DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RluA-1 and PUS6

DIOPT Version :9

Sequence 1:	NP_723592.1	Gene:	RluA-1 / 34438	FlyBaseID:	FBgn0051719	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_011685.3	Gene:	PUS6 / 853079	SGDID:	S000003401	Length:	404	Species:	Saccharomyces cerevisiae

Alignment Length:	496	Identity:	134/496 - (27%)
Similarity:	213/496 - (42%)	Gaps:	155/496 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 YMENGLRKVYPYYFTFTTFTKGRWVGEKILDIFSREFRAHPAEEYERCIQTGTLTVNFEKVPI-- 351
            |.:||||||.|||...:.|.||||:|:.::|:...||:..|...|...|:.||..:..:.||:
Yeast    10 YTQNGLRKVRPYYNRRSAFVKGRWLGKLLIDVLVSEFKLRPRAYYLDQIRKGTYRLIRDGVPLVP 74

  Fly   352 DYR----LKHNDLLANIVHRHEVPVT--CQP-------------IKIVHMDEDIVVVNKPASIPV 397
            |:.    :|::|:|....|:||.||.  |..             ..||..||.|:|::||:.|||
Yeast    75 DHLMTTIIKNHDVLETTTHKHEPPVKQWCSQEVEAEDLPGRIAGFNIVFEDESILVIDKPSGIPV 139

  Fly   398 HPCGRYRHNTVVFILAKEFNLKNLRTI--HRLDRLTSGLLLFGRSPKKARQMEQQIRNRQVEKEY 460
            ||.|::..||:..:|    .|..:..:  :|||::|||||:..::.:.|.::::.||:|.:.|.|
Yeast   140 HPTGQFYQNTITELL----KLHGVDALPCYRLDKITSGLLILAKNSQSAGEIQKSIRSRDMIKIY 200

  Fly   461 ICRVEGVFPDG--IVECKEPIEVV---------------------SYKIGVCKVSAKGKDCTTTF 502
            :.||:|.||..  |::.:...|..                     .:.:|:    :..||..|.|
Yeast   201 LARVKGRFPHSELILDNENAAETTFEDTSKVTVEMTPIYSIDPKRQFPVGL----STSKDAITKF 261

  Fly   503 QKLS--QNGTTSVVLCKPLTGRMHQIRVHLQYLGYPILNDPLY-NHEVFGPLKGRSGDIGGKSDE 564
            ..:.  .:...:||.|||:|||.||||:||..||:||:||.:| :|....|
Yeast   262 YPIRYFSHADETVVACKPITGRTHQIRIHLARLGHPIVNDSVYCSHITKYP-------------- 312

  Fly   565 ELIRDLINIHNAENWLGIDCDSDISMFKSTKDEADRESLSSEHTSVVHHSDDDGCVNSRETTPPC 629
            |.::.:......||...:|.:.....|:...||.
Yeast   313 ERLKFITQFPRWENQQDLDAEELKVRFQKFVDET------------------------------- 346

  Fly   630 NEPQQPENSVKLLETTNAVKEYQVAAQKSSSEICPAPLDAVESPLNGGGCNVGKVTVDEHCYEC- 693
                  :|:.:.:||                 .||                           ||
Yeast   347 ------KNNCRTMET-----------------FCP---------------------------ECH 361

  Fly   694 KVHYRDPKSKDLIMYLHAWKYK--GPGWEYETELPNWARND 732
            .|..:||...||.::||||||:  ...::::|:||.||:.|
Yeast   362 TVDLKDPVLSDLELWLHAWKYEEINGKFKFKTDLPKWAQLD 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RluA-1	NP_723592.1	Auts2	21..>162	CDD:291981
RluA-1	NP_723592.1	PseudoU_synth_ScRIB2	363..547	CDD:211331	72/226 (32%)
PUS6	NP_011685.3	PseudoU_synth_ScRIB2	104..400	CDD:211331	96/398 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51879
OrthoFinder	1	1.000	-	-		FOG0002443
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100211
Panther	1	1.100	-	-	O	PTHR21600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1681
SonicParanoid	1	1.000	-	-		X1265
TreeFam	1	0.960	-	-
	9	8.810