Protein Alignment CDKL4 and CG6800

DIOPT Version :10

• Sequence 1: NP_001333840.1
• Gene: CDKL4 / 344387
• HGNCID: 19287
• Length: 379
• Species: Homo sapiens
• Sequence 2: NP_650984.1
• Gene: CG6800 / 42562
• FlyBaseID: FBgn0038902
• Length: 302
• Species: Drosophila melanogaster
• Alignment Length: 293
• Identity: 102/293 - (34%)
• Similarity: 158/293 - (53%)
• Gaps: 19/293 - (6%)

Human     3 KYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVNLI 67
            :|:.|.|.|||.:|.|||..:....:.||:||.........:....||||:.|:..|...::::|
  Fly     8 RYKMLEKIGEGVHGCVFKAIDLQRNKEVAIKKVALKNKFGNIALNTLREIKTLQLCKSEYILDII 72

Human    68 EVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENI 132
            :::.....:.||.||...||.|.|:...|.::...::....|..:.:.:.|....:||||||.|:
  Fly    73 DIYPDLTGLSLVLEYQPDTLYNRLKSEVNPLSRQQVRKFAHQMFKGIAYLHEAGLMHRDIKPANL 137

Human   133 LITKQGIIKICDFGFAQILIPGD---AYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAEL 194
            ||:...::||.|||.|::..|.|   .|:..|:||||||||:|.|..:||:.||:||.|||.||:
  Fly   138 LISDTDMLKIADFGLARLYFPEDESRLYSPQVSTRWYRAPEILFGSQKYGTGVDMWAAGCVVAEM 202

Human   195 LTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIPE------PEDMETLEEKF- 252
            |.|.||:.|.:|::||.:||||||.  ||      .|.:....|:|:      |..:....:..
  Fly   203 LRGVPLFAGTTDIEQLAIIIRTLGS--PR------LNQWPELTSLPDYSKIRFPNSVGIHWDNLF 259

Human   253 -SDVHPVALNFMKGCLKMNPDDRLTCSQLLESS 284
             |..|.|.:|.:...:..||.:||..|::..:|
  Fly   260 PSCTHAVEINLVSNLVVYNPKNRLKASEVGSAS 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL4	NP_001333840.1	STKc_CDKL1_4	2..286	CDD:270837	102/293 (35%)
		[NKR]KIAxRE	45..51		1/5 (20%)
CG6800	NP_650984.1	STKc_CCRK	8..295	CDD:270826	102/293 (35%)