DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RluA-1 and Rpusd2

DIOPT Version :9

Sequence 1:	NP_723592.1	Gene:	RluA-1 / 34438	FlyBaseID:	FBgn0051719	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001129317.1	Gene:	Rpusd2 / 311326	RGDID:	1306147	Length:	553	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	234/551 - (42%)
Similarity:	324/551 - (58%)	Gaps:	78/551 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 PHQELNHLSSINLNLLRSPAPPLPAIQVLP----SAEVPI----NKKTTSPRDSENLKIKVPEKR 250
            ||.||...:::...:..|........:.||    .|..|:    .:|.......|.: :..|:||
  Rat    67 PHLELLEPATVGKQVPESGEQAQGGEEQLPGNGEQAPTPVADSGKRKKRRGATGERV-VPPPKKR 130

  Fly   251 KTDDNDQIKELKKAKLETKALKAKRPGFTDERYQETSYYMENGLRKVYPYYFTFTTFTKGRWVGE 315
            :|.                      ..|:||.:.||:||.|.|||||.||||.|.|:.||||||.
  Rat   131 RTG----------------------VSFSDEHFAETTYYFEGGLRKVRPYYFDFQTYCKGRWVGR 173

  Fly   316 KILDIFSREFRAHPAEEYERCIQTGTLTVNFEKV-PIDYRLKHNDLLANIVHRHEVPVTCQPIKI 379
            .:|.:||.|||:.|...||..::.|.|.:|.|.| .::..||.||.|.|.|||||.|||.:||::
  Rat   174 SLLHVFSTEFRSQPLAYYEAAVRAGRLHLNEEPVQDLNIVLKDNDFLRNTVHRHEPPVTAEPIRL 238

  Fly   380 VHMDEDIVVVNKPASIPVHPCGRYRHNTVVFILAKEFNLKNLRTIHRLDRLTSGLLLFGRSPKKA 444
            :..::|:||::||:|||||||||:|||||:|||.||..||.|..:|||||||||:|:|.::...:
  Rat   239 LAENDDVVVIDKPSSIPVHPCGRFRHNTVIFILGKEHQLKELHPLHRLDRLTSGVLMFAKTAAVS 303

  Fly   445 RQMEQQIRNRQVEKEYICRVEGVFPDGIVECKEPIEVVSYKIGVCKVSAKGKDCTTTFQKLSQNG 509
            .::.:|:|:||:||||:|||.|.|||..|.|||||.|||||:|||:|..:||.|.|.||:||.||
  Rat   304 EKIHEQVRDRQLEKEYVCRVAGEFPDKEVICKEPILVVSYKVGVCRVDPQGKPCETVFQRLSYNG 368

  Fly   510 TTSVVLCKPLTGRMHQIRVHLQYLGYPILNDPLYNHEVFGPLKGRSGDIGGKSDEELIRDLINIH 574
            .:|||.|:|||||.||||||||:||:||||||:||...:||.:|:.|.| .|:||||:|||:..|
  Rat   369 RSSVVQCRPLTGRTHQIRVHLQFLGHPILNDPIYNSTAWGPSRGQGGHI-PKTDEELLRDLVAEH 432

  Fly   575 NAENWLG-ID-CDSDISMFKSTKDEADRESLSSEHTSVVHHSDDDGCVNSRETTPPCNEPQQPEN 637
            .|:..|. :| |:.|::                           .|.::|   |.|.:|  ..::
  Rat   433 QAKESLSMLDLCEGDLA---------------------------PGLIDS---TAPSSE--LGKD 465

  Fly   638 SVKLLETTNAVKEYQVAAQKSSSEICPAPLDAVESPLNGGGCNVGKVTVDEHCYECKVHYRDPKS 702
            |::.|.|         ||||....:..|. ...::|......:|.:.| |..|.||:|..:||..
  Rat   466 SLEGLAT---------AAQKIDGMVDEAS-QHPDTPGKAAKADVSQQT-DPLCAECRVLRQDPLP 519

  Fly   703 KDLIMYLHAWKYKGPGWEYETELPNWARNDW 733
            :||:|:|||.:||||.:||.:.:|.||:.||
  Rat   520 QDLVMFLHALRYKGPDFEYVSPIPAWAQADW 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RluA-1	NP_723592.1	Auts2	21..>162	CDD:291981
RluA-1	NP_723592.1	PseudoU_synth_ScRIB2	363..547	CDD:211331	116/183 (63%)
Rpusd2	NP_001129317.1	PseudoU_synth_ScRIB2	221..404	CDD:211331	115/182 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350482
Domainoid	1	1.000	210	1.000	Domainoid score	I2724
eggNOG	1	0.900	-	-		E1_COG0564
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136194
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1773
OMA	1	1.010	-	-		QHG51879
OrthoDB	1	1.010	-	-		D504187at33208
OrthoFinder	1	1.000	-	-		FOG0002443
OrthoInspector	1	1.000	-	-		otm45856
orthoMCL	1	0.900	-	-		OOG6_100211
Panther	1	1.100	-	-	LDO	PTHR21600
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1265
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810