DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManII and Man2b2

DIOPT Version :9

Sequence 1:	NP_609408.1	Gene:	LManII / 34437	FlyBaseID:	FBgn0027611	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_001128443.2	Gene:	Man2b2 / 360955	RGDID:	1308840	Length:	1004	Species:	Rattus norvegicus

Alignment Length:	1152	Identity:	306/1152 - (26%)
Similarity:	477/1152 - (41%)	Gaps:	281/1152 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SCHPTKPNMLNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIY 102
            :..|..|  :...:|.|:|.||||:.||.:        ..:|....:..:|||.|:|..::|||.
  Rat    20 AARPASP--IRAFVVPHSHMDVGWVYTVQE--------SMRAYAANVYTTVVEELVRGRQRRFIA 74

  Fly   103 VESAFFFKWW----KEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLL 163
            ||..||..||    .||:   ::.|:.|:::|||||:.|...|:|||.||....|.|.:.|...|
  Rat    75 VEQEFFRLWWDGVASEQQ---KQQVRQLLDEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFL 136

  Fly   164 NDTFGECGRPRVGWQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSAN 228
            .:|||.  ||:..|.:||||.|....::||..||:.....|:||..||.....:..:.:||||.:
  Rat   137 YETFGI--RPQFSWHVDPFGASATTPTLFALAGFNAHLISRIDYDLKDAMQEAQGLQFVWHGSPS 199

  Fly   229 LGEEADLFSGA--LYNNYQAP--------DGFCFD-ILCNDAPIIDGKHSPDNNVKERIDTFLDF 282
            |.|:.::::..  || :|..|        .||.:: :.....|..||.: |:.:....:|....:
  Rat   200 LSEQQEIYTHVMDLY-SYCTPSHIPFSNRSGFYWNGVAVFPEPPPDGVY-PNMSEPVTVDNIHLY 262

  Fly   283 A-------KTQSQYYRTNNIIVTMGGDFTYQAAQVYYKNLDKLIRYGNERQANGSNINLLYSTPS 340
            |       |.::.::||.:::...|.|..:..|.|.:.|:|.|:.|.|.|.|. ..|::.|:|.:
  Rat   263 AEALVANVKQRAAWFRTPHVLWPWGCDKQFFNASVQFDNMDPLLEYINNRSAQ-FGISVQYATLN 326

  Fly   341 CYLKSLHDAGITWPTKS-DDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQLSA--LA 402
            .|.::|||..:||..:. .||.||:|:|...|||:||||.|||...|..:..|...:.:..  :.
  Rat   327 DYFQALHDFNVTWDIRDHHDFLPYSSEPQQAWTGFFTSRSTLKGLARQASALLYAGESMFTRYMW 391

  Fly   403 PKKPEEFDP-----HLTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRACGATTRNALNQ 462
            |......||     .|..:|..:..:||||||||||..||...|.:.:|:..|..
  Rat   392 PHPRGTLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVKNMYMEHLSMGMRGV---------- 446

  Fly   463 LTVQSKDNVKDTSAKYVFEFKTCALLNITSCPVSEANDR---FALTLYNPLAHTVNEYVRIPVPY 524
                               .|..|.:.:...|.|..:.|   ::.::|||||..:...:.:.|.:
  Rat   447 -------------------HKLMASIALDRPPGSGTDTRPVGYSASVYNPLAWKITTIITLTVAF 492

  Fly   525 SNYRIIDNKGVTLESQAVPIPQVLIDIKHRNST---AKYEIVFLATNIPALGYRTYYVEKLDSTE 586
            .:..:.|..|..:.:|.            :|||   :.|:::.| |.||.|.||.|.|.:....:
  Rat   493 PSVSVTDELGRPVSAQI------------QNSTKDPSAYDLLIL-TTIPGLSYRHYKVRRTRGDQ 544

  Fly   587 GNTR------------SKALPKRTSS-----VTVIGNSHIQLGFDTNGFLSEVTADGLTRLV--S 632
            ..||            |:.|..:||.     |.|:.:.:..|.......|..:......|.|  :
  Rat   545 AGTRELVTPRANTLKFSRKLRNQTSQEGKLLVPVMNDCYTLLFDQDTNMLHSIQDRQSNRTVHMT 609

  Fly   633 QEFLFY-------EGAVGNNAEFLNRSSGAYIFRPNENKIHFATDQVEIEVYKGDLVHEVHQKFN 690
            ||||.|       :|.:.:|          |:|..|:. ...:.:.|.:|:..|.|..:|.|.|.
  Rat   610 QEFLEYRANGDVKQGPISDN----------YLFASNDT-AEPSWEAVGMEMVVGTLATDVRQYFY 663

  Fly   691 DWISQVVRVYN--------KDSYA--------EFEWLVGPIPIDDGIGKEVITRFNSDIASDGIF 739
            ..|:....:|:        ..|.|        |.::.|||:.::    :|.|.|.:||:.|..:.
  Rat   664 RNITDQGYIYSIHTRLAHVHPSLAGELLCRRIEQQYQVGPLDLN----REAILRTSSDLNSQQVL 724

  Fly   740 RTDSNGREMIKRKINHRDTWSVKINEAVAGNYYPITTKIDVEDDTARMAILTDRAQGGSSLKDGS 804
            .:|:||.:|.:|...     :.|.| .:..||||:.....:|||.:|:.:|.:|..|.||.::|.
  Rat   725 YSDNNGYQMQRRPYK-----AFKSN-PIPRNYYPMVQSAFIEDDKSRLVLLAERPHGVSSQENGQ 783

  Fly   805 LELMVHRRLLKDDAFGVGE--ALNETEYGDGLIARGKHHLFFG-KST-----DREGVSLKGIERL 861
            :|:|:||||..:..:.:..  .||:|.     :......|..| |||     .|.||:|:  .|.
  Rat   784 VEVMLHRRLWNNLVWDLNYNLTLNDTS-----VVHPVLWLLLGPKSTTTALRPRSGVALQ--HRP 841

  Fly   862 TQLEKLLPTWKFFSNMEDYSADEWQTAFTNIFSGISLVLPKPVHL--LTLEPW-----HENQL-- 917
            ..|.|.|             .||.:||.........:.||..:||  |:|..|     |...|
  Rat   842 VVLLKEL-------------TDEEETAIHRPHHPWPVTLPPSLHLQVLSLPGWQYSRNHAQHLKN 893

  Fly   918 ----------------LVRFEHIMENGEDASYSQPVQFNVKNVLSAF-DVEGIRETTLDGNAWLD 965
                            |:|..|:.|.|||...|:|...::|..|... .|..:.|.:|.| .|
  Rat   894 LQRGHPEKPQVNLQRVLLRLHHLYEAGEDPVLSRPATVDLKIALRGLGSVVAVEERSLTG-TW-- 955

  Fly   966 ESRRLQFAPDPEEAAFNTYATFSQPAESVHLLSAEKPMLGVKYADEALPAGQLGAESNRIRRETE 1030
            :.:.||                                                    |....|:
  Rat   956 DVQTLQ----------------------------------------------------RWHWRTK 968

  Fly  1031 TRQEKKDEGRSSKSTEGPYNSFKSDSSNQEYIIELSPMEIRTFIVYL 1077
            ..|.|   |..:.....|..|          ||.:.|.|||||.:||
  Rat   969 IGQLK---GHPTSPPRSPGGS----------IITVYPKEIRTFFIYL 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManII	NP_609408.1	GH38N_AMII_LAM_like	47..323	CDD:212121	93/297 (31%)
		Alpha-mann_mid	370..445	CDD:214875	30/81 (37%)
		Glyco_hydro_38C	502..957	CDD:285047	134/533 (25%)
Man2b2	NP_001128443.2	PLN02701	27..792	CDD:178304	238/843 (28%)
Man2b2	NP_001128443.2	GH38N_AMII_Epman_like	27..352	CDD:212122	109/340 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020