DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RluA-1 and rpusd2

DIOPT Version :9

Sequence 1:	NP_723592.1	Gene:	RluA-1 / 34438	FlyBaseID:	FBgn0051719	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_002940545.1	Gene:	rpusd2 / 100497757	XenbaseID:	XB-GENE-994596	Length:	497	Species:	Xenopus tropicalis

Alignment Length:	512	Identity:	221/512 - (43%)
Similarity:	323/512 - (63%)	Gaps:	45/512 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 AEVPINKKTTSPRDSENLKIKVPEKRKT--DDNDQIKELKKAKLETKALKAKRPGFTDERYQETS 287
            :|..:.:|..:....|....:..:|||.  |.:..:....|.|:..        .|.||.::||.
Frog    23 SEGSLKRKEPNGEPGEGAGKRRHKKRKAAGDGDRHVPPPVKRKVGV--------SFGDEHFRETE 79

  Fly   288 YYMENGLRKVYPYYFTFTTFTKGRWVGEKILDIFSREFRAHPAEEYERCIQTGTLTVNFEKV-PI 351
            .|:|||||||.||||.|.|:.||||||:.:|::|.:||||.|.|.||:..|.|.|.:|.|.| .:
Frog    80 TYLENGLRKVRPYYFDFETYCKGRWVGKSLLEVFGKEFRAEPLEYYEQAAQAGRLRLNEETVRDL 144

  Fly   352 DYRLKHNDLLANIVHRHEVPVTCQPIKIVHMDEDIVVVNKPASIPVHPCGRYRHNTVVFILAKEF 416
            :..||:||.|.|.|||||.|||.:|::|:..::::||::||:|:|||||||:|||||:|||.||:
Frog   145 NVVLKNNDFLRNTVHRHEPPVTAEPLRILAENDEMVVIDKPSSLPVHPCGRFRHNTVIFILGKEY 209

  Fly   417 NLKNLRTIHRLDRLTSGLLLFGRSPKKARQMEQQIRNRQVEKEYICRVEGVFPDGIVECKEPIEV 481
            |||.|.|||||||:|||:|:|.::.:.::::::|:|.||:||||:|||.|.||...|.|:|||.|
Frog   210 NLKGLHTIHRLDRMTSGVLMFAKTLEVSKKIDEQVRQRQLEKEYVCRVCGEFPKEEVTCEEPIFV 274

  Fly   482 VSYKIGVCKVSAKGKDCTTTFQKLSQNGTTSVVLCKPLTGRMHQIRVHLQYLGYPILNDPLYNHE 546
            ||||||||:|..|||.|.|.||:||.||.:|||.|.|.|||.|||||||||||:||:|||:||.|
Frog   275 VSYKIGVCRVDPKGKPCKTVFQRLSYNGKSSVVKCFPYTGRTHQIRVHLQYLGHPIVNDPIYNTE 339

  Fly   547 VFGPLKGRSGDIGGKSDEELIRDLINIHNAENWLGIDCDSDISMFKSTKDEADRESLSSEHTSVV 611
            .:||.:|:.|:| .::||:|:|.|:::|.::..|.|   .|||       |.|.:.: .|:..:.
Frog   340 AWGPNRGKGGEI-NRTDEDLLRALVDVHKSKQSLDI---LDIS-------EEDLQPI-MENAGLK 392

  Fly   612 HHSDDDGCVNSRETTPPCNEPQQPENSVKLLE-TTNAVKEYQVAAQKSSSEICPAPLDAVESPLN 675
            ..::.   |....:.|...:|:......||.| .||:.::      ..||..|....::.:.
Frog   393 SSTEP---VQKEASEPADPQPKDEAQECKLTENVTNSSQD------TDSSAACRITEESSQG--- 445

  Fly   676 GGGCNVGKVTVDEHCYECKVHYRDPKSKDLIMYLHAWKYKGPGWEYETELPNWARND 732
                     :.|..|.||::...||..|||:|||||.:|||..:::.:::|:||:.:
Frog   446 ---------SRDSLCGECRIVRADPSPKDLVMYLHALRYKGAEFDFSSDMPDWAQEN 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RluA-1	NP_723592.1	Auts2	21..>162	CDD:291981
RluA-1	NP_723592.1	PseudoU_synth_ScRIB2	363..547	CDD:211331	115/183 (63%)
rpusd2	XP_002940545.1	PseudoU_synth_ScRIB2	155..337	CDD:211331	113/181 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3011
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136194
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1838
OMA	1	1.010	-	-		QHG51879
OrthoDB	1	1.010	-	-		D504187at33208
OrthoFinder	1	1.000	-	-		FOG0002443
OrthoInspector	1	1.000	-	-		otm48946
Panther	1	1.100	-	-	LDO	PTHR21600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1681
SonicParanoid	1	1.000	-	-		X1265
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110