Protein Alignment LManII and Man2b2

DIOPT Version :10

• Sequence 1: NP_609408.1
• Gene: LManII / 34437
• FlyBaseID: FBgn0027611
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_001128443.2
• Gene: Man2b2 / 360955
• RGDID: 1308840
• Length: 1004
• Species: Rattus norvegicus
• Alignment Length: 1152
• Identity: 306/1152 - (26%)
• Similarity: 477/1152 - (41%)
• Gaps: 281/1152 - (24%)

  Fly    38 SCHPTKPNMLNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIY 102
            :..|..|  :...:|.|:|.||||:.||.:        ..:|....:..:|||.|:|..::|||.
  Rat    20 AARPASP--IRAFVVPHSHMDVGWVYTVQE--------SMRAYAANVYTTVVEELVRGRQRRFIA 74

  Fly   103 VESAFFFKWW----KEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLL 163
            ||..||..||    .||:   ::.|:.|:::|||||:.|...|:|||.||....|.|.:.|...|
  Rat    75 VEQEFFRLWWDGVASEQQ---KQQVRQLLDEGRLEFVLGGQVMHDEAVTHLDDQILQLTEGHGFL 136

  Fly   164 NDTFGECGRPRVGWQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSAN 228
            .:|||.  ||:..|.:||||.|....::||..||:.....|:||..||.....:..:.:||||.:
  Rat   137 YETFGI--RPQFSWHVDPFGASATTPTLFALAGFNAHLISRIDYDLKDAMQEAQGLQFVWHGSPS 199

  Fly   229 LGEEADLFSGA--LYNNYQAP--------DGFCFD-ILCNDAPIIDGKHSPDNNVKERIDTFLDF 282
            |.|:.::::..  || :|..|        .||.:: :.....|..||.: |:.:....:|....:
  Rat   200 LSEQQEIYTHVMDLY-SYCTPSHIPFSNRSGFYWNGVAVFPEPPPDGVY-PNMSEPVTVDNIHLY 262

  Fly   283 A-------KTQSQYYRTNNIIVTMGGDFTYQAAQVYYKNLDKLIRYGNERQANGSNINLLYSTPS 340
            |       |.::.::||.:::...|.|..:..|.|.:.|:|.|:.|.|.|.|. ..|::.|:|.:
  Rat   263 AEALVANVKQRAAWFRTPHVLWPWGCDKQFFNASVQFDNMDPLLEYINNRSAQ-FGISVQYATLN 326

  Fly   341 CYLKSLHDAGITWPTKS-DDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQLSA--LA 402
            .|.::|||..:||..:. .||.||:|:|...|||:||||.|||...|..:..|...:.:..  :.
  Rat   327 DYFQALHDFNVTWDIRDHHDFLPYSSEPQQAWTGFFTSRSTLKGLARQASALLYAGESMFTRYMW 391

  Fly   403 PKKPEEFDP-----HLTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRACGATTRNALNQ 462
            |......||     .|..:|..:..:||||||||||..||...|.:.:|:..|..
  Rat   392 PHPRGTLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVKNMYMEHLSMGMRGV---------- 446

  Fly   463 LTVQSKDNVKDTSAKYVFEFKTCALLNITSCPVSEANDR---FALTLYNPLAHTVNEYVRIPVPY 524
                               .|..|.:.:...|.|..:.|   ::.::|||||..:...:.:.|.:
  Rat   447 -------------------HKLMASIALDRPPGSGTDTRPVGYSASVYNPLAWKITTIITLTVAF 492

  Fly   525 SNYRIIDNKGVTLESQAVPIPQVLIDIKHRNST---AKYEIVFLATNIPALGYRTYYVEKLDSTE 586
            .:..:.|..|..:.:|.            :|||   :.|:::.| |.||.|.||.|.|.:....:
  Rat   493 PSVSVTDELGRPVSAQI------------QNSTKDPSAYDLLIL-TTIPGLSYRHYKVRRTRGDQ 544

  Fly   587 GNTR------------SKALPKRTSS-----VTVIGNSHIQLGFDTNGFLSEVTADGLTRLV--S 632
            ..||            |:.|..:||.     |.|:.:.:..|.......|..:......|.|  :
  Rat   545 AGTRELVTPRANTLKFSRKLRNQTSQEGKLLVPVMNDCYTLLFDQDTNMLHSIQDRQSNRTVHMT 609

  Fly   633 QEFLFY-------EGAVGNNAEFLNRSSGAYIFRPNENKIHFATDQVEIEVYKGDLVHEVHQKFN 690
            ||||.|       :|.:.:|          |:|..|:. ...:.:.|.:|:..|.|..:|.|.|.
  Rat   610 QEFLEYRANGDVKQGPISDN----------YLFASNDT-AEPSWEAVGMEMVVGTLATDVRQYFY 663

  Fly   691 DWISQVVRVYN--------KDSYA--------EFEWLVGPIPIDDGIGKEVITRFNSDIASDGIF 739
            ..|:....:|:        ..|.|        |.::.|||:.::    :|.|.|.:||:.|..:.
  Rat   664 RNITDQGYIYSIHTRLAHVHPSLAGELLCRRIEQQYQVGPLDLN----REAILRTSSDLNSQQVL 724

  Fly   740 RTDSNGREMIKRKINHRDTWSVKINEAVAGNYYPITTKIDVEDDTARMAILTDRAQGGSSLKDGS 804
            .:|:||.:|.:|...     :.|.| .:..||||:.....:|||.:|:.:|.:|..|.||.::|.
  Rat   725 YSDNNGYQMQRRPYK-----AFKSN-PIPRNYYPMVQSAFIEDDKSRLVLLAERPHGVSSQENGQ 783

  Fly   805 LELMVHRRLLKDDAFGVGE--ALNETEYGDGLIARGKHHLFFG-KST-----DREGVSLKGIERL 861
            :|:|:||||..:..:.:..  .||:|.     :......|..| |||     .|.||:|:  .|.
  Rat   784 VEVMLHRRLWNNLVWDLNYNLTLNDTS-----VVHPVLWLLLGPKSTTTALRPRSGVALQ--HRP 841

  Fly   862 TQLEKLLPTWKFFSNMEDYSADEWQTAFTNIFSGISLVLPKPVHL--LTLEPW-----HENQL-- 917
            ..|.|.|             .||.:||.........:.||..:||  |:|..|     |...|
  Rat   842 VVLLKEL-------------TDEEETAIHRPHHPWPVTLPPSLHLQVLSLPGWQYSRNHAQHLKN 893

  Fly   918 ----------------LVRFEHIMENGEDASYSQPVQFNVKNVLSAF-DVEGIRETTLDGNAWLD 965
                            |:|..|:.|.|||...|:|...::|..|... .|..:.|.:|.| .|
  Rat   894 LQRGHPEKPQVNLQRVLLRLHHLYEAGEDPVLSRPATVDLKIALRGLGSVVAVEERSLTG-TW-- 955

  Fly   966 ESRRLQFAPDPEEAAFNTYATFSQPAESVHLLSAEKPMLGVKYADEALPAGQLGAESNRIRRETE 1030
            :.:.||                                                    |....|:
  Rat   956 DVQTLQ----------------------------------------------------RWHWRTK 968

  Fly  1031 TRQEKKDEGRSSKSTEGPYNSFKSDSSNQEYIIELSPMEIRTFIVYL 1077
            ..|.|   |..:.....|..|          ||.:.|.|||||.:||
  Rat   969 IGQLK---GHPTSPPRSPGGS----------IITVYPKEIRTFFIYL 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManII	NP_609408.1	PLN02701	47..823	CDD:178304	240/853 (28%)
		GH38N_AMII_LAM_like	47..323	CDD:212121	93/297 (31%)
Man2b2	NP_001128443.2	PLN02701	27..792	CDD:178304	238/843 (28%)
		GH38N_AMII_Epman_like	27..352	CDD:212122	109/340 (32%)