Protein Alignment CDKL4 and Cdk7

DIOPT Version :10

• Sequence 1: NP_001333840.1
• Gene: CDKL4 / 344387
• HGNCID: 19287
• Length: 379
• Species: Homo sapiens
• Sequence 2: NP_511044.1
• Gene: Cdk7 / 31441
• FlyBaseID: FBgn0263237
• Length: 353
• Species: Drosophila melanogaster
• Alignment Length: 352
• Identity: 120/352 - (34%)
• Similarity: 184/352 - (52%)
• Gaps: 33/352 - (9%)

Human     2 EKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPV---VKKIALREIRMLKQLKHPNL 63
            |:|.||:..|||.:..|:|.|:..:.|:|||||..:...:..   :.:.|||||::|::|:|.|:
  Fly    10 ERYAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENI 74

Human    64 VNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIK 128
            :.|::||.:...:.|||::.|..|...::.|...:....||:....||:.|.:.|::..:|||:|
  Fly    75 IGLVDVFGQLSNVSLVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDLK 139

Human   129 PENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFA 192
            |.|:|:...||:||.|||.|:.. .|...||.:|.|||||:||||.|..|||:.||:||:||:.|
  Fly   140 PNNLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILA 204

Human   193 ELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQS---IFKSNGFFHGISIPEPEDMETLEEKFSD 254
            ||:...|..||.||:|||..|..|||  .|....   :.|.:.:....:.|.    ..|:..|:.
  Fly   205 ELMLRVPFMPGDSDLDQLTRIFSTLG--TPTEAEWPHLSKLHDYLQFRNFPG----TPLDNIFTA 263

Human   255 VHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIKRK--------ARNEGRNRRRQQQA 311
            .....::.|:....|||..|::|.:.|...||.:.....:..|        |..||.|
  Fly   264 AGNDLIHLMQRLFAMNPLRRVSCREALSMPYFANKPAPTVGPKLPMPSAILAAKEGAN------- 321

Human   312 PKSAFPRLFLKTKICQVQRNETQTSGN 338
            |::...:..||.|:.     ||...||
  Fly   322 PQTGDTKPALKRKLV-----ETTVRGN 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL4	NP_001333840.1	STKc_CDKL1_4	2..286	CDD:270837	105/290 (36%)
		[NKR]KIAxRE	45..51		2/5 (40%)
Cdk7	NP_511044.1	STKc_CDK7	11..308	CDD:270833	107/302 (35%)