Protein Alignment LManII and MAN2C1

DIOPT Version :9

• Sequence 1: NP_609408.1
• Gene: LManII / 34437
• FlyBaseID: FBgn0027611
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_001243423.1
• Gene: MAN2C1 / 4123
• HGNCID: 6827
• Length: 1057
• Species: Homo sapiens
• Alignment Length: 1068
• Identity: 196/1068 - (18%)
• Similarity: 347/1068 - (32%)
• Gaps: 312/1068 - (29%)

  Fly    30 KASQCGYQS----------CHPTKPNML--------------------NVHLVAHTHDDVGWLKT 64
            |.:|..:|:          |.|.:|...                    .:|...|.|.|..||
Human   204 KDNQRSFQALYTANQMVNVCDPAQPETFPVAQALASRFFGQHGGESQHTIHATGHCHIDTAWL-- 266

  Fly    65 VDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIYV-ESAFFFKWWKEQKPKVQEAVKMLVE 128
                 :..:..::|....::  :.::.:.|:||  ||:. ..|...:|.|.:.|.:...::....
Human   267 -----WPFKETVRKCARSWV--TALQLMERNPE--FIFACSQAQQLEWVKSRYPGLYSRIQEFAC 322

  Fly   129 QGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLLNDTFGE-CGRPRVGWQIDPFGHSREMASMF 192
            :|:...:||.|...|......::::.||..|.......||: |..   .|..|.||:|.::..:.
Human   323 RGQFVPVGGTWVEMDGNLPSGEAMVRQFLQGQNFFLQEFGKMCSE---FWLPDTFGYSAQLPQIM 384

  Fly   193 AQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLGEEADLFSGALYNNYQAPDGFCFDILCN 257
            ...|.              .|.:|:  ::.|:...:.......:.|
Human   385 HGCGI--------------RRFLTQ--KLSWNLVNSFPHHTFFWEG------------------- 414

  Fly   258 DAPIIDGK----HSPDNN---VKERIDTFLDFAKTQSQYYRTNNIIVTMG-GDFTYQAAQVYYKN 314
                :||.    |.|..:   ::..::..|..........|.|:.....| ||......|..
Human   415 ----LDGSRVLVHFPPGDSYGMQGSVEEVLKTVANNRDKGRANHSAFLFGFGDGGGGPTQTM--- 472

  Fly   315 LDKLIRYGNERQANG------SNINLLYSTPSCYLKSLHDAGITWPTKSDDFFPYASDPHAYWTG 373
            ||:|.|..|   .:|      |:...|:|.    |:|..:...||   ..:.|   .:.|   .|
Human   473 LDRLKRLSN---TDGLPRVQLSSPRQLFSA----LESDSEQLCTW---VGELF---LELH---NG 521

  Fly   374 YFTSRPTLKRFERDGNHFLQVCKQLSALAPKKPEEF---DPHLTFMRETLGIMQHHDAITGTEKE 435
            .:|:...:|:..|:....|...:.||:||..:..:|   ...|..:...|.:.|.||.:||:..:
Human   522 TYTTHAQIKKGNRECERILHDVELLSSLALARSAQFLYPAAQLQHLWRLLLLNQFHDVVTGSCIQ 586

  Fly   436 KVALDYAKRMSVAFRACGATTRNALNQLTVQSKDNVKDTSAKYVFEFKTCALLNITSCPVSEAND 500
            .||.:         ..|        :...::|..|...::|....    ||     ..|..|
Human   587 MVAEE---------AMC--------HYEDIRSHGNTLLSAAAAAL----CA-----GEPGPE--- 622

  Fly   501 RFALTLYNPLAHTVNEYVRIPVPYSNYRIIDNKGVTLESQAVPIPQVLIDIKHRNSTAKYEIVFL 565
              .|.:.|.|.....|.:.:|.|...:.:    |:|        |......:|...:.....:..
Human   623 --GLLIVNTLPWKRIEVMALPKPGGAHSL----GLT--------PSPGDSAQHGLCSCSSPHLTA 673

  Fly   566 ATNIPALGYRTYYVEKLDSTEGNTRSKALPKRTSSVTVIGNSHIQLGFDTNGFLSEVTADGLTRL 630
            |...||...|:      .....::.|:..|.:|.....:.|..|::..|..|.|:     .|..:
Human   674 APAAPAACVRS------ARAPTDSASRPPPTKTDGSVTLDNGIIRVKLDPTGRLT-----SLVLV 727

  Fly   631 VSQEFLFYEGAVGNNAEFLNRSSGAYIFRPNENKIHFATDQVEIEVYKGDLVHEVHQKFNDWI-- 693
            .|......||||||  :|:       :|           |.|.:.....| |.:.|.:....:
Human   728 ASGREAIAEGAVGN--QFV-------LF-----------DDVPLYWDAWD-VMDYHLETRKPVLG 771

  Fly   694 -SQVVRVYNKDSYAEFEWLVGPIPIDDGIGKEVITRFNSDIASDGI-FRTDSNGREMIK------ 750
             :..:.|..:.......|.:..|..:..:.:||:.    |:....: |.|:.:..|..|
Human   772 QAGTLAVGTEGGLRGSAWFLLQISPNSRLSQEVVL----DVGCPYVRFHTEVHWHEAHKFLKVEF 832

  Fly   751 --RKINHRDTWSVKINEAVAGNYYPITTKIDVEDDTARMAILTDRAQGGSSLKDGSLELMVHRRL 813
              |..:.:.|:.::........:|      :...|.||                  .|:..||.:
Human   833 PARVRSSQATYEIQFGHLQRPTHY------NTSWDWAR------------------FEVWAHRWM 873

  Fly   814 -LKDDAFGVGEALNETEYG-------------------DGLIARGKHHLFFGKSTDREGVSLKGI 858
             |.:..||:. .||:.:||                   |.....|:|...:.
Human   874 DLSEHGFGLA-LLNDCKYGASVRGSILSLSLLRAPKAPDATADTGRHEFTYA------------- 924

  Fly   859 ERLTQLEKLLPTWKFFSNMEDYSADEWQTAFTNIFSGISLVLPKPVHLLTLEPWHENQLLVRFEH 923
                    |:|....|.:     |...|.|::..|..::|..|.|....:...:..:...|..|.
Human   925 --------LMPHKGSFQD-----AGVIQAAYSLNFPLLALPAPSPAPATSWSAFSVSSPAVVLET 976

  Fly   924 IMENGEDASYSQPVQFNVKNVLSAFDVEGIRETTLDGNAWLDESRRLQFA--------PDPEEAA 980
            :.:     :.|.|.:.::  ||..::..|...     :.||..|..:|.|        |||  |.
Human   977 VKQ-----AESSPQRRSL--VLRLYEAHGSHV-----DCWLHLSLPVQEAILCDLLERPDP--AG 1027

  Fly   981 FNTY------ATFSQPAESVHLLSAEKP 1002
            ..|.      .||| |.:.:.||...:|
Human  1028 HLTLRDNRLKLTFS-PFQVLSLLLVLQP 1054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManII	NP_609408.1	GH38N_AMII_LAM_like	47..323	CDD:212121	52/305 (17%)
		Alpha-mann_mid	370..445	CDD:214875	19/77 (25%)
		Glyco_hydro_38C	502..957	CDD:285047	83/486 (17%)
MAN2C1	NP_001243423.1	AMS1	68..1026	CDD:223460	187/1037 (18%)
		GH38N_AMII_Man2C1	252..503	CDD:212124	58/313 (19%)
		Alpha-mann_mid	517..596	CDD:286360	21/98 (21%)
		Glyco_hydro_38C	700..1043	CDD:285047	80/438 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030