Protein Alignment CDKL4 and p38b

DIOPT Version :10

• Sequence 1: NP_001333840.1
• Gene: CDKL4 / 344387
• HGNCID: 19287
• Length: 379
• Species: Homo sapiens
• Sequence 2: NP_477361.1
• Gene: p38b / 34780
• FlyBaseID: FBgn0024846
• Length: 365
• Species: Drosophila melanogaster
• Alignment Length: 302
• Identity: 97/302 - (32%)
• Similarity: 161/302 - (53%)
• Gaps: 19/302 - (6%)

Human     2 EKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVNL 66
            |.|:.|...|:|:||.|.|...:.:...||:||........|..|...||:|:||.:.|.|::.|
  Fly    22 ETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGL 86

Human    67 IEVFR---------RKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNC 122
            ::||.         :.:::::|....|..|.|.:....  ::|..::.:::|.|:.|.:.|....
  Fly    87 LDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRTQK--LSDDHVQFLVYQILRGLKYIHSAGV 149

Human   123 IHRDIKPENILITKQGIIKICDFGFAQILIPGDA-YTDYVATRWYRAPELLVGDTQYGSSVDIWA 186
            ||||:||.||.:.:...::|.|||.|:   |.:: .|.|||||||||||:::....|..:.|||:
  Fly   150 IHRDLKPSNIAVNEDCELRILDFGLAR---PAESEMTGYVATRWYRAPEIMLNWMHYNQTADIWS 211

Human   187 IGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGI-SIP-EPEDMETLE 249
            :||:.||||||:.|:||...:.||.||:..||.......|...|....:.| |:| .|.  ....
  Fly   212 VGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARNYIRSLPVMPR--RNFR 274

Human   250 EKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQE 291
            :.|...:|:|::.::..|:::.|.|:|..|.|...|.:.:.:
  Fly   275 DIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYHD 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL4	NP_001333840.1	STKc_CDKL1_4	2..286	CDD:270837	96/295 (33%)
		[NKR]KIAxRE	45..51		1/5 (20%)
p38b	NP_477361.1	STKc_p38	8..353	CDD:143356	97/302 (32%)