Protein Alignment CDKL4 and CkIIalpha

DIOPT Version :10

• Sequence 1: NP_001333840.1
• Gene: CDKL4 / 344387
• HGNCID: 19287
• Length: 379
• Species: Homo sapiens
• Sequence 2: NP_524918.1
• Gene: CkIIalpha / 48448
• FlyBaseID: FBgn0264492
• Length: 336
• Species: Drosophila melanogaster
• Alignment Length: 309
• Identity: 93/309 - (30%)
• Similarity: 154/309 - (49%)
• Gaps: 45/309 - (14%)

Human     2 EKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLK-HPNLVN 65
            :.|:.:.|.|.|.|..||:..|.|:.:...||..     .||.||...|||::|:.|: ..|::.
  Fly    35 DDYQLVRKLGRGKYSEVFEAINITTTEKCVVKIL-----KPVKKKKIKREIKILENLRGGTNIIT 94

Human    66 LIEVFRR--KRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIK 128
            |:.|.:.  .|...|:||:.::|...:|.:.   :.|..|:..|::.|:||::||....:|||:|
  Fly    95 LLAVVKDPVSRTPALIFEHVNNTDFKQLYQT---LTDYEIRYYLFELLKALDYCHSMGIMHRDVK 156

Human   129 PENILITKQG-IIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFA 192
            |.|::|..:. .:::.|:|.|:...||..|...||:|:::.|||||....|..|:|:|::||:.|
  Fly   157 PHNVMIDHENRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLA 221

Human   193 ELL-TGQPLWPGKSDVDQLYLIIRTLG-------------KLIPRHQSIFKSNG------FFHGI 237
            .:: ..:|.:.|..:.|||..|.:.||             .|.||...|.:.:.      |.|
  Fly   222 SMIFRKEPFFHGHDNYDQLVRIAKVLGTEELYAYLDKYNIDLDPRFHDILQRHSRKRWERFVH-- 284

Human   238 SIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYF 286
                 .|.:.|      |.|.||:|:...|:.:..||||..:.:...||
  Fly   285 -----SDNQHL------VSPEALDFLDKLLRYDHVDRLTAREAMAHPYF 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL4	NP_001333840.1	STKc_CDKL1_4	2..286	CDD:270837	91/307 (30%)
		[NKR]KIAxRE	45..51		2/5 (40%)
CkIIalpha	NP_524918.1	STKc_CK2_alpha	18..322	CDD:271034	91/307 (30%)