Protein Alignment CDKL4 and Pitslre

DIOPT Version :10

• Sequence 1: NP_001333840.1
• Gene: CDKL4 / 344387
• HGNCID: 19287
• Length: 379
• Species: Homo sapiens
• Sequence 2: NP_649251.2
• Gene: Pitslre / 40292
• FlyBaseID: FBgn0016696
• Length: 952
• Species: Drosophila melanogaster
• Alignment Length: 351
• Identity: 108/351 - (30%)
• Similarity: 188/351 - (53%)
• Gaps: 43/351 - (12%)

Human     1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKF---VESEDDPVVKKIALREIRMLKQLKHPN 62
            :|:::.|.:..||:||||::.::|.:.::||:|:.   .|.|..|:.   :||||..|.:.:|||
  Fly   555 VEEFQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPIT---SLREINTLLKGQHPN 616

Human    63 LVNLIEVF--RRKRKMHLVFEYCDH---TLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNC 122
            :|.:.|:.  ....|:.:|.:|.:|   :|:..::........|.:|.:..|.|:|:...|.:..
  Fly   617 IVTVREIVVGSNMDKIFIVMDYVEHDLKSLMETMKNRKQSFFPGEVKCLTQQLLRAVAHLHDNWI 681

Human   123 IHRDIKPENILITKQGIIKICDFGFA-QILIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWA 186
            :|||:|..|:|::.:||:|:.|||.| :...|...||..|.|.||||||||:....|.:.:|:|:
  Fly   682 LHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWS 746

Human   187 IGCVFAELLTGQPLWPGKSDVDQLYLIIRTLG----KL------IPRHQSIFKSNGFFHGISIPE 241
            :||:|||.|...||:||||::|:|..|.:.||    |:      :|..:::...|..|  ...|.
  Fly   747 VGCIFAEFLQMLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQF--TEYPV 809

Human   242 PEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQI--------KRKA 298
            .:..:..:||.|:   :.|:.::|.|..:|..||:....|:..:   |:|..:        ...|
  Fly   810 SQLRKHFQEKTSE---MGLSLLQGLLTYDPKQRLSADAALKHGF---FKELPLPIDPSMFPTWPA 868

Human   299 RNEGRNRRRQQQAPK-----SAFPRL 319
            ::|...|:.|..:||     |.|.:|
  Fly   869 KSELGARKAQASSPKPPSGGSQFKQL 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL4	NP_001333840.1	STKc_CDKL1_4	2..286	CDD:270837	97/302 (32%)
		[NKR]KIAxRE	45..51		1/5 (20%)
Pitslre	NP_649251.2	STKc_CDC2L1	552..851	CDD:173741	97/306 (32%)