DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LManII and Man2c1

DIOPT Version :9

Sequence 1:	NP_609408.1	Gene:	LManII / 34437	FlyBaseID:	FBgn0027611	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	XP_006511557.1	Gene:	Man2c1 / 73744	MGIID:	1920994	Length:	1106	Species:	Mus musculus

Alignment Length:	676	Identity:	129/676 - (19%)
Similarity:	218/676 - (32%)	Gaps:	218/676 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QCGYQSCHPTKPNMLNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPE 97
            |.|.:|.|       .:|.:.|.|.|.|               :.:...:.:..|.:.|:|...:
Mouse   269 QHGGESQH-------TIHAMGHCHIDTG---------------VSRCTSKCVFFSQLLAVLIQMQ 311

  Fly    98 KRFIYVESA--------------------------------------FFF--------KWWKEQK 116
            .||:.:|..                                      |.|        :|.|.|.
Mouse   312 LRFLTMEQGLMKLDLRPRAWLWPFKETVRKCARSWSTAVTLMEQNTDFIFACSQAQQLEWVKSQY 376

  Fly   117 PKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLLNDTFGE-CGRPRVGWQID 180
            |.:...::....:|:...:||.|...|......::::.||..|.......||: |..   .|..|
Mouse   377 PGLHARLQEFACRGQFVPVGGTWVEMDGNLPSGEAMVRQFLQGQNFFLQEFGKMCSE---FWLPD 438

  Fly   181 PFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLGEEADLFSGALYNNYQ 245
            .||:|.::..:....|.              :|.:|:  ::.|:...:.......:.|
Mouse   439 TFGYSAQLPQIMQGCGI--------------KRFLTQ--KLSWNLVNSFPHHTFFWEG------- 480

  Fly   246 APDGFCFDILCNDAPIIDGK----HSPDNN---VKERIDTFLDFAKTQSQYYRTNNIIVTMG-GD 302
                            :||.    |.|..:   ::..::..|..........|||:.....| ||
Mouse   481 ----------------LDGSRVLVHFPPGDSYGMQGSVEEVLKTVTNNRDKGRTNHSGFLFGFGD 529

  Fly   303 FTYQAAQVYYKNLDKLIRYGNERQANG-SNINLLYSTPSCYLKSL-HDAG--ITWPTKSDDFFPY 363
            ......|..   ||:|.|..|   .:| ..:.|  |:|.....:| .|:|  .||   ..:.|
Mouse   530 GGGGPTQTM---LDRLKRLSN---TDGLPRVQL--SSPGQLFTALERDSGQLCTW---VGELF-- 581

  Fly   364 ASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQLSALAPKKPEEF---DPHLTFMRETLGIMQH 425
             .:.|   .|.:|:...||:..|:....|...:.||:||..:..:|   ...|..:...|.:.|.
Mouse   582 -LELH---NGTYTTHAQLKKGNRECEQILHDVEVLSSLALARSAQFLYPAAQLQHLWRLLLLNQF 642

  Fly   426 HDAITGTEKEKVALDYAKRMSVAFRACGATTRNALNQL-TVQSKDNVKDTSAKYVFEFKTCALLN 489
            ||.:||:..:.||.|                  |:|.. .::|..|...::|....    ||
Mouse   643 HDVVTGSCIQLVAED------------------AMNYYEDIRSHGNPLLSAAAAAL----CA--- 682

  Fly   490 ITSCPVSEANDRFALTLYNPLAHTVNEYVRIPVPYSNYRIIDNKGVTLESQAVPIPQVLIDIKHR 554
                  .|...: .|.:.|.|.....|.:.:|.|...:.:          ..|.:|.:
Mouse   683 ------GEPGPK-GLLIINTLPWKRTEVLALPKPCGAHSL----------ALVTVPSI------- 723

  Fly   555 NSTAKYEIVFLATNI-PALGYRTYYVEKLDSTEGNTRSKALPKRTSSVTVIGNSHIQLGFDTNGF 618
                .|......|:: |.|..:..:|  :..|:|            ||| :.|..|::..|..|.
Mouse   724 ----GYAPAPTPTSLQPLLPQQPVFV--MQETDG------------SVT-LDNGIIRVRLDPTGC 769

  Fly   619 LSEVTADGLTRLVSQEFLFYEGAVGN 644
            |:     .|..:.|......|||:||
Mouse   770 LT-----SLVLVASGREAIAEGALGN 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManII	NP_609408.1	GH38N_AMII_LAM_like	47..323	CDD:212121	54/330 (16%)
		Alpha-mann_mid	370..445	CDD:214875	21/77 (27%)
		Glyco_hydro_38C	502..957	CDD:285047	30/144 (21%)
Man2c1	XP_006511557.1	AMS1	65..1101	CDD:223460	129/676 (19%)
Man2c1	XP_006511557.1	GH38N_AMII_Man2C1	277..569	CDD:212124	60/356 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940