 ---YEEPDRSF------DSKKTTSDPQCSECKINYRDPGTKDLIMYLHAWKYKGVGWEYETELPE 535
               .::.|.|.      :|.:.:.|..|.||:|...||..|||:|||||.:|||..:::.:::|:
Frog   424 TNSSQDTDSSAACRITEESSQGSRDSLCGECRIVRADPSPKDLVMYLHALRYKGAEFDFSSDMPD 488

  Fly   536 WA---CNSN 541
            ||   |..|
Frog   489 WAQENCQEN 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RluA-2	NP_001188782.2	S4	157..229	CDD:238095	35/73 (48%)
RluA-2	NP_001188782.2	PseudoU_synth_ScRIB2	202..386	CDD:211331	113/183 (62%)
rpusd2	XP_002940545.1	PseudoU_synth_ScRIB2	155..337	CDD:211331	111/181 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3011
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1838
OMA	1	1.010	-	-		QHG51879
OrthoDB	1	1.010	-	-		D504187at33208
OrthoFinder	1	1.000	-	-		FOG0002443
OrthoInspector	1	1.000	-	-		otm48946
Panther	1	1.100	-	-	O	PTHR21600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1681
SonicParanoid	1	1.000	-	-		X1265
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.110