DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LManII and MAN2A2

DIOPT Version :9

Sequence 1:NP_609408.1 Gene:LManII / 34437 FlyBaseID:FBgn0027611 Length:1080 Species:Drosophila melanogaster
Sequence 2:NP_001307906.1 Gene:MAN2A2 / 4122 HGNCID:6825 Length:1175 Species:Homo sapiens


Alignment Length:1171 Identity:301/1171 - (25%)
Similarity:461/1171 - (39%) Gaps:310/1171 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 LNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKW 111
            |.|.:|.|:|:|.||:||.|:||        ....|:|::|:|..|..||.:||::.|.:||.||
Human   166 LQVFVVPHSHNDPGWIKTFDKYY--------TEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKW 222

  Fly   112 WKEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLLNDTFGECGRPRVG 176
            |.....:.:.||:.||..|:||...|.|.|.|||.:||.::|||...|.:.|....|  ..||.|
Human   223 WDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLG--ATPRSG 285

  Fly   177 WQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLGEEADLFSGAL- 240
            |.:||||:|..|..:..:.....|...|:.|..|.....|.:.|.:|..:.:.....|:|...: 
Human   286 WAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMP 350

  Fly   241 YNNYQAPDGFCFDILCNDAPII----DGKHSP----------------DNNVKERIDTFLDFAKT 285
            :.:|..|.      .|...|.|    |.|..|                :.||.||....||..:.
Human   351 FYSYDVPH------TCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRK 409

  Fly   286 QSQYYRTNNIIVTMGGDFTYQAAQVY---YKNLDKLIRYGNERQANGSNINLLYSTPSCYLKSLH 347
            :||.:|:|.::|.:|.||.|...|.:   :.|..:|..:.|.|.  ..::...:.|.|.|..:|:
Human   410 KSQLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRP--NLHVQAQFGTLSDYFDALY 472

  Fly   348 D-AGIT-------WPTKSDDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQL------ 398
            . .|:.       :|..|.|||.||.....|||||:||||..|..:|.....|:..:.|      
Human   473 KRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAA 537

  Fly   399 ----SALAPKKPEEFDPHLTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRACGATTRNA 459
                |.||.:.|......||..|.|||:.|||||||||.||.|.:||..|:..:.........:|
Human   538 HARRSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHA 602

  Fly   460 LNQLTVQSKD-----------NVKDTSAKY-VFEFKTCALLNITSCPVSEANDRFALTLYNPLAH 512
            .:.|.:..|:           .|.||...: ....:|  ::.:.|.|      || :.|:|||..
Human   603 AHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERT--VIQLDSSP------RF-VVLFNPLEQ 658

  Fly   513 TVNEYVRIPVPYSNYRIIDNKGVTL----------ESQAVP-IPQVLIDIKHRNSTAKYEIVFLA 566
            .....|.:.|.....|::..:|..|          .::||| :.||.:.::              
Human   659 ERFSMVSLLVNSPRVRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVR-------------- 709

  Fly   567 TNIPAL------------GYRTYYVEKLDSTEGN----TRSKALPKRT----SSVTVIGNSHIQL 611
              :|||            |:||..........|.    :|.:|.|.|.    :|...:.|.::|:
Human   710 --LPALGLGVLQLQLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDFALSNRYMQV 772

  Fly   612 GFDTNGFLSEVTADGLTRL--------------VSQEFLFYEGAVGNNAEFLNRSSGAYIFRPN- 661
            .|           .|||.|              |..:.|.|......:      .||||:|.|: 
Human   773 WF-----------SGLTGLLKSIRRVDEEHEQQVDMQVLVYGTRTSKD------KSGAYLFLPDG 820

  Fly   662 ENKIHFATDQVEIEVYKGDLVHEVHQKFNDWISQVVRVYNKDSYAEFEWLVGP-IPIDDGIGKEV 725
            |.|.:...:...:.|.:|....|| ..:.:.|.|.||:||..........:.. :.|.|.:.||:
Human   821 EAKPYVPKEPPVLRVTEGPFFSEV-VAYYEHIHQAVRLYNLPGVEGLSLDISSLVDIRDYVNKEL 884

  Fly   726 ITRFNSDIASDGIFRTDSNGREMIKRKINHRDTWSVKINEAVAGNYYPITTKIDVEDDTARMAIL 790
            ....::||.|.|||.||.||.::..|:      :..|:  .:..|:||:.....::|...|:.:.
Human   885 ALHIHTDIDSQGIFFTDLNGFQVQPRR------YLKKL--PLQANFYPMPVMAYIQDAQKRLTLH 941

  Fly   791 TDRAQGGSSLKDGSLELMVHRRLLKDDAFGVGEALNETEYGDG----LIAR---GKHHLFFGK-- 846
            |.:|.|.||||||.||:::.|||::||..|:|:.|.:.:....    |:.|   |....||.|  
Human   942 TAQALGVSSLKDGQLEVILDRRLMQDDNRGLGQGLKDNKRTCNRFRLLLERRTVGSEPDFFSKLA 1006

  Fly   847 --------STDREGVSLKGIERLTQLEKLLPTWKFFSNMEDYSADEWQTAFTNIFSGI-SLVLPK 902
                    .:.|.|                       |.|  ..|...|::.::.|.: |:.|..
Human  1007 AMFRGLIFHSSRSG-----------------------NRE--VQDSHSTSYPSLLSHLTSMYLNA 1046

  Fly   903 PVHLLTLEPWHENQLLVRFEHIMENGEDASYSQPVQFNVKNVLSAFDVEGIRETTLDGNAWLDES 967
            |...|                            ||                              
Human  1047 PALAL----------------------------PV------------------------------ 1053

  Fly   968 RRLQFAPDPEEAAFNTYATFSQPAESVHLLSAEKPMLGVKYADEALPAGQLGAESNRI--RRETE 1030
            .|:|. |.|...:|:..|: |.|.: .|||:    :..::..::.||:    ||:..|  |:..:
Human  1054 ARMQL-PGPGLRSFHPLAS-SLPCD-FHLLN----LRTLQAEEDTLPS----AETALILHRKGFD 1107

  Fly  1031 TRQEKKDEGRSSKSTEGP-----------------------YNSFKSDSSNQEYIIELSPMEIRT 1072
            ...|.|:.|.:..:::|.                       |......:|...|   |.||||.|
Human  1108 CGLEAKNLGFNCTTSQGKVALGSLFHGLDVVFLQPTSLTLLYPLASPSNSTDVY---LEPMEIAT 1169

  Fly  1073 F 1073
            |
Human  1170 F 1170

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LManIINP_609408.1 GH38N_AMII_LAM_like 47..323 CDD:212121 94/299 (31%)
Alpha-mann_mid 370..445 CDD:214875 37/84 (44%)
Glyco_hydro_38C 502..957 CDD:285047 114/519 (22%)
MAN2A2NP_001307906.1 PLN02701 136..1174 CDD:178304 301/1171 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1959
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3970
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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