Protein Alignment CDKL4 and p38a

DIOPT Version :10

• Sequence 1: NP_001333840.1
• Gene: CDKL4 / 344387
• HGNCID: 19287
• Length: 379
• Species: Homo sapiens
• Sequence 2: NP_477163.1
• Gene: p38a / 42866
• FlyBaseID: FBgn0015765
• Length: 366
• Species: Drosophila melanogaster
• Alignment Length: 308
• Identity: 93/308 - (30%)
• Similarity: 164/308 - (53%)
• Gaps: 25/308 - (8%)

Human     4 YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVNLIE 68
            |:.|...|.|:||.|.|...:.:...||:||........|..|...||:|:||.:.|.|::.|::
  Fly    25 YQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLD 89

Human    69 VF---------RRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIH 124
            :|         ...::::||....|..|.|.:..  ..::|..::.:::|.|:.|.:.|....||
  Fly    90 IFHPHPANGSLENFQQVYLVTHLMDADLNNIIRM--QHLSDDHVQFLVYQILRGLKYIHSAGVIH 152

Human   125 RDIKPENILITKQGIIKICDFGFAQILIPGD-AYTDYVATRWYRAPELLVGDTQYGSSVDIWAIG 188
            ||:||.||.:.:...::|.|||.|:   |.: ..|.|||||||||||:::....|..:||||::|
  Fly   153 RDLKPSNIAVNEDCELRILDFGLAR---PTENEMTGYVATRWYRAPEIMLNWMHYDQTVDIWSVG 214

Human   189 CVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFK-----SNGFFHGISIPEPEDMETL 248
            |:.|||:|.:.|:||...:.||.||:..||  .|..:.:.|     :..:..  |:| |....:.
  Fly   215 CIMAELITRRTLFPGTDHIHQLNLIMEMLG--TPPAEFLKKISSESARSYIQ--SLP-PMKGRSF 274

Human   249 EEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIKR 296
            :..|.:.:|:|::.::..|:::.:.|:|..:.|...|.:.:.|..:::
  Fly   275 KNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYLEKYAEPSVEQ 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL4	NP_001333840.1	STKc_CDKL1_4	2..286	CDD:270837	91/296 (31%)
		[NKR]KIAxRE	45..51		1/5 (20%)
p38a	NP_477163.1	STKc_p38	9..354	CDD:143356	93/308 (30%)