Protein Alignment CDKL4 and Cdk12

DIOPT Version :10

• Sequence 1: NP_001333840.1
• Gene: CDKL4 / 344387
• HGNCID: 19287
• Length: 379
• Species: Homo sapiens
• Sequence 2: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Alignment Length: 361
• Identity: 123/361 - (34%)
• Similarity: 185/361 - (51%)
• Gaps: 47/361 - (13%)

Human     1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKF---VESEDDPVVKKIALREIRMLKQLKHPN 62
            ::.:|.:|:.|||:||.|:|.|:..:..:||:||.   .|.|..|:.   |:|||::|:||.|.|
  Fly   801 VDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPIT---AVREIKILRQLNHRN 862

Human    63 LVNLIEV---------FRR-KRKMHLVFEYCDHTLLNELERNPNGVADGVIK---SVLWQTLQAL 114
            :|||.|:         ||: |...:|||||.||.|:..||   :|:.|...:   |::.|.|..|
  Fly   863 IVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLE---SGMVDFNEENNASIMKQLLDGL 924

Human   115 NFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGD---AYTDYVATRWYRAPELLVGDT 176
            |:||..|.:|||||..|||:..:|.:|:.|||.|::....|   .||:.|.|.|||.||||:|:.
  Fly   925 NYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEE 989

Human   177 QYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIPE 241
            :||.|:|:|:.||:..||...:||:...:::.||..|.:..|..:|...........||.:. .:
  Fly   990 RYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLK-QK 1053

Human   242 PEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYF-----DSFQEAQI------- 294
            ......|.|.|..:...||:.:...|.::||.|:|....|.|.:.     |.....|:
  Fly  1054 KTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCH 1118

Human   295 ---KRKARNEGRNRRRQQQAPKSAFPRLFLKTKICQ 327
               .:|.|   |..|.||:   |..|.:...||..|
  Fly  1119 ELWSKKRR---RQMREQQE---SLPPTVIASTKYQQ 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL4	NP_001333840.1	STKc_CDKL1_4	2..286	CDD:270837	110/302 (36%)
		[NKR]KIAxRE	45..51		1/5 (20%)
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	110/303 (36%)