Protein Alignment CDKL4 and Cdk1

DIOPT Version :10

• Sequence 1: NP_001333840.1
• Gene: CDKL4 / 344387
• HGNCID: 19287
• Length: 379
• Species: Homo sapiens
• Sequence 2: NP_476797.1
• Gene: Cdk1 / 34411
• FlyBaseID: FBgn0004106
• Length: 297
• Species: Drosophila melanogaster
• Alignment Length: 305
• Identity: 111/305 - (36%)
• Similarity: 179/305 - (58%)
• Gaps: 19/305 - (6%)

Human     1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVN 65
            ||.:||:.|.|||:||||:|.||:.:||:||:||.....||..|...|:|||.:||:|||.|:|.
  Fly     1 MEDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVC 65

Human    66 LIEVFRRKRKMHLVFEYCDHTLLNELERNP--NGVADGVIKSVLWQTLQALNFCHIHNCIHRDIK 128
            |.:|...:.:::|:||:....|...::..|  ..:...:::|.|:|...|:.|||....:|||:|
  Fly    66 LEDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLK 130

Human   129 PENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFA 192
            |:|:||.|.|:||:.|||..:.. ||...||..:.|.||||||:|:|..:|...||||:|||:||
  Fly   131 PQNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFA 195

Human   193 ELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGI-SIPEPED------METLEE 250
            |:.|.:||:.|.|::|||:.:.|.|..         .:...:.|: |:|:.::      ...|..
  Fly   196 EMATRKPLFQGDSEIDQLFRMFRILKT---------PTEDIWPGVTSLPDYKNTFPCWSTNQLTN 251

Human   251 KFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIK 295
            :..::....::.::..|..:|..|::...:||..||:.||...::
  Fly   252 QLKNLDANGIDLIQKMLIYDPVHRISAKDILEHPYFNGFQSGLVR 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL4	NP_001333840.1	STKc_CDKL1_4	2..286	CDD:270837	106/293 (36%)
		[NKR]KIAxRE	45..51		1/5 (20%)
Cdk1	NP_476797.1	STKc_CDK1_euk	3..287	CDD:270845	105/292 (36%)