DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RluA-1 and RluA-2

DIOPT Version :9

Sequence 1:	NP_723592.1	Gene:	RluA-1 / 34438	FlyBaseID:	FBgn0051719	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001188782.2	Gene:	RluA-2 / 34440	FlyBaseID:	FBgn0032256	Length:	547	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	327/519 - (63%)
Similarity:	377/519 - (72%)	Gaps:	47/519 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 KTTSPRDSENLKIKV-------------PEKRKTDDNDQIKELKKAKLETKALKAKRPGFTDERY 283
            |..||.:|::..|.:             .||||....|....:||.|||..:||.|||||:||||
  Fly    58 KDGSPAESKDPPISISEEKSETQSKEVLSEKRKASSTDDEGHVKKVKLEANSLKTKRPGFSDERY 122

  Fly   284 QETSYYMENGLRKVYPYYFTFTTFTKGRWVGEKILDIFSREFRAHPAEEYERCIQTGTLTVNFEK 348
            .|||||.||||||||||:||||||.|||||.|||||:|.|||||.|.|||||.::.|.||||.||
  Fly   123 DETSYYFENGLRKVYPYFFTFTTFAKGRWVDEKILDVFVREFRAAPPEEYERSLEAGKLTVNSEK 187

  Fly   349 VPIDYRLKHNDLLANIVHRHEVPVTCQPIKIVHMDEDIVVVNKPASIPVHPCGRYRHNTVVFILA 413
            ||.||::||||||||:|||||||||.||||||:||:|||||||||||||||||||||||||||||
  Fly   188 VPKDYKIKHNDLLANVVHRHEVPVTSQPIKIVYMDKDIVVVNKPASIPVHPCGRYRHNTVVFILA 252

  Fly   414 KEFNLKNLRTIHRLDRLTSGLLLFGRSPKKARQMEQQIRNRQVEKEYICRVEGVFPDGIVECKEP 478
            ||.|||||||||||||||||||||||:.:|||::|.|||.|||:|||:|||||.||||||||.|.
  Fly   253 KEHNLKNLRTIHRLDRLTSGLLLFGRTAEKARELELQIRTRQVQKEYVCRVEGRFPDGIVECNEK 317

  Fly   479 IEVVSYKIGVCKVSAKGKDCTTTFQKLSQNGTTSVVLCKPLTGRMHQIRVHLQYLGYPILNDPLY 543
            |:||||||||||||.|||||.|||:::.:.|:.|:||||||||||||||||||:|||||.|||||
  Fly   318 IDVVSYKIGVCKVSPKGKDCKTTFKRIGEVGSDSIVLCKPLTGRMHQIRVHLQFLGYPISNDPLY 382

  Fly   544 NHEVFGPLKGRSGDIGGKSDEELIRDLINIHNAENWLGIDCDSDISMFKSTKDEADRESLSSEHT 608
            |||||||||||.|||||.::|:||.:||:|||||||||::.|..:|  ...||.|...|: .|..
  Fly   383 NHEVFGPLKGRGGDIGGITEEQLISNLISIHNAENWLGLEGDQIVS--GEIKDVAASTSV-VEAP 444

  Fly   609 SVVHHSDDDGCVNSRETTPPCNEPQQPENSVKLLETTNAVKEYQVAAQKSSSEICPAPLDAVESP 673
            |||     ...:||....|..::..:|.|....          |:|.|....|    |..:.:|.
  Fly   445 SVV-----QAPINSETEKPVISKNLEPSNDATA----------QIATQTCYEE----PDRSFDSK 490

  Fly   674 LNGGGCNVGKVTVDEHCYECKVHYRDPKSKDLIMYLHAWKYKGPGWEYETELPNWARN---DWD 734
                     |.|.|..|.|||::||||.:||||||||||||||.|||||||||.||.|   |:|
  Fly   491 ---------KTTSDPQCSECKINYRDPGTKDLIMYLHAWKYKGVGWEYETELPEWACNSNIDYD 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RluA-1	NP_723592.1	Auts2	21..>162	CDD:291981
RluA-1	NP_723592.1	PseudoU_synth_ScRIB2	363..547	CDD:211331	152/183 (83%)
RluA-2	NP_001188782.2	S4	157..229	CDD:238095	54/71 (76%)
RluA-2	NP_001188782.2	PseudoU_synth_ScRIB2	202..386	CDD:211331	152/183 (83%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464140
Domainoid	1	1.000	132	1.000	Domainoid score	I1667
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	268	1.000	Inparanoid score	I932
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D504187at33208
OrthoFinder	1	1.000	-	-		FOG0002443
OrthoInspector	1	1.000	-	-		otm26429
orthoMCL	1	0.900	-	-		OOG6_100211
Panther	1	1.100	-	-	P	PTHR21600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1681
SonicParanoid	1	1.000	-	-		X1265
	11	10.930