Protein Alignment CDKL4 and Pk34A

DIOPT Version :10

• Sequence 1: NP_001333840.1
• Gene: CDKL4 / 344387
• HGNCID: 19287
• Length: 379
• Species: Homo sapiens
• Sequence 2: NP_609603.1
• Gene: Pk34A / 34705
• FlyBaseID: FBgn0028410
• Length: 392
• Species: Drosophila melanogaster
• Alignment Length: 235
• Identity: 84/235 - (35%)
• Similarity: 121/235 - (51%)
• Gaps: 47/235 - (20%)

Human    11 GEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLK-HPNLVNLIEVFRRKR 74
            |.||:|.|::.....|.::||||:.:.:      .|::..|..::.||| |.|:|.||
  Fly    51 GSGSFGRVYQAHVNESEEIVAVKQTLYN------PKLSQGEAEIMGQLKDHNNIVRLI------- 102

Human    75 KMH--------------LVFEYCDHTLLNEL----------ERNPNGVADGVIKSVLWQTLQALN 115
             ||              ||.||...|||:.:          ||..|      ::.:.:|..:.|.
  Fly   103 -MHSSVSLGFPSVDYVLLVMEYMPMTLLDYINYHLTVLQPAERLIN------VRILSYQMFRGLG 160

Human   116 FCHIHNCIHRDIKPENILITKQG-IIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYG 179
            :.|:....|||:||||:||..|. ::|:.|||.|::|:|.:....|:.:|.||||||..|...|.
  Fly   161 YLHLLGISHRDVKPENLLIDNQKMVLKLSDFGSAKLLVPQEPSISYICSRLYRAPELFAGYELYS 225

Human   180 SSVDIWAIGCVFAELLTGQPLWPG-KSDVDQLYLIIRTLG 218
            .:||||:.|||.||||.|.||:.. |.|..||.||:..||
  Fly   226 CAVDIWSAGCVLAELLKGYPLFSSHKHDRKQLRLIVNMLG 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL4	NP_001333840.1	STKc_CDKL1_4	2..286	CDD:270837	84/235 (36%)
		[NKR]KIAxRE	45..51		1/5 (20%)
Pk34A	NP_609603.1	STKc_GSK3	39..334	CDD:271039	84/235 (36%)