DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManII and MAN2B1

DIOPT Version :9

Sequence 1:	NP_609408.1	Gene:	LManII / 34437	FlyBaseID:	FBgn0027611	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	XP_005259970.1	Gene:	MAN2B1 / 4125	HGNCID:	6826	Length:	1012	Species:	Homo sapiens

Alignment Length:	1105	Identity:	468/1105 - (42%)
Similarity:	625/1105 - (56%)	Gaps:	156/1105 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CALGCLIHDAD-----LRSIQPK---------------ASQCGYQSCHPTKPNMLNVHLVAHTHD 57
            ||.|||  |:.     .|:::|.               |...||::|...:||||||||:.||||
Human    11 CARGCL--DSAGPWTMSRALRPPLPPLCFFLLLLAAAGARAGGYETCPTVQPNMLNVHLLPHTHD 73

  Fly    58 DVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKWWKEQKPKVQEA 122
            |||||||||||:||.:..||.||||||:|||:.|||.||.:||||||.|||.:||.:|....||.
Human    74 DVGWLKTVDQYFYGIKNDIQHAGVQYILDSVISALLADPTRRFIYVEIAFFSRWWHQQTNATQEV 138

  Fly   123 VKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLLNDTFGECGRPRVGWQIDPFGHSRE 187
            |:.||.||||||..|.|.|||||.|||.:::||.:.|||.|.||||..|||||.|.|||||||||
Human   139 VRDLVRQGRLEFANGGWVMNDEAATHYGAIVDQMTLGLRFLEDTFGNDGRPRVAWHIDPFGHSRE 203

  Fly   188 MASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANL-GEEADLFSGALYNNYQAPDGFC 251
            .||:||||||||.||||||||||..|:.....|.:|..|.:| ...||||:|.|.|.|..|...|
Human   204 QASLFAQMGFDGFFFGRLDYQDKWVRMQKLEMEQVWRASTSLKPPTADLFTGVLPNGYNPPRNLC 268

  Fly   252 FDILCNDAPIIDGKHSPDNNVKERIDTFLDFAKTQSQYYRTNNIIVTMGGDFTYQAAQVYYKNLD 316
            :|:||.|.|:::...||:.|.||.:|.||:.|..|.:|||||:.::|||.||.|:.|.:::||||
Human   269 WDVLCVDQPLVEDPRSPEYNAKELVDYFLNVATAQGRYYRTNHTVMTMGSDFQYENANMWFKNLD 333

  Fly   317 KLIRYGN-ERQANGSNINLLYSTPSCYLKSLHDAGITWPTKSDDFFPYASDPHAYWTGYFTSRPT 380
            ||||..| ::||.||::::|||||:|||..|:.|.:||..|.|||||||..||.:|||||:|||.
Human   334 KLIRLVNAQQQAKGSSVHVLYSTPACYLWELNKANLTWSVKHDDFFPYADGPHQFWTGYFSSRPA 398

  Fly   381 LKRFERDGNHFLQVCKQLSAL-------APKKPEEFDPHLTFMRETLGIMQHHDAITGTEKEKVA 438
            |||:||...:|||||.||.||       .|....:..|    :.|.:.::|||||::||.::.||
Human   399 LKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAP----LNEAMAVLQHHDAVSGTSRQHVA 459

  Fly   439 LDYAKRMSVAFRACGATTRNALNQLTVQSKDNVKDTSAKYVFEFKTCALLNITSCPVSEANDRFA 503
            .|||::::..:..|.....|||.:|.     ..||       .|..|..|||:.||:|:...||.
Human   460 NDYARQLAAGWGPCEVLLSNALARLR-----GFKD-------HFTFCQQLNISICPLSQTAARFQ 512

  Fly   504 LTLYNPLAHTVNEYVRIPVPYSNYRIIDNKGVTLESQAVPIPQVLIDIKHRNSTAKYEIVFLATN 568
            :.:||||...||..||:||....:.:.|..|.|:.|..|..|.       .:|.|....:..:.:
Human   513 VIVYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTVPSDVVIFPS-------SDSQAHPPELLFSAS 570

  Fly   569 IPALGYRTYYVEKLDSTEGNTRS-KALPKRT-SSVTVIGNSHIQLGFDTN-GFLSEV--TADGLT 628
            :||||:.||.|.::...:...|: :.:|:|: |....|.|.||:..||.: |.|.|:  ....|.
Human   571 LPALGFSTYSVAQVPRWKPQARAPQPIPRRSWSPALTIENEHIRATFDPDTGLLMEIMNMNQQLL 635

  Fly   629 RLVSQEFLFYEGAVGNNAEFLNRSSGAYIFRPNENKIHFATDQVEIEVYKGDLVHEVHQKFNDWI 693
            ..|.|.|.:|..::|:|..  :::|||||||||:.|....:...:|.:.|..||.||||.|:.|.
Human   636 LPVRQTFFWYNASIGDNES--DQASGAYIFRPNQQKPLPVSRWAQIHLVKTPLVQEVHQNFSAWC 698

  Fly   694 SQVVRVYNKDSYAEFEWLVGPIPIDDGIGKEVITRFNSDIASDGIFRTDSNGREMIKRKINHRDT 758
            |||||:|....:.|.||.|||||:.|..|||||:||::.:.:.|.|.|||||||:::|:.::|.|
Human   699 SQVVRLYPGQRHLELEWSVGPIPVGDTWGKEVISRFDTPLETKGRFYTDSNGREILERRRDYRPT 763

  Fly   759 WSVKINEAVAGNYYPITTKIDVEDDTARMAILTDRAQGGSSLKDGSLELMVHRRLLKDDAFGVGE 823
            |.:...|.|||||||:.|:|.:.|...::.:||||:||||||:||||||||||||||||..||.|
Human   764 WKLNQTEPVAGNYYPVNTRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDGRGVSE 828

  Fly   824 ALNETEYGDGLIARGKHHLFFGKSTDREGVSLKGIERLTQLEKLLPTWKFFSNMEDYSADEWQTA 888
            .|.|.  |.|...||:|.:..    |....:..|...|.:.|.|.|        :...|.....|
Human   829 PLMEN--GSGAWVRGRHLVLL----DTAQAAAAGHRLLAEQEVLAP--------QVVLAPGGGAA 879

  Fly   889 FTNI-------FSGISLVLPKPVHLLTLEPWHENQLLVRFEHIMENGEDA--SYSQPVQFNVKNV 944
            : |:       |||:...||..||||||..|....:|:|.||....|||:  :.|.||..|::::
Human   880 Y-NLGAPPRTQFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDL 943

  Fly   945 LSAFDVEGIRETTLDGNAWLDESRRLQFAPDPEEAAFNTYATFSQPAESVHLLSAEKPMLGVKYA 1009
            .|.|.:..::||||..|
Human   944 FSTFTITRLQETTLVAN------------------------------------------------ 960

  Fly  1010 DEALPAGQLGAESNRIRRETETRQEKKDEGRSSKSTEGPYNSFKSDSSNQEYIIELSPMEIRTFI 1074
                   ||...::|::..|.|       |.:...|  ||   :.|.:|    |.|.|||||||:
Human   961 -------QLREAASRLKWTTNT-------GPTPHQT--PY---QLDPAN----ITLEPMEIRTFL 1002

Fly 1075 1074
Human 1003 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManII	NP_609408.1	GH38N_AMII_LAM_like	47..323	CDD:212121	166/276 (60%)
		Alpha-mann_mid	370..445	CDD:214875	37/81 (46%)
		Glyco_hydro_38C	502..957	CDD:285047	183/468 (39%)
MAN2B1	XP_005259970.1	PLN02701	63..1001	CDD:178304	451/1048 (43%)
		GH38N_AMII_LAM_like	63..341	CDD:212121	166/277 (60%)
		Alpha-mann_mid	388..466	CDD:214875	37/81 (46%)
		Glyco_hydro_38C	511..1001	CDD:285047	205/584 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	410	1.000	Domainoid score	I684
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37322
Inparanoid	1	1.050	811	1.000	Inparanoid score	I487
Isobase	1	0.950	-	0	Normalized mean entropy	S4230
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm40555
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	LDO	PTHR11607
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	1	1.000	-	-		X1279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820