DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RluA-1 and rpusd2

DIOPT Version :9

Sequence 1:	NP_723592.1	Gene:	RluA-1 / 34438	FlyBaseID:	FBgn0051719	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001314846.1	Gene:	rpusd2 / 565088	ZFINID:	ZDB-GENE-120411-43	Length:	579	Species:	Danio rerio

Alignment Length:	507	Identity:	223/507 - (43%)
Similarity:	308/507 - (60%)	Gaps:	46/507 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 KRKTDDNDQIK-ELKKAKLETKALKAKRPG---------------FTDERYQETSYYMENGLRKV 297
            |||.::.|:.. :....|.:....|..|||               |..|.:.|||||.|.|||||
Zfish    94 KRKNEETDEAAGQCSGRKRKRGGGKQLRPGERYVPPPQKRNTGVSFNQEHFAETSYYFEGGLRKV 158

  Fly   298 YPYYFTFTTFTKGRWVGEKILDIFSREFRAHPAEEYERCIQTGTLTVNFEKVPID---YRLKHND 359
            :||||.|.::.||||:|:.:||:|.:||||...:.|...::.|.:.:|  :.|:|   ..||:||
Zfish   159 HPYYFDFKSYCKGRWIGKTLLDVFKKEFRAESLDYYNAAVKEGRIKLN--ETPVDDLNVVLKNND 221

  Fly   360 LLANIVHRHEVPVTCQPIKIVHMDEDIVVVNKPASIPVHPCGRYRHNTVVFILAKEFNLKNLRTI 424
            ||.|.|||||.||..||:|::..|.::|||:||:|:|||||||||||||:|||.||..|..|.|:
Zfish   222 LLRNTVHRHEPPVCGQPLKLLVDDGEVVVVDKPSSLPVHPCGRYRHNTVIFILGKEKGLVGLHTV 286

  Fly   425 HRLDRLTSGLLLFGRSPKKARQMEQQIRNRQVEKEYICRVEGVFPDGIVECKEPIEVVSYKIGVC 489
            |||||||||:|||.|:.:.:::::..:|.||:||||:|||||.||:..|.|:|||.|||:::|:|
Zfish   287 HRLDRLTSGVLLFARTLEVSKKLDVMVRERQLEKEYVCRVEGEFPEAEVVCEEPILVVSFRVGLC 351

  Fly   490 KVSAKGKDCTTTFQKLSQNGTTSVVLCKPLTGRMHQIRVHLQYLGYPILNDPLYNHEVFGPLKGR 554
            :|..|||:..|.||:||.||.:|||.|:|||||.||||||||:||:||||||:|....:||.:.:
Zfish   352 RVDPKGKESRTIFQRLSFNGRSSVVRCRPLTGRTHQIRVHLQFLGFPILNDPIYGSSAWGPNRAK 416

  Fly   555 SGDIGGKSDEELIRDLINIHNAENWLG-IDC-DSDISMFKSTKDEADRESLSSEHTSVVHHSDDD 617
            .| :.|.|||||:..||..|.::..|. :|. |.::|.....||.|...   :|..:.:..|...
Zfish   417 GG-LVGMSDEELLEALIEEHRSKESLHLLDLPDEEVSGKTKCKDGAQGR---NEQITAIESSSGS 477

  Fly   618 GCVNSRETTPPCNEPQQPENSVKLLETTNAVKEYQVAAQKSSSEICPAPLDAVESPLNGGGCNVG 682
            ..|:..|......:..|...|..:.|...|.|:..:|:..:|.                  ....
Zfish   478 SEVSLDEVKAESRQVVQQSTSESVGEINGARKDKDLASDDASR------------------TGRS 524

  Fly   683 KVTVDEH-CYECKVHYRDPKSKDLIMYLHAWKYKGPGWEYETELPNWARNDW 733
            |..|.:| |.|||:...||..|:|||||||.:||||.:||.|:||:||:.||
Zfish   525 KDFVRDHLCGECKIVRPDPTEKELIMYLHALRYKGPDFEYSTQLPDWAKEDW 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RluA-1	NP_723592.1	Auts2	21..>162	CDD:291981
RluA-1	NP_723592.1	PseudoU_synth_ScRIB2	363..547	CDD:211331	113/183 (62%)
rpusd2	NP_001314846.1	PseudoU_synth_ScRIB2	224..408	CDD:211331	113/183 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592192
Domainoid	1	1.000	202	1.000	Domainoid score	I2945
eggNOG	1	0.900	-	-		E1_COG0564
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1832
OMA	1	1.010	-	-		QHG51879
OrthoDB	1	1.010	-	-		D504187at33208
OrthoFinder	1	1.000	-	-		FOG0002443
OrthoInspector	1	1.000	-	-		otm26429
orthoMCL	1	0.900	-	-		OOG6_100211
Panther	1	1.100	-	-	LDO	PTHR21600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1681
SonicParanoid	1	1.000	-	-		X1265
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800